G15 -
P2Y14 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | TM2 | K | 54 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Polar | TM2 | K | 54 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM2 | K | 54 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | TM2 | K | 54 | 2x37 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM5 | I | 213 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | I | 213 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL3 | L | 218 | - | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | ICL3 | L | 218 | - | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | L | 127 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL3 | L | 218 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | ICL3 | L | 218 | - | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 127 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 126 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM5 | H | 217 | 5x69 | G.H5 | L | 374 | G.H5.26 |
Polar | TM5 | S | 216 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | C-term | R | 327 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | C-term | R | 327 | - | G.H3 | P | 265 | G.H3.16 |
Van-der-waals | C-term | R | 327 | - | G.H3 | P | 265 | G.H3.16 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | C-term | L | 338 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | C-term | L | 338 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | T | 331 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | T | 331 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | C-term | T | 331 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | T | 331 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | L | 338 | - | G.H3 | I | 261 | G.H3.12 |
Hydrophobic | TM5 | H | 217 | 5x69 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | H | 217 | 5x69 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | R | 327 | - | G.H3 | W | 266 | G.H3.17 |
Aromatic | C-term | R | 327 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | C-term | R | 327 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | R | 327 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 127 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | C-term | S | 334 | - | G.H3 | W | 266 | G.H3.17 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | C-term | S | 334 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Polar | TM7 | F | 297 | 7x55 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM7 | F | 297 | 7x55 | G.H5 | N | 372 | G.H5.24 |
Polar | TM6 | K | 230 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | K | 230 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | K | 230 | 6x33 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | L | 338 | - | G.H3 | L | 257 | G.H3.08 |
Van-der-waals | C-term | L | 338 | - | G.H3 | L | 257 | G.H3.08 |
Ionic | C-term | D | 319 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Polar | C-term | D | 319 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | C-term | D | 319 | - | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | C-term | T | 335 | - | G.H2 | I | 220 | G.H2.08 |
Van-der-waals | C-term | T | 335 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | ICL2 | P | 126 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 126 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Polar | TM6 | N | 234 | 6x37 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | N | 234 | 6x37 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | V | 227 | 6x30 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | V | 227 | 6x30 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | L | 127 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | C-term | L | 338 | - | G.H3 | T | 260 | G.H3.11 |
Hydrophobic | C-term | L | 338 | - | G.H2 | W | 219 | G.H2.07 |
Polar | TM6 | K | 230 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | K | 230 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | K | 230 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | S | 216 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | S | 216 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Polar | TM6 | S | 231 | 6x34 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | S | 231 | 6x34 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | S | 231 | 6x34 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | N | 234 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | N | 234 | 6x37 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | I | 123 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Aromatic | TM5 | H | 217 | 5x69 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM7 | L | 298 | 7x56 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM7 | L | 298 | 7x56 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM5 | I | 213 | 5x65 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | I | 123 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | C-term | T | 337 | - | G.H3 | T | 260 | G.H3.11 |
Polar | H8 | Q | 300 | 8x48 | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM5 | K | 212 | 5x64 | G.H5 | L | 364 | G.H5.16 |
Polar | ICL2 | T | 129 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | T | 129 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | T | 129 | 34x53 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | C-term | L | 338 | - | G.H2 | R | 216 | G.H2.04 |
Van-der-waals | C-term | L | 338 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | TM3 | K | 122 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | H8 | R | 303 | 8x51 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | R | 303 | 8x51 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | R | 303 | 8x51 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | K | 230 | 6x33 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | C-term | Q | 317 | - | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | ICL2 | W | 128 | 34x52 | G.s2s3 | K | 201 | G.s2s3.02 |
Hydrophobic | TM6 | I | 235 | 6x38 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | L | 320 | - | G.h3s5 | S | 269 | G.h3s5.02 |