Gi3 - P2RY10 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

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Tertiary structure confidence

(pLDDT score) avg.: 82.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 15.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar ICL3 A 231 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 A 231 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 A 231 - G.H5 D 341 G.H5.13
Polar ICL2 R 140 34x52 G.HN G 27 G.HN.51
Hydrophobic ICL2 R 140 34x52 G.HN G 27 G.HN.51
Van-der-waals ICL2 R 140 34x52 G.HN G 27 G.HN.51
Hydrophobic ICL3 M 230 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL3 M 230 - G.s2s3 K 192 G.s2s3.01
Polar ICL2 F 139 34x51 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 F 139 34x51 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 F 139 34x51 G.hns1 A 31 G.hns1.02
Polar ICL2 R 142 34x54 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 R 142 34x54 G.h2s4 T 219 G.h2s4.05
Van-der-waals ICL2 R 142 34x54 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL3 A 231 - G.H5 I 344 G.H5.16
Van-der-waals ICL3 A 231 - G.H5 I 344 G.H5.16
Polar TM7 S 310 7x58 G.H5 Y 354 G.H5.26
Hydrophobic TM7 S 310 7x58 G.H5 Y 354 G.H5.26
Van-der-waals TM7 S 310 7x58 G.H5 Y 354 G.H5.26
Hydrophobic ICL2 F 139 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 139 34x51 G.H5 I 343 G.H5.15
Polar ICL2 R 142 34x54 G.h2s4 V 218 G.h2s4.04
Hydrophobic ICL2 R 142 34x54 G.h2s4 V 218 G.h2s4.04
Van-der-waals ICL2 R 142 34x54 G.h2s4 V 218 G.h2s4.04
Hydrophobic TM3 F 134 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 F 134 3x53 G.H5 C 351 G.H5.23
Hydrophobic ICL2 F 139 34x51 G.S1 E 33 G.S1.01
Van-der-waals ICL2 F 139 34x51 G.S1 E 33 G.S1.01
Polar ICL2 R 142 34x54 G.h2s4 G 217 G.h2s4.03
Van-der-waals ICL2 R 142 34x54 G.h2s4 G 217 G.h2s4.03
Hydrophobic ICL2 F 139 34x51 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 131 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 139 34x51 G.S1 V 34 G.S1.02
Van-der-waals ICL2 F 139 34x51 G.S1 V 34 G.S1.02
Hydrophobic ICL2 P 138 34x50 G.H5 L 348 G.H5.20
Hydrophobic TM6 F 232 6x25 G.H5 Y 354 G.H5.26
Hydrophobic TM3 L 135 3x54 G.H5 L 353 G.H5.25
Polar TM2 N 67 2x37 G.H5 G 352 G.H5.24
Hydrophobic TM2 N 67 2x37 G.H5 G 352 G.H5.24
Van-der-waals TM2 N 67 2x37 G.H5 G 352 G.H5.24
Polar ICL2 R 140 34x52 G.HN R 24 G.HN.48
Ionic ICL1 K 66 - G.h3s5 E 261 G.h3s5.02
Polar ICL1 K 66 - G.h3s5 E 261 G.h3s5.02
Hydrophobic ICL1 K 66 - G.h3s5 E 261 G.h3s5.02
Van-der-waals ICL1 K 66 - G.h3s5 E 261 G.h3s5.02
Van-der-waals TM7 M 308 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM6 E 237 6x30 G.H5 Y 354 G.H5.26
Van-der-waals TM6 E 237 6x30 G.H5 Y 354 G.H5.26
Hydrophobic TM3 K 137 3x56 G.hns1 A 31 G.hns1.02
Polar ICL3 A 231 - G.H5 Y 354 G.H5.26
Hydrophobic ICL2 F 139 34x51 G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 F 139 34x51 G.h2s4 T 219 G.h2s4.05
Hydrophobic ICL2 F 139 34x51 G.H5 N 347 G.H5.19
Van-der-waals ICL2 F 139 34x51 G.H5 N 347 G.H5.19
Hydrophobic ICL2 F 139 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 139 34x51 G.S3 L 194 G.S3.01
Ionic ICL2 R 140 34x52 G.HN E 28 G.HN.52
Hydrophobic ICL2 R 140 34x52 G.HN E 28 G.HN.52
Van-der-waals ICL2 R 140 34x52 G.HN E 28 G.HN.52
Hydrophobic TM6 M 244 6x37 G.H5 L 353 G.H5.25
Van-der-waals TM6 M 244 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 F 134 3x53 G.H5 L 353 G.H5.25
Ionic ICL2 R 142 34x54 G.H5 E 350 G.H5.22
Polar ICL2 R 140 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 R 140 34x52 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 R 140 34x52 G.hns1 A 31 G.hns1.02
Hydrophobic TM6 F 232 6x25 G.H5 L 348 G.H5.20
Van-der-waals TM6 F 232 6x25 G.H5 L 348 G.H5.20
Polar ICL3 M 230 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 230 - G.H5 D 341 G.H5.13
Van-der-waals ICL3 M 230 - G.H5 D 341 G.H5.13
Hydrophobic ICL3 M 230 - G.H5 D 337 G.H5.09
Van-der-waals ICL3 M 230 - G.H5 D 337 G.H5.09
Hydrophobic ICL2 P 138 34x50 G.H5 N 347 G.H5.19
Ionic TM3 K 137 3x56 G.HN E 28 G.HN.52
Polar TM3 K 137 3x56 G.HN E 28 G.HN.52
Hydrophobic TM3 K 137 3x56 G.HN E 28 G.HN.52
Van-der-waals TM3 K 137 3x56 G.HN E 28 G.HN.52
Hydrophobic TM6 M 244 6x37 G.H5 G 352 G.H5.24
Van-der-waals TM6 M 244 6x37 G.H5 G 352 G.H5.24
Hydrophobic ICL2 A 141 34x53 G.H5 C 351 G.H5.23
Van-der-waals ICL2 A 141 34x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 L 135 3x54 G.H5 L 348 G.H5.20