GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 18.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | P | 128 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | R | 321 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Van-der-waals | C-term | R | 321 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Polar | ICL2 | K | 132 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | ICL2 | K | 132 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.S1 | I | 34 | G.S1.02 |
Van-der-waals | ICL2 | L | 129 | 34x51 | G.S1 | I | 34 | G.S1.02 |
Hydrophobic | H8 | S | 297 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL2 | R | 133 | 34x55 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | R | 133 | 34x55 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | R | 133 | 34x55 | G.hns1 | R | 31 | G.hns1.02 |
Polar | C-term | R | 349 | - | H.HA | Y | 75 | H.HA.13 |
Hydrophobic | C-term | R | 349 | - | H.HA | Y | 75 | H.HA.13 |
Van-der-waals | C-term | R | 349 | - | H.HA | Y | 75 | H.HA.13 |
Polar | TM6 | Q | 231 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | Q | 231 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | Q | 231 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | A | 239 | 6x38 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | S | 56 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | S | 56 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | L | 325 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | C-term | L | 325 | - | G.H3 | N | 257 | G.H3.15 |
Ionic | C-term | R | 354 | - | G.S3 | D | 201 | G.S3.07 |
Polar | TM2 | S | 58 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | S | 58 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Polar | C-term | S | 357 | - | G.S2 | I | 185 | G.S2.01 |
Van-der-waals | C-term | S | 357 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | TM6 | Q | 231 | 6x30 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | C-term | F | 359 | - | G.S2 | I | 185 | G.S2.01 |
Polar | TM6 | A | 235 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 235 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | A | 235 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | E | 356 | - | G.S2 | I | 185 | G.S2.01 |
Van-der-waals | C-term | E | 356 | - | G.S2 | I | 185 | G.S2.01 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | L | 129 | 34x51 | G.hns1 | R | 31 | G.hns1.02 |
Polar | TM2 | S | 58 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM2 | S | 58 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | S | 58 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM4 | R | 136 | 4x38 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | TM4 | R | 136 | 4x38 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | H8 | S | 297 | 8x47 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | H8 | S | 297 | 8x47 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | C-term | P | 350 | - | H.HA | L | 72 | H.HA.10 |
Hydrophobic | TM3 | E | 120 | 3x49 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | E | 120 | 3x49 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 121 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 121 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL3 | E | 225 | - | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | ICL3 | E | 225 | - | G.H5 | D | 342 | G.H5.13 |
Ionic | C-term | R | 354 | - | G.hfs2 | D | 180 | G.hfs2.03 |
Polar | C-term | R | 354 | - | G.hfs2 | D | 180 | G.hfs2.03 |
Hydrophobic | C-term | R | 354 | - | G.hfs2 | D | 180 | G.hfs2.03 |
Van-der-waals | C-term | R | 354 | - | G.hfs2 | D | 180 | G.hfs2.03 |
Polar | ICL2 | R | 133 | 34x55 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | ICL2 | R | 133 | 34x55 | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | ICL2 | R | 133 | 34x55 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | C-term | L | 352 | - | H.HA | L | 72 | H.HA.10 |
Hydrophobic | C-term | M | 344 | - | H.HA | R | 86 | H.HA.24 |
Van-der-waals | C-term | M | 344 | - | H.HA | R | 86 | H.HA.24 |
Van-der-waals | TM6 | Q | 231 | 6x30 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | C-term | V | 313 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | C-term | V | 313 | - | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | TM3 | G | 124 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | G | 124 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | C-term | L | 352 | - | H.HA | E | 68 | H.HA.06 |
Polar | TM3 | R | 121 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 121 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 121 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Polar | C-term | R | 354 | - | G.hfs2 | T | 182 | G.hfs2.05 |
Van-der-waals | C-term | R | 354 | - | G.hfs2 | T | 182 | G.hfs2.05 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | L | 129 | 34x51 | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL1 | R | 55 | - | G.H5 | Y | 351 | G.H5.22 |
Polar | C-term | E | 356 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Hydrophobic | C-term | E | 356 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Van-der-waals | C-term | E | 356 | - | G.hfs2 | T | 183 | G.hfs2.06 |
Polar | ICL2 | R | 135 | 34x57 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | R | 135 | 34x57 | G.H5 | N | 348 | G.H5.19 |
Polar | H8 | R | 298 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | H8 | R | 298 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | H8 | R | 298 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | C-term | R | 354 | - | G.H1 | S | 47 | G.H1.02 |
Polar | C-term | E | 356 | - | G.hfs2 | G | 184 | G.hfs2.07 |
Hydrophobic | C-term | E | 356 | - | G.hfs2 | G | 184 | G.hfs2.07 |
Hydrophobic | C-term | P | 350 | - | H.HA | Y | 75 | H.HA.13 |
Hydrophobic | C-term | F | 359 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | ICL2 | P | 128 | 34x50 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | C-term | F | 326 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | TM5 | L | 220 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | V | 125 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Polar | TM6 | G | 228 | 6x27 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | G | 228 | 6x27 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | G | 228 | 6x27 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | ICL3 | H | 227 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | C-term | E | 356 | - | G.S2 | V | 186 | G.S2.02 |
Hydrophobic | ICL3 | H | 227 | - | G.H5 | A | 339 | G.H5.10 |
Ionic | ICL3 | E | 225 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Polar | ICL3 | E | 225 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Van-der-waals | ICL3 | E | 225 | - | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | C-term | L | 325 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | L | 325 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | L | 318 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Van-der-waals | C-term | L | 318 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Hydrophobic | C-term | S | 357 | - | G.S2 | E | 187 | G.S2.03 |
Van-der-waals | C-term | S | 357 | - | G.S2 | E | 187 | G.S2.03 |
Hydrophobic | C-term | R | 354 | - | G.S2 | V | 186 | G.S2.02 |
Hydrophobic | C-term | P | 350 | - | H.HA | P | 71 | H.HA.09 |
Ionic | H8 | R | 311 | 8x61 | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | H8 | R | 311 | 8x61 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | H8 | R | 311 | 8x61 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | H8 | R | 311 | 8x61 | G.h4s6 | E | 316 | G.h4s6.09 |
Hydrophobic | TM2 | P | 57 | 2x38 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | F | 326 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | TM3 | V | 125 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 125 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | S | 130 | 34x52 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | S | 130 | 34x52 | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL3 | H | 227 | - | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | ICL3 | H | 227 | - | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | C-term | L | 352 | - | H.HA | Y | 69 | H.HA.07 |
Van-der-waals | C-term | L | 352 | - | H.HA | Y | 69 | H.HA.07 |
Hydrophobic | ICL2 | L | 129 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 129 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM6 | L | 238 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 235 | 6x34 | G.H5 | C | 355 | G.H5.26 |
Polar | TM3 | R | 121 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM3 | R | 121 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM3 | R | 121 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM5 | T | 216 | 5x61 | G.H5 | L | 354 | G.H5.25 |