Go - P2Y12 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 17.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM6 K 232 6x32 G.h4s6 N 316 G.h4s6.10
Polar TM3 R 122 3x50 G.H5 G 352 G.H5.24
Polar TM3 K 125 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 K 125 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 K 125 3x53 G.H5 C 351 G.H5.23
Polar TM6 N 235 6x35 G.H5 Y 354 G.H5.26
Hydrophobic TM6 N 235 6x35 G.H5 Y 354 G.H5.26
Van-der-waals TM6 N 235 6x35 G.H5 Y 354 G.H5.26
Ionic ICL3 K 228 - G.H4 E 309 G.H4.16
Polar ICL3 K 228 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 K 228 - G.H4 E 309 G.H4.16
Hydrophobic ICL2 T 132 34x53 G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 T 132 34x53 G.hns1 A 31 G.hns1.02
Polar ICL2 P 129 34x50 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 129 34x50 G.H5 N 347 G.H5.19
Van-der-waals ICL2 P 129 34x50 G.H5 N 347 G.H5.19
Hydrophobic TM5 T 223 5x72 G.H5 D 341 G.H5.13
Van-der-waals TM5 T 223 5x72 G.H5 D 341 G.H5.13
Hydrophobic TM6 K 237 6x37 G.H5 G 352 G.H5.24
Van-der-waals TM6 K 237 6x37 G.H5 G 352 G.H5.24
Polar TM6 K 232 6x32 G.H5 Y 354 G.H5.26
Van-der-waals TM6 K 232 6x32 G.H5 Y 354 G.H5.26
Hydrophobic TM5 L 216 5x65 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 216 5x65 G.H5 L 348 G.H5.20
Ionic H8 K 303 8x48 G.h3s5 D 262 G.h3s5.02
Polar H8 K 303 8x48 G.h3s5 D 262 G.h3s5.02
Hydrophobic TM3 R 122 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 122 3x50 G.H5 L 353 G.H5.25
Polar TM3 R 122 3x50 G.H5 C 351 G.H5.23
Hydrophobic TM3 R 122 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 122 3x50 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 135 34x56 G.HN I 28 G.HN.52
Van-der-waals ICL2 P 135 34x56 G.HN I 28 G.HN.52
Ionic ICL1 R 54 - G.HN E 20 G.HN.44
Polar ICL1 R 54 - G.HN E 20 G.HN.44
Van-der-waals ICL1 R 54 - G.HN E 20 G.HN.44
Hydrophobic TM3 T 126 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 T 126 3x54 G.H5 L 348 G.H5.20
Polar TM3 K 125 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 K 125 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 K 125 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM6 N 235 6x35 G.H5 L 353 G.H5.25
Polar ICL2 T 132 34x53 G.HN I 28 G.HN.52
Hydrophobic ICL2 T 132 34x53 G.HN I 28 G.HN.52
Van-der-waals ICL2 T 132 34x53 G.HN I 28 G.HN.52
Polar TM5 S 219 5x68 G.H5 D 341 G.H5.13
Hydrophobic TM5 S 219 5x68 G.H5 D 341 G.H5.13
Van-der-waals TM5 S 219 5x68 G.H5 D 341 G.H5.13
Hydrophobic ICL2 N 134 34x55 G.HN I 28 G.HN.52
Hydrophobic ICL2 F 130 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 F 130 34x51 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 129 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 129 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM6 V 238 6x38 G.H5 L 353 G.H5.25
Van-der-waals TM6 V 238 6x38 G.H5 L 353 G.H5.25
Hydrophobic ICL2 F 130 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM5 T 223 5x72 G.S6 Y 320 G.S6.02
Van-der-waals TM5 T 223 5x72 G.S6 Y 320 G.S6.02
Van-der-waals ICL3 K 228 - G.H4 Q 305 G.H4.12
Ionic TM6 K 232 6x32 G.h4s6 E 318 G.h4s6.12
Polar TM6 K 232 6x32 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 K 232 6x32 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 K 232 6x32 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 F 130 34x51 G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 130 34x51 G.S3 L 195 G.S3.01
Hydrophobic TM7 L 301 7x56 G.H5 C 351 G.H5.23
Van-der-waals TM7 L 301 7x56 G.H5 C 351 G.H5.23
Hydrophobic ICL2 P 129 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM5 E 215 5x64 G.H5 I 344 G.H5.16
Polar TM7 L 301 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 L 301 7x56 G.H5 G 352 G.H5.24
Van-der-waals TM7 L 301 7x56 G.H5 G 352 G.H5.24
Hydrophobic TM7 F 300 7x55 G.H5 G 352 G.H5.24
Ionic TM5 R 222 5x71 G.H5 D 337 G.H5.09
Polar TM5 R 222 5x71 G.H5 D 337 G.H5.09
Hydrophobic ICL2 P 135 34x56 G.HN K 24 G.HN.48
Hydrophobic TM3 T 126 3x54 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 216 5x65 G.H5 Y 354 G.H5.26