G12 - OXE receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 73.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 K 193 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 K 193 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 K 193 3x53 G.H5 N 374 G.H5.19
Hydrophobic H8 P 360 8x48 G.H5 Q 381 G.H5.26
Van-der-waals H8 P 360 8x48 G.H5 Q 381 G.H5.26
Hydrophobic C-term K 408 - G.H2 Q 236 G.H2.05
Van-der-waals C-term K 408 - G.H2 Q 236 G.H2.05
Hydrophobic ICL2 H 198 34x51 G.H5 K 367 G.H5.12
Van-der-waals ICL2 H 198 34x51 G.H5 K 367 G.H5.12
Polar ICL2 R 203 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 203 34x56 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 203 34x56 G.hns1 R 55 G.hns1.02
Hydrophobic ICL3 L 284 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 L 284 - G.H5 L 371 G.H5.16
Polar H8 S 359 8x47 G.H5 L 380 G.H5.25
Hydrophobic H8 S 359 8x47 G.H5 L 380 G.H5.25
Van-der-waals H8 S 359 8x47 G.H5 L 380 G.H5.25
Polar TM2 N 127 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM2 N 127 2x39 G.H5 D 377 G.H5.22
Van-der-waals TM2 N 127 2x39 G.H5 D 377 G.H5.22
Hydrophobic C-term R 399 - G.H3 K 284 G.H3.16
Hydrophobic C-term L 407 - G.H3 T 279 G.H3.11
Hydrophobic TM3 V 194 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 V 194 3x54 G.H5 I 378 G.H5.23
Hydrophobic TM3 K 193 3x53 G.H5 I 378 G.H5.23
Hydrophobic H8 N 361 8x49 G.H5 Q 381 G.H5.26
Van-der-waals H8 N 361 8x49 G.H5 Q 381 G.H5.26
Hydrophobic TM6 A 293 6x33 G.H5 L 375 G.H5.20
Polar TM6 Q 287 6x27 G.H5 Q 372 G.H5.17
Polar TM2 N 127 2x39 G.H5 I 378 G.H5.23
Hydrophobic TM2 N 127 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 N 127 2x39 G.H5 I 378 G.H5.23
Hydrophobic ICL2 H 198 34x51 G.S1 V 58 G.S1.02
Ionic C-term K 400 - G.h2s4 D 243 G.h2s4.02
Polar C-term K 400 - G.h2s4 D 243 G.h2s4.02
Van-der-waals C-term K 400 - G.h2s4 D 243 G.h2s4.02
Hydrophobic N-term L 16 - H.hdhe F 173 H.hdhe.01
Polar N-term G 24 - H.hbhc A 138 H.hbhc.02
Hydrophobic N-term G 24 - H.hbhc A 138 H.hbhc.02
Van-der-waals N-term G 24 - H.hbhc A 138 H.hbhc.02
Hydrophobic C-term K 400 - G.H3 L 285 G.H3.17
Hydrophobic N-term P 15 - G.s4h3 R 265 G.s4h3.12
Van-der-waals N-term P 15 - G.s4h3 R 265 G.s4h3.12
Polar H8 S 359 8x47 G.H5 M 379 G.H5.24
Hydrophobic H8 S 359 8x47 G.H5 M 379 G.H5.24
Van-der-waals H8 S 359 8x47 G.H5 M 379 G.H5.24
Hydrophobic ICL2 P 197 34x50 G.H5 I 370 G.H5.15
Polar N-term C 22 - H.hbhc A 138 H.hbhc.02
Hydrophobic N-term C 22 - H.hbhc A 138 H.hbhc.02
Van-der-waals N-term C 22 - H.hbhc A 138 H.hbhc.02
Hydrophobic C-term Y 386 - G.H3 K 284 G.H3.16
Hydrophobic N-term H 20 - H.HA K 103 H.HA.17
Polar H8 N 361 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 N 361 8x49 G.H5 L 380 G.H5.25
Van-der-waals H8 N 361 8x49 G.H5 L 380 G.H5.25
Hydrophobic H8 F 362 8x50 G.H5 L 380 G.H5.25
Polar N-term I 14 - G.s4h3 R 265 G.s4h3.12
Van-der-waals N-term I 14 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM2 L 131 2x43 G.H5 L 380 G.H5.25
Hydrophobic ICL2 H 198 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 H 198 34x51 G.S3 I 221 G.S3.01
Hydrophobic N-term I 13 - G.s4h3 R 265 G.s4h3.12
Van-der-waals N-term I 13 - G.s4h3 R 265 G.s4h3.12
Hydrophobic N-term I 13 - G.s4h3 V 260 G.s4h3.07
Van-der-waals N-term I 13 - G.s4h3 V 260 G.s4h3.07
Hydrophobic C-term A 403 - G.H3 N 283 G.H3.15
Hydrophobic N-term R 23 - H.hbhc A 138 H.hbhc.02
Van-der-waals N-term R 23 - H.hbhc A 138 H.hbhc.02
Polar N-term L 16 - G.s4h3 R 265 G.s4h3.12
Van-der-waals N-term L 16 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM3 V 194 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 V 194 3x54 G.H5 L 375 G.H5.20
Hydrophobic ICL3 R 282 - G.H5 L 371 G.H5.16
Van-der-waals ICL3 R 282 - G.H5 L 371 G.H5.16
Polar ICL2 A 204 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 A 204 34x57 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 A 204 34x57 G.hns1 R 55 G.hns1.02
Hydrophobic N-term I 14 - H.HA L 115 H.HA.29
Hydrophobic TM1 F 117 1x57 G.H5 L 380 G.H5.25
Hydrophobic TM4 S 205 4x38 G.hns1 R 55 G.hns1.02
Van-der-waals TM4 S 205 4x38 G.hns1 R 55 G.hns1.02
Ionic ICL3 R 282 - G.H5 D 368 G.H5.13
Polar ICL3 R 282 - G.H5 D 368 G.H5.13
Hydrophobic ICL3 R 282 - G.H5 D 368 G.H5.13
Van-der-waals ICL3 R 282 - G.H5 D 368 G.H5.13
Hydrophobic N-term L 16 - H.HA V 107 H.HA.21
Hydrophobic C-term I 404 - G.H2 F 239 G.H2.08
Van-der-waals C-term I 404 - G.H2 F 239 G.H2.08
Hydrophobic TM6 R 292 6x32 G.H5 M 379 G.H5.24
Van-der-waals TM6 R 292 6x32 G.H5 M 379 G.H5.24
Hydrophobic ICL2 R 203 34x56 G.H5 I 370 G.H5.15
Van-der-waals ICL2 R 203 34x56 G.H5 I 370 G.H5.15
Hydrophobic C-term E 396 - G.H3 L 285 G.H3.17
Van-der-waals C-term E 396 - G.H3 L 285 G.H3.17
Hydrophobic C-term K 400 - G.H2 F 239 G.H2.08
Ionic TM3 K 193 3x53 G.H5 D 377 G.H5.22
Polar TM3 K 193 3x53 G.H5 D 377 G.H5.22
Van-der-waals TM3 K 193 3x53 G.H5 D 377 G.H5.22
Hydrophobic N-term I 14 - H.HA K 114 H.HA.28
Van-der-waals N-term I 14 - H.HA K 114 H.HA.28
Polar C-term S 414 - G.H2 R 232 G.H2.01
Hydrophobic C-term S 414 - G.H2 R 232 G.H2.01
Van-der-waals C-term S 414 - G.H2 R 232 G.H2.01
Hydrophobic TM3 V 194 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 V 194 3x54 G.H5 L 371 G.H5.16
Polar TM3 R 190 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM3 R 190 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 R 190 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM6 P 290 6x30 G.H5 L 375 G.H5.20
Hydrophobic TM6 A 293 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 A 293 6x33 G.H5 M 379 G.H5.24
Ionic C-term E 383 - G.H3 K 284 G.H3.16
Polar C-term E 383 - G.H3 K 284 G.H3.16
Hydrophobic C-term E 383 - G.H3 K 284 G.H3.16
Van-der-waals C-term E 383 - G.H3 K 284 G.H3.16
Hydrophobic TM6 V 296 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM5 T 278 5x64 G.H5 L 371 G.H5.16
Polar TM2 T 125 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 T 125 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 T 125 2x37 G.H5 D 377 G.H5.22
Hydrophobic C-term L 407 - G.H2 F 239 G.H2.08
Van-der-waals C-term L 407 - G.H2 F 239 G.H2.08
Hydrophobic ICL2 H 198 34x51 G.H5 V 366 G.H5.11
Polar ICL2 R 203 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 203 34x56 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 203 34x56 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 H 198 34x51 G.H5 I 370 G.H5.15
Polar ICL3 R 282 - G.H5 K 367 G.H5.12
Van-der-waals ICL3 R 282 - G.H5 K 367 G.H5.12
Hydrophobic N-term L 16 - H.HA K 114 H.HA.28
Van-der-waals N-term L 16 - H.HA K 114 H.HA.28
Hydrophobic C-term A 403 - G.H2 F 239 G.H2.08
Van-der-waals C-term A 403 - G.H2 F 239 G.H2.08
Hydrophobic C-term L 407 - G.H2 R 235 G.H2.04
Hydrophobic ICL2 V 200 34x53 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 V 200 34x53 G.hns1 R 56 G.hns1.03
Hydrophobic N-term L 16 - H.HA D 110 H.HA.24
Van-der-waals N-term L 16 - H.HA D 110 H.HA.24