Gi2 -
OXE receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.8
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.7
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM3 | V | 194 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 194 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | L | 297 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | ICL2 | H | 198 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL2 | H | 198 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | H | 198 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM4 | S | 205 | 4x38 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | S | 205 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | R | 203 | 34x56 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 203 | 34x56 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL3 | L | 284 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL3 | L | 284 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | L | 284 | - | G.S6 | Y | 321 | G.S6.02 |
Polar | C-term | S | 381 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | S | 381 | - | G.H3 | K | 258 | G.H3.16 |
Ionic | ICL2 | R | 203 | 34x56 | G.s2s3 | D | 194 | G.s2s3.02 |
Polar | ICL2 | R | 203 | 34x56 | G.s2s3 | D | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 203 | 34x56 | G.s2s3 | D | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 203 | 34x56 | G.s2s3 | D | 194 | G.s2s3.02 |
Polar | TM2 | N | 127 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM2 | N | 127 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Polar | H8 | S | 359 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | H8 | S | 359 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | S | 359 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | C-term | W | 392 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Van-der-waals | C-term | W | 392 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Polar | TM6 | A | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | A | 293 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | I | 279 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | P | 290 | 6x30 | G.H5 | F | 355 | G.H5.26 |
Polar | TM6 | Q | 287 | 6x27 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM6 | Q | 287 | 6x27 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM6 | Q | 287 | 6x27 | G.S6 | Y | 321 | G.S6.02 |
Ionic | C-term | E | 383 | - | G.H3 | K | 258 | G.H3.16 |
Polar | C-term | E | 383 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | E | 383 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | E | 383 | - | G.H3 | K | 258 | G.H3.16 |
Aromatic | C-term | Y | 386 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | Y | 386 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | Y | 386 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | Y | 394 | - | G.HN | I | 19 | G.HN.43 |
Van-der-waals | C-term | Y | 394 | - | G.HN | I | 19 | G.HN.43 |
Hydrophobic | TM3 | K | 193 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | K | 193 | 3x53 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | C-term | S | 384 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | S | 384 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | ICL2 | P | 197 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | P | 197 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | TM4 | V | 206 | 4x39 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL2 | H | 198 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM3 | R | 190 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 190 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | H | 198 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL2 | H | 198 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Ionic | ICL1 | R | 122 | 12x49 | G.HN | D | 20 | G.HN.44 |
Polar | ICL1 | R | 122 | 12x49 | G.HN | D | 20 | G.HN.44 |
Ionic | ICL3 | R | 282 | - | G.H5 | D | 342 | G.H5.13 |
Polar | ICL3 | R | 282 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL3 | R | 282 | - | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL3 | R | 282 | - | G.H5 | D | 342 | G.H5.13 |
Polar | TM3 | R | 190 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 190 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 190 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM6 | G | 289 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | G | 289 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | H8 | P | 360 | 8x48 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | H8 | P | 360 | 8x48 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | C-term | R | 393 | - | G.HN | L | 23 | G.HN.47 |
Van-der-waals | C-term | R | 393 | - | G.HN | L | 23 | G.HN.47 |
Aromatic | ICL2 | H | 198 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | ICL2 | H | 198 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | H | 198 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Ionic | ICL3 | R | 282 | - | G.H5 | D | 338 | G.H5.09 |
Polar | ICL3 | R | 282 | - | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | ICL3 | R | 282 | - | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM6 | A | 293 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL3 | R | 282 | - | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL3 | R | 282 | - | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL3 | L | 284 | - | G.H5 | I | 345 | G.H5.16 |
Polar | TM2 | N | 127 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Polar | TM6 | Q | 287 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | Q | 287 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 287 | 6x27 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM3 | V | 194 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | V | 194 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | H | 198 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | H | 198 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM6 | P | 290 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | R | 203 | 34x56 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | R | 203 | 34x56 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM6 | R | 292 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 292 | 6x32 | G.H5 | F | 355 | G.H5.26 |
Polar | TM3 | K | 193 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | K | 193 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | K | 193 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM4 | G | 207 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM6 | V | 296 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | T | 278 | 5x64 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL3 | R | 282 | - | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL3 | R | 282 | - | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL2 | P | 197 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Polar | TM4 | V | 206 | 4x39 | G.HN | E | 28 | G.HN.52 |
Ionic | TM3 | K | 193 | 3x53 | G.H5 | D | 351 | G.H5.22 |
Polar | TM3 | K | 193 | 3x53 | G.H5 | D | 351 | G.H5.22 |