G13 - P2Y13 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.3


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 145 3x54 G.H5 M 375 G.H5.24
Hydrophobic H8 K 322 8x48 G.h3s5 N 283 G.h3s5.02
Van-der-waals H8 K 322 8x48 G.h3s5 N 283 G.h3s5.02
Ionic C-term D 349 - G.H3 R 279 G.H3.16
Polar C-term D 349 - G.H3 R 279 G.H3.16
Hydrophobic C-term L 353 - G.H3 I 271 G.H3.08
Hydrophobic ICL3 S 242 - G.H5 D 364 G.H5.13
Hydrophobic TM6 L 253 6x34 G.H5 K 372 G.H5.21
Van-der-waals TM6 L 253 6x34 G.H5 K 372 G.H5.21
Hydrophobic C-term I 351 - G.H3 T 274 G.H3.11
Ionic TM6 E 254 6x35 G.H5 H 368 G.H5.17
Polar TM6 E 254 6x35 G.H5 H 368 G.H5.17
Hydrophobic TM6 E 254 6x35 G.H5 H 368 G.H5.17
Van-der-waals TM6 E 254 6x35 G.H5 H 368 G.H5.17
Polar TM3 R 141 3x50 G.H5 M 375 G.H5.24
Van-der-waals TM3 R 141 3x50 G.H5 M 375 G.H5.24
Hydrophobic C-term L 353 - G.H2 R 230 G.H2.04
Van-der-waals C-term L 353 - G.H2 R 230 G.H2.04
Hydrophobic C-term I 351 - G.H3 N 278 G.H3.15
Van-der-waals C-term I 351 - G.H3 N 278 G.H3.15
Polar TM6 N 249 6x30 G.h4s6 Q 339 G.h4s6.13
Van-der-waals TM6 N 249 6x30 G.h4s6 Q 339 G.h4s6.13
Polar TM6 S 244 6x25 G.S6 Y 343 G.S6.02
Hydrophobic TM6 S 244 6x25 G.S6 Y 343 G.S6.02
Van-der-waals TM6 S 244 6x25 G.S6 Y 343 G.S6.02
Hydrophobic ICL3 S 242 - G.H5 T 365 G.H5.14
Polar TM5 S 238 5x68 G.H5 H 368 G.H5.17
Hydrophobic TM5 S 238 5x68 G.H5 H 368 G.H5.17
Van-der-waals TM5 S 238 5x68 G.H5 H 368 G.H5.17
Hydrophobic TM5 K 234 5x64 G.H5 L 371 G.H5.20
Polar TM3 R 147 3x56 G.hns1 R 47 G.hns1.03
Van-der-waals TM3 R 147 3x56 G.hns1 R 47 G.hns1.03
Ionic C-term E 342 - G.H3 R 279 G.H3.16
Hydrophobic C-term L 353 - G.H2 W 233 G.H2.07
Van-der-waals C-term L 353 - G.H2 W 233 G.H2.07
Hydrophobic ICL3 K 241 - G.H5 D 364 G.H5.13
Hydrophobic ICL2 L 149 34x51 G.s2s3 N 215 G.s2s3.02
Van-der-waals ICL2 L 149 34x51 G.s2s3 N 215 G.s2s3.02
Hydrophobic ICL2 P 148 34x50 G.H5 L 374 G.H5.23
Hydrophobic TM5 V 235 5x65 G.H5 L 371 G.H5.20
Polar TM5 Y 239 5x69 G.H5 H 368 G.H5.17
Hydrophobic TM5 Y 239 5x69 G.H5 H 368 G.H5.17
Polar ICL2 L 149 34x51 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 L 149 34x51 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 L 149 34x51 G.hns1 R 47 G.hns1.03
Hydrophobic TM7 L 320 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 L 320 7x56 G.H5 L 376 G.H5.25
Hydrophobic C-term L 353 - G.H3 I 275 G.H3.12
Polar ICL2 R 150 34x52 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 R 150 34x52 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 R 150 34x52 G.hns1 R 47 G.hns1.03
Polar C-term G 354 - G.H2 R 230 G.H2.04
Van-der-waals C-term G 354 - G.H2 R 230 G.H2.04
Hydrophobic TM2 F 78 2x39 G.H5 Q 377 G.H5.26
Van-der-waals TM2 F 78 2x39 G.H5 Q 377 G.H5.26
Hydrophobic TM6 L 253 6x34 G.H5 L 376 G.H5.25
Van-der-waals TM6 L 253 6x34 G.H5 L 376 G.H5.25
Hydrophobic TM5 V 235 5x65 G.H5 M 375 G.H5.24
Van-der-waals TM5 V 235 5x65 G.H5 M 375 G.H5.24
Polar H8 K 322 8x48 G.H5 L 376 G.H5.25
Hydrophobic ICL2 L 149 34x51 G.S3 V 216 G.S3.01
Polar TM6 N 250 6x31 G.H5 K 372 G.H5.21
Hydrophobic TM6 N 250 6x31 G.H5 K 372 G.H5.21
Van-der-waals TM6 N 250 6x31 G.H5 K 372 G.H5.21
Polar C-term G 354 - G.H2 R 227 G.H2.01
Hydrophobic C-term G 354 - G.H2 R 227 G.H2.01
Van-der-waals C-term G 354 - G.H2 R 227 G.H2.01
Hydrophobic TM3 I 145 3x54 G.H5 L 371 G.H5.20
Van-der-waals TM3 I 145 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM5 S 238 5x68 G.H5 L 371 G.H5.20
Van-der-waals TM5 S 238 5x68 G.H5 L 371 G.H5.20
Polar TM7 L 320 7x56 G.H5 Q 377 G.H5.26
Hydrophobic C-term L 353 - G.H3 T 274 G.H3.11
Hydrophobic ICL2 K 155 34x57 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 K 155 34x57 G.hns1 R 47 G.hns1.03
Polar ICL3 S 242 - G.H5 H 368 G.H5.17
Hydrophobic ICL3 S 242 - G.H5 H 368 G.H5.17
Van-der-waals ICL3 S 242 - G.H5 H 368 G.H5.17
Hydrophobic TM6 V 257 6x38 G.H5 M 375 G.H5.24
Van-der-waals TM6 V 257 6x38 G.H5 M 375 G.H5.24
Hydrophobic C-term I 351 - G.h2s4 F 237 G.h2s4.01
Hydrophobic TM6 K 256 6x37 G.H5 L 376 G.H5.25
Polar ICL2 P 148 34x50 G.hns1 R 47 G.hns1.03
Hydrophobic ICL2 P 148 34x50 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 P 148 34x50 G.hns1 R 47 G.hns1.03
Polar TM6 D 246 6x27 G.h4s6 P 341 G.h4s6.20
Hydrophobic TM6 D 246 6x27 G.h4s6 P 341 G.h4s6.20
Van-der-waals TM6 D 246 6x27 G.h4s6 P 341 G.h4s6.20
Polar TM6 N 250 6x31 G.H5 H 368 G.H5.17
Hydrophobic TM6 N 250 6x31 G.H5 H 368 G.H5.17
Van-der-waals TM6 N 250 6x31 G.H5 H 368 G.H5.17
Hydrophobic ICL2 L 149 34x51 G.S3 P 217 G.S3.02
Van-der-waals ICL2 L 149 34x51 G.S3 P 217 G.S3.02
Polar TM3 K 144 3x53 G.H5 Q 377 G.H5.26
Hydrophobic TM3 K 144 3x53 G.H5 Q 377 G.H5.26
Van-der-waals TM3 K 144 3x53 G.H5 Q 377 G.H5.26