GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | M | 62 | 2x43 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM2 | M | 62 | 2x43 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL2 | K | 132 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | ICL2 | K | 132 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | ICL2 | K | 132 | 34x54 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM6 | R | 232 | 6x31 | G.H5 | L | 388 | G.H5.20 |
Polar | ICL3 | H | 227 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL3 | H | 227 | - | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | ICL3 | H | 227 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | C-term | F | 326 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Van-der-waals | C-term | F | 326 | - | G.h2s4 | N | 239 | G.h2s4.02 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL3 | H | 227 | - | G.S6 | C | 359 | G.S6.01 |
Van-der-waals | ICL3 | H | 227 | - | G.S6 | C | 359 | G.S6.01 |
Hydrophobic | TM2 | S | 58 | 2x39 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM2 | V | 59 | 2x40 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM2 | V | 59 | 2x40 | G.H5 | L | 394 | G.H5.26 |
Ionic | C-term | D | 316 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Polar | C-term | D | 316 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | C-term | D | 316 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Van-der-waals | C-term | D | 316 | - | G.h4s6 | R | 356 | G.h4s6.12 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | L | 129 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Polar | ICL2 | L | 129 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | L | 129 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | TM3 | V | 125 | 3x54 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | S | 56 | 2x37 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM2 | S | 56 | 2x37 | G.H5 | L | 394 | G.H5.26 |
Ionic | TM6 | R | 232 | 6x31 | G.H5 | D | 381 | G.H5.13 |
Polar | TM6 | R | 232 | 6x31 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM6 | R | 232 | 6x31 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | F | 326 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Van-der-waals | C-term | F | 326 | - | G.h2s4 | D | 240 | G.h2s4.03 |
Hydrophobic | ICL2 | S | 130 | 34x52 | G.S3 | V | 217 | G.S3.01 |
Polar | C-term | R | 322 | - | G.H3 | W | 281 | G.H3.17 |
Polar | TM3 | G | 124 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | G | 124 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Polar | H8 | S | 297 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | H8 | S | 297 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | S | 297 | 8x47 | G.H5 | E | 392 | G.H5.24 |
Polar | TM3 | R | 121 | 3x50 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM3 | R | 121 | 3x50 | G.H5 | L | 394 | G.H5.26 |
Polar | ICL2 | R | 135 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Aromatic | ICL2 | R | 135 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | R | 135 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | R | 135 | 34x57 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM4 | R | 136 | 4x38 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM4 | R | 138 | 4x40 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM4 | R | 138 | 4x40 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | R | 138 | 4x40 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM5 | L | 220 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | TM7 | Y | 293 | 7x53 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | TM7 | Y | 293 | 7x53 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | P | 128 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | TM4 | R | 136 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM4 | R | 136 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Van-der-waals | TM4 | R | 136 | 4x38 | G.HN | Q | 35 | G.HN.52 |
Hydrophobic | TM6 | Q | 231 | 6x30 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Hydrophobic | TM6 | A | 235 | 6x34 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | H8 | E | 299 | 8x49 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | H8 | E | 299 | 8x49 | G.H5 | L | 393 | G.H5.25 |
Polar | TM3 | R | 121 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 121 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 121 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Polar | TM3 | G | 124 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | G | 124 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL1 | M | 52 | - | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | ICL1 | M | 52 | - | G.H5 | L | 394 | G.H5.26 |
Polar | H8 | S | 297 | 8x47 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | H8 | S | 297 | 8x47 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | H8 | S | 297 | 8x47 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | ICL3 | E | 225 | - | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | ICL3 | E | 225 | - | G.H5 | D | 381 | G.H5.13 |
Polar | TM3 | V | 125 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | V | 125 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | V | 125 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Polar | TM6 | Q | 231 | 6x30 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | Q | 231 | 6x30 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | TM6 | Q | 231 | 6x30 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL2 | R | 133 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Ionic | ICL3 | E | 225 | - | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | P | 128 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | C-term | F | 359 | - | G.H2 | R | 231 | G.H2.04 |
Van-der-waals | C-term | F | 359 | - | G.H2 | R | 231 | G.H2.04 |
Polar | TM4 | R | 136 | 4x38 | G.HN | K | 34 | G.HN.51 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | L | 129 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Hydrophobic | C-term | L | 318 | - | G.H3 | W | 281 | G.H3.17 |
Ionic | ICL3 | E | 225 | - | G.H5 | R | 380 | G.H5.12 |
Polar | C-term | R | 322 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Van-der-waals | C-term | R | 322 | - | G.h3s5 | T | 284 | G.h3s5.02 |
Hydrophobic | C-term | R | 321 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | TM6 | Q | 231 | 6x30 | G.H5 | R | 389 | G.H5.21 |
Polar | C-term | F | 359 | - | G.H3 | N | 279 | G.H3.15 |
Van-der-waals | C-term | F | 359 | - | G.H3 | N | 279 | G.H3.15 |
Ionic | TM6 | R | 234 | 6x33 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | TM6 | R | 234 | 6x33 | G.H5 | E | 392 | G.H5.24 |
Polar | TM6 | R | 232 | 6x31 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL2 | K | 132 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | K | 132 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | K | 132 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | C-term | R | 322 | - | G.h3s5 | I | 285 | G.h3s5.03 |
Van-der-waals | C-term | R | 322 | - | G.h3s5 | I | 285 | G.h3s5.03 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Polar | ICL2 | K | 132 | 34x54 | G.S1 | T | 40 | G.S1.01 |
Van-der-waals | ICL2 | K | 132 | 34x54 | G.S1 | T | 40 | G.S1.01 |
Hydrophobic | H8 | R | 298 | 8x48 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | H8 | R | 298 | 8x48 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM3 | V | 125 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | C-term | L | 325 | - | G.H3 | W | 281 | G.H3.17 |
Van-der-waals | C-term | L | 325 | - | G.H3 | W | 281 | G.H3.17 |
Ionic | C-term | D | 316 | - | G.h3s5 | R | 283 | G.h3s5.01 |
Polar | TM3 | E | 120 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | E | 120 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | E | 120 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | L | 318 | - | G.H3 | R | 280 | G.H3.16 |