Gz -
OT receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 11.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | P | 144 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 144 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM3 | I | 141 | 3x54 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL3 | V | 260 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | V | 260 | - | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM3 | I | 141 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM6 | I | 266 | 6x26 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | T | 273 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Ionic | ICL3 | A | 256 | - | G.HG | K | 272 | G.HG.01 |
Polar | ICL3 | A | 256 | - | G.HG | K | 272 | G.HG.01 |
Van-der-waals | ICL3 | A | 256 | - | G.HG | K | 272 | G.HG.01 |
Polar | ICL2 | S | 147 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | S | 147 | - | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | S | 147 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | TM3 | A | 140 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM4 | R | 149 | 4x38 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | TM4 | R | 149 | 4x38 | G.hns1 | R | 32 | G.hns1.03 |
Ionic | TM5 | K | 234 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | K | 234 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | K | 234 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | K | 234 | 5x72 | G.H5 | D | 342 | G.H5.13 |
Polar | TM3 | A | 140 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | A | 140 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | L | 145 | - | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 145 | - | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM3 | I | 141 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | I | 141 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL3 | S | 261 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | TM6 | L | 265 | 6x25 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | TM6 | A | 269 | 6x29 | G.H5 | L | 349 | G.H5.20 |
Polar | TM5 | N | 230 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | N | 230 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL2 | L | 145 | - | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | L | 145 | - | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | TM6 | A | 269 | 6x29 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | L | 265 | 6x25 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | L | 265 | 6x25 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL3 | S | 261 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL3 | S | 261 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | S | 261 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | TM6 | A | 269 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM7 | F | 332 | 7x56 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | ICL3 | P | 244 | - | G.H4 | V | 302 | G.H4.08 |
Van-der-waals | ICL3 | V | 260 | - | G.S6 | I | 320 | G.S6.01 |
Polar | C-term | S | 366 | - | G.H3 | N | 258 | G.H3.16 |
Polar | TM3 | R | 137 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 137 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 137 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Polar | C-term | N | 367 | - | G.H3 | N | 258 | G.H3.16 |
Van-der-waals | C-term | N | 367 | - | G.H3 | N | 258 | G.H3.16 |
Ionic | TM5 | K | 234 | 5x72 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM5 | K | 234 | 5x72 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM5 | K | 234 | 5x72 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL3 | V | 260 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | V | 260 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL3 | A | 258 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | ICL3 | A | 258 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | C-term | L | 373 | - | G.H3 | R | 249 | G.H3.07 |
Van-der-waals | C-term | L | 373 | - | G.H3 | R | 249 | G.H3.07 |
Polar | TM6 | R | 272 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | R | 272 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | R | 272 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Polar | C-term | H | 375 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | ICL3 | S | 262 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | S | 262 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM5 | K | 234 | 5x72 | G.H5 | Q | 346 | G.H5.17 |
Polar | ICL3 | R | 259 | - | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | ICL3 | R | 259 | - | G.S6 | S | 322 | G.S6.03 |
Hydrophobic | TM5 | I | 227 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM5 | I | 227 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | L | 145 | - | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | L | 145 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM6 | L | 265 | 6x25 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | TM6 | L | 265 | 6x25 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | TM2 | L | 74 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | P | 144 | - | G.H5 | I | 345 | G.H5.16 |
Polar | ICL3 | A | 258 | - | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | ICL3 | A | 258 | - | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | TM6 | M | 276 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | M | 276 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL3 | P | 244 | - | G.S6 | F | 324 | G.S6.05 |
Van-der-waals | ICL3 | P | 244 | - | G.S6 | F | 324 | G.S6.05 |
Van-der-waals | ICL3 | A | 258 | - | G.S6 | S | 322 | G.S6.03 |
Polar | TM6 | R | 272 | 6x32 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM6 | R | 272 | 6x32 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM6 | R | 272 | 6x32 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL3 | S | 262 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Hydrophobic | ICL3 | P | 244 | - | G.H4 | E | 298 | G.H4.04 |
Hydrophobic | TM2 | L | 74 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | L | 74 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | S | 72 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | S | 72 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM6 | R | 272 | 6x32 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | R | 272 | 6x32 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | P | 144 | - | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM6 | L | 265 | 6x25 | G.h4s6 | T | 317 | G.h4s6.10 |
Hydrophobic | ICL3 | P | 244 | - | G.H4 | A | 301 | G.H4.07 |
Hydrophobic | ICL3 | P | 244 | - | G.H4 | Y | 297 | G.H4.03 |
Van-der-waals | ICL3 | P | 244 | - | G.H4 | Y | 297 | G.H4.03 |