Gt2 -
OXE receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | S | 398 | - | G.HN | L | 23 | G.HN.47 |
Van-der-waals | C-term | S | 398 | - | G.HN | L | 23 | G.HN.47 |
Polar | ICL2 | R | 203 | 34x56 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 203 | 34x56 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 203 | 34x56 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | C-term | Y | 394 | - | G.HN | A | 27 | G.HN.51 |
Hydrophobic | C-term | Y | 394 | - | G.HN | A | 27 | G.HN.51 |
Van-der-waals | C-term | Y | 394 | - | G.HN | A | 27 | G.HN.51 |
Hydrophobic | H8 | P | 360 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | H8 | P | 360 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Polar | C-term | R | 390 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | C-term | R | 390 | - | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | C-term | R | 390 | - | G.hns1 | E | 30 | G.hns1.01 |
Aromatic | ICL2 | H | 198 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Hydrophobic | ICL2 | H | 198 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL2 | H | 198 | 34x51 | G.H5 | F | 336 | G.H5.08 |
Ionic | N-term | E | 19 | - | G.H2 | K | 209 | G.H2.05 |
Polar | ICL2 | H | 198 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | H | 198 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | H | 198 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Polar | TM2 | N | 127 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM2 | N | 127 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | R | 282 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL3 | R | 282 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | T | 278 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | I | 279 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Polar | C-term | Q | 387 | - | G.h3s5 | A | 261 | G.h3s5.02 |
Hydrophobic | C-term | Q | 387 | - | G.h3s5 | A | 261 | G.h3s5.02 |
Van-der-waals | C-term | Q | 387 | - | G.h3s5 | A | 261 | G.h3s5.02 |
Hydrophobic | ICL3 | L | 284 | - | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | ICL3 | L | 284 | - | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | P | 290 | 6x30 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | N-term | L | 16 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | ICL2 | R | 203 | 34x56 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | R | 203 | 34x56 | G.S3 | L | 194 | G.S3.01 |
Polar | TM6 | R | 292 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | R | 292 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | R | 292 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Ionic | C-term | R | 393 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | C-term | R | 393 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | TM6 | P | 290 | 6x30 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | P | 290 | 6x30 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM4 | V | 206 | 4x39 | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | TM4 | V | 206 | 4x39 | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | TM6 | G | 289 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | G | 289 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Polar | C-term | Q | 387 | - | G.h3s5 | T | 262 | G.h3s5.03 |
Van-der-waals | C-term | Q | 387 | - | G.h3s5 | T | 262 | G.h3s5.03 |
Polar | C-term | R | 393 | - | G.h2s4 | G | 217 | G.h2s4.03 |
Hydrophobic | C-term | R | 393 | - | G.h2s4 | G | 217 | G.h2s4.03 |
Van-der-waals | C-term | R | 393 | - | G.h2s4 | G | 217 | G.h2s4.03 |
Polar | TM3 | R | 190 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 190 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 190 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | L | 284 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | H | 198 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | H | 198 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | C-term | Q | 387 | - | G.h3s5 | A | 260 | G.h3s5.01 |
Polar | C-term | R | 390 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | R | 390 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | C-term | R | 390 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | H | 198 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM6 | V | 296 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 296 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | Y | 394 | - | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM2 | N | 127 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM3 | V | 194 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM3 | V | 194 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | Q | 387 | - | G.H3 | F | 258 | G.H3.17 |
Hydrophobic | N-term | L | 16 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | TM3 | R | 190 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 190 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | Y | 394 | - | G.HN | D | 26 | G.HN.50 |
Hydrophobic | C-term | Y | 394 | - | G.HN | D | 26 | G.HN.50 |
Hydrophobic | TM3 | V | 194 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | V | 194 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Ionic | ICL3 | R | 282 | - | G.H5 | D | 337 | G.H5.09 |
Polar | ICL3 | R | 282 | - | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | R | 282 | - | G.H5 | D | 337 | G.H5.09 |
Ionic | ICL1 | R | 122 | 12x49 | G.HN | E | 20 | G.HN.44 |
Polar | ICL1 | R | 122 | 12x49 | G.HN | E | 20 | G.HN.44 |
Van-der-waals | ICL1 | R | 122 | 12x49 | G.HN | E | 20 | G.HN.44 |
Polar | H8 | S | 359 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | H8 | S | 359 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | H8 | S | 359 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | TM6 | A | 293 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | A | 293 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | A | 293 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | N-term | V | 11 | - | G.H3 | H | 248 | G.H3.07 |
Ionic | C-term | R | 393 | - | G.hns1 | E | 30 | G.hns1.01 |
Polar | C-term | R | 393 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | C-term | R | 393 | - | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | C-term | R | 393 | - | G.hns1 | E | 30 | G.hns1.01 |
Polar | C-term | Y | 394 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | C-term | Y | 394 | - | G.hns1 | E | 30 | G.hns1.01 |
Van-der-waals | C-term | Y | 394 | - | G.hns1 | E | 30 | G.hns1.01 |
Hydrophobic | N-term | L | 16 | - | G.H2 | I | 212 | G.H2.08 |
Polar | TM6 | Q | 287 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | Q | 287 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 287 | 6x27 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | Q | 287 | 6x27 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | Q | 287 | 6x27 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | Q | 287 | 6x27 | G.H5 | K | 345 | G.H5.17 |
Ionic | C-term | K | 400 | - | G.h2s4 | E | 216 | G.h2s4.02 |
Hydrophobic | ICL2 | R | 203 | 34x56 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 203 | 34x56 | G.hns1 | K | 32 | G.hns1.03 |
Polar | C-term | R | 390 | - | G.S1 | T | 33 | G.S1.01 |
Van-der-waals | C-term | R | 390 | - | G.S1 | T | 33 | G.S1.01 |
Polar | C-term | Q | 391 | - | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | C-term | Q | 391 | - | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | P | 197 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | P | 197 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | P | 197 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | P | 197 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | A | 293 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | L | 297 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | K | 193 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | K | 193 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | K | 193 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | R | 282 | - | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL3 | R | 282 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL3 | L | 284 | - | G.H5 | I | 344 | G.H5.16 |
Ionic | ICL3 | R | 282 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | R | 282 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | R | 282 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | R | 282 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | K | 193 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | K | 193 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL3 | L | 284 | - | G.h4s6 | E | 318 | G.h4s6.12 |