GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 86.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 13.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL3 | A | 231 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | ICL3 | A | 231 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | TM2 | K | 68 | 2x38 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM2 | K | 68 | 2x38 | G.H5 | N | 370 | G.H5.19 |
Polar | ICL2 | R | 142 | 34x54 | G.S1 | L | 48 | G.S1.01 |
Van-der-waals | ICL2 | R | 142 | 34x54 | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | ICL2 | R | 142 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | R | 142 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL2 | A | 141 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | A | 141 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Polar | TM3 | F | 134 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM2 | I | 70 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Aromatic | TM6 | F | 232 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | F | 232 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | F | 232 | 6x25 | G.H5 | H | 368 | G.H5.17 |
Ionic | TM6 | E | 237 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Polar | TM6 | E | 237 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | E | 237 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | E | 237 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM7 | A | 309 | 7x57 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | A | 309 | 7x57 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM1 | I | 63 | 1x61 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | P | 138 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | F | 134 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | F | 134 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Polar | TM4 | K | 145 | 4x38 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM4 | K | 145 | 4x38 | G.HN | T | 43 | G.HN.52 |
Van-der-waals | TM4 | K | 145 | 4x38 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM6 | A | 241 | 6x34 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | A | 241 | 6x34 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL2 | R | 142 | 34x54 | G.h2s4 | T | 241 | G.h2s4.05 |
Hydrophobic | ICL2 | R | 142 | 34x54 | G.h2s4 | T | 241 | G.h2s4.05 |
Van-der-waals | ICL2 | R | 142 | 34x54 | G.h2s4 | T | 241 | G.h2s4.05 |
Hydrophobic | ICL3 | M | 230 | - | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | ICL3 | M | 230 | - | G.H5 | R | 360 | G.H5.09 |
Polar | TM7 | E | 311 | 7x59 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM7 | E | 311 | 7x59 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | E | 311 | 7x59 | G.H5 | L | 376 | G.H5.25 |
Aromatic | ICL2 | F | 139 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Polar | TM6 | Q | 233 | 6x26 | G.h4s6 | R | 334 | G.h4s6.08 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM2 | A | 69 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | V | 245 | 6x38 | G.H5 | M | 375 | G.H5.24 |
Polar | TM3 | R | 131 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 131 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | F | 139 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | TM3 | L | 135 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | L | 135 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM6 | F | 232 | 6x25 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM6 | F | 232 | 6x25 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM2 | M | 73 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | M | 73 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM7 | S | 310 | 7x58 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM7 | S | 310 | 7x58 | G.H5 | Q | 377 | G.H5.26 |
Ionic | ICL2 | D | 143 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Polar | ICL2 | D | 143 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | D | 143 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | D | 143 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | ICL2 | P | 138 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM6 | M | 244 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | M | 244 | 6x37 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM3 | L | 135 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM3 | R | 131 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | A | 241 | 6x34 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | V | 362 | G.H5.11 |
Hydrophobic | ICL2 | R | 142 | 34x54 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | ICL3 | P | 229 | - | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | ICL3 | P | 229 | - | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | L | 225 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 225 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL3 | A | 231 | - | G.S6 | Y | 343 | G.S6.02 |
Van-der-waals | ICL3 | A | 231 | - | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM6 | K | 240 | 6x33 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM6 | K | 240 | 6x33 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM2 | K | 68 | 2x38 | G.H5 | L | 374 | G.H5.23 |
Polar | TM7 | S | 310 | 7x58 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | S | 310 | 7x58 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | F | 139 | 34x51 | G.S1 | V | 49 | G.S1.02 |
Hydrophobic | TM7 | E | 311 | 7x59 | G.H5 | Q | 377 | G.H5.26 |
Ionic | TM6 | E | 237 | 6x30 | G.H5 | K | 372 | G.H5.21 |
Polar | TM6 | E | 237 | 6x30 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | TM6 | E | 237 | 6x30 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM6 | E | 237 | 6x30 | G.H5 | K | 372 | G.H5.21 |
Hydrophobic | ICL2 | P | 138 | 34x50 | G.H5 | L | 367 | G.H5.16 |