Gi1 -
P2Y13 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.5
PAE mean: 15.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | E | 254 | 6x35 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | E | 254 | 6x35 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | C-term | I | 351 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | I | 351 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | L | 149 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | N | 347 | G.H5.19 |
Ionic | ICL2 | R | 150 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 150 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 150 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 150 | 34x52 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | TM5 | Y | 239 | 5x69 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | V | 235 | 5x65 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM5 | I | 231 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | I | 231 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | F | 258 | 6x39 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | I | 351 | - | G.H3 | N | 256 | G.H3.15 |
Van-der-waals | C-term | I | 351 | - | G.H3 | N | 256 | G.H3.15 |
Hydrophobic | C-term | I | 351 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | I | 351 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM6 | K | 245 | 6x26 | G.S6 | F | 323 | G.S6.05 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 145 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | K | 144 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | K | 251 | 6x32 | G.h4s6 | K | 317 | G.h4s6.11 |
Van-der-waals | TM7 | L | 320 | 7x56 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | L | 253 | 6x34 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | R | 141 | 3x50 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 149 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Ionic | TM6 | K | 251 | 6x32 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 251 | 6x32 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 251 | 6x32 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | K | 234 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL1 | S | 75 | - | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL1 | S | 75 | - | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 148 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | N | 151 | 34x53 | G.HN | E | 28 | G.HN.52 |
Ionic | C-term | D | 349 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | TM4 | P | 157 | 4x39 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | P | 157 | 4x39 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM6 | V | 257 | 6x38 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM6 | V | 257 | 6x38 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL1 | P | 73 | - | G.HN | D | 20 | G.HN.44 |
Van-der-waals | ICL1 | P | 73 | - | G.HN | D | 20 | G.HN.44 |
Hydrophobic | ICL2 | P | 148 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | TM4 | K | 161 | 4x43 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL3 | S | 242 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | ICL3 | S | 242 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL3 | S | 242 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | S | 242 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | I | 351 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM5 | V | 235 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | V | 235 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM5 | V | 235 | 5x65 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | K | 251 | 6x32 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM6 | K | 251 | 6x32 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | K | 251 | 6x32 | G.h4s6 | K | 314 | G.h4s6.08 |
Polar | ICL1 | S | 74 | - | G.HN | R | 24 | G.HN.48 |
Van-der-waals | ICL1 | S | 74 | - | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | I | 145 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM4 | P | 157 | 4x39 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | P | 157 | 4x39 | G.HN | R | 24 | G.HN.48 |
Ionic | TM6 | D | 246 | 6x27 | G.h4s6 | K | 314 | G.h4s6.08 |
Polar | C-term | Q | 347 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | Q | 347 | - | G.H3 | K | 257 | G.H3.16 |
Ionic | ICL3 | K | 241 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | K | 241 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | K | 241 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | K | 241 | - | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | K | 251 | 6x32 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM6 | K | 251 | 6x32 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | K | 251 | 6x32 | G.h4s6 | D | 315 | G.h4s6.09 |
Polar | TM6 | K | 256 | 6x37 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | K | 256 | 6x37 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | K | 256 | 6x37 | G.H5 | G | 352 | G.H5.24 |
Polar | C-term | G | 354 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | G | 354 | - | G.H2 | R | 208 | G.H2.04 |
Polar | TM6 | K | 245 | 6x26 | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | TM6 | K | 245 | 6x26 | G.H4 | Q | 304 | G.H4.12 |
Van-der-waals | TM6 | K | 245 | 6x26 | G.H4 | Q | 304 | G.H4.12 |
Polar | TM6 | E | 254 | 6x35 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | E | 254 | 6x35 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | E | 254 | 6x35 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | V | 257 | 6x38 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | V | 257 | 6x38 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM6 | V | 257 | 6x38 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM3 | I | 145 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL2 | N | 151 | 34x53 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | N | 151 | 34x53 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | N | 151 | 34x53 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | L | 149 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | C-term | G | 354 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | C-term | G | 354 | - | G.H2 | R | 205 | G.H2.01 |
Van-der-waals | C-term | G | 354 | - | G.H2 | R | 205 | G.H2.01 |
Polar | TM6 | N | 249 | 6x30 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | TM6 | N | 249 | 6x30 | G.h4s6 | D | 315 | G.h4s6.09 |
Hydrophobic | TM3 | K | 144 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | L | 149 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | C-term | L | 353 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | L | 353 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | TM6 | E | 254 | 6x35 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | C-term | L | 353 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | L | 353 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | C-term | L | 353 | - | G.H3 | L | 249 | G.H3.08 |
Polar | TM3 | R | 141 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 141 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 141 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | V | 257 | 6x38 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | V | 257 | 6x38 | G.H5 | L | 353 | G.H5.25 |