Gs - PAC1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 80.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 12.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Ionic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 381 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 381 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 381 G.H5.13
Polar ICL2 T 258 - G.H5 Q 384 G.H5.16
Hydrophobic ICL2 T 258 - G.H5 Q 384 G.H5.16
Polar TM5 K 334 5x64 G.H5 R 385 G.H5.17
Hydrophobic TM3 L 251 3x54 G.H5 Y 391 G.H5.23
Hydrophobic TM6 L 361 6x48 G.H5 Y 391 G.H5.23
Polar TM3 E 247 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 247 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 331 5x61 G.H5 L 388 G.H5.20
Hydrophobic ICL2 F 259 - G.H5 C 379 G.H5.11
Hydrophobic TM5 L 331 5x61 G.H5 L 394 G.H5.26
Hydrophobic ICL3 M 340 - G.H5 L 394 G.H5.26
Polar TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Hydrophobic TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Van-der-waals TM3 L 255 3x58 G.H5 Q 384 G.H5.16
Aromatic ICL2 F 259 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 259 - G.S1 H 41 G.S1.02
Van-der-waals ICL2 F 259 - G.S1 H 41 G.S1.02
Hydrophobic ICL2 F 259 - G.H5 R 380 G.H5.12
Hydrophobic TM5 K 334 5x64 G.H5 L 388 G.H5.20
Hydrophobic ICL3 M 340 - G.h4s6 Y 358 G.h4s6.20
Van-der-waals ICL3 M 340 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic H8 N 404 8x47 G.H5 E 392 G.H5.24
Van-der-waals H8 N 404 8x47 G.H5 E 392 G.H5.24
Hydrophobic TM3 Y 250 3x53 G.H5 Y 391 G.H5.23
Van-der-waals TM3 Y 250 3x53 G.H5 Y 391 G.H5.23
Aromatic TM2 R 185 2x46 G.H5 Y 391 G.H5.23
Hydrophobic TM2 R 185 2x46 G.H5 Y 391 G.H5.23
Van-der-waals TM2 R 185 2x46 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 T 258 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 T 258 - G.H5 I 383 G.H5.15
Hydrophobic ICL2 T 258 - G.H5 R 380 G.H5.12
Van-der-waals ICL2 T 258 - G.H5 R 380 G.H5.12
Hydrophobic ICL3 D 339 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic ICL2 R 263 - G.HN Q 35 G.HN.52
Van-der-waals ICL2 R 263 - G.HN Q 35 G.HN.52
Hydrophobic TM3 L 255 3x58 G.H5 L 388 G.H5.20
Polar TM6 S 354 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM6 S 354 6x41 G.H5 L 393 G.H5.25
Van-der-waals TM6 S 354 6x41 G.H5 L 393 G.H5.25
Hydrophobic TM2 H 189 2x50 G.H5 Y 391 G.H5.23
Van-der-waals TM2 H 189 2x50 G.H5 Y 391 G.H5.23
Aromatic ICL2 F 259 - G.H5 F 376 G.H5.08
Hydrophobic ICL2 F 259 - G.H5 F 376 G.H5.08
Van-der-waals ICL2 F 259 - G.H5 F 376 G.H5.08
Polar TM2 R 185 2x46 G.H5 Q 390 G.H5.22
Hydrophobic TM2 R 185 2x46 G.H5 Q 390 G.H5.22
Van-der-waals TM2 R 185 2x46 G.H5 Q 390 G.H5.22
Ionic ICL2 E 262 - G.H5 H 387 G.H5.19
Hydrophobic TM5 L 331 5x61 G.H5 L 393 G.H5.25
Van-der-waals TM5 L 331 5x61 G.H5 L 393 G.H5.25
Ionic ICL3 D 339 - G.H5 R 385 G.H5.17
Polar ICL3 D 339 - G.H5 R 385 G.H5.17
Hydrophobic TM7 Y 400 7x57 G.H5 Y 391 G.H5.23
Hydrophobic TM5 L 335 5x65 G.H5 L 394 G.H5.26
Van-der-waals TM5 L 335 5x65 G.H5 L 394 G.H5.26
Hydrophobic ICL2 F 259 - G.H5 I 383 G.H5.15
Van-der-waals ICL2 F 259 - G.H5 I 383 G.H5.15
Hydrophobic TM3 L 254 3x57 G.H5 H 387 G.H5.19
Van-der-waals TM3 L 254 3x57 G.H5 H 387 G.H5.19
Hydrophobic ICL2 F 259 - G.S3 V 217 G.S3.01
Van-der-waals ICL2 F 259 - G.S3 V 217 G.S3.01
Polar H8 G 405 8x48 G.H5 E 392 G.H5.24
Van-der-waals H8 G 405 8x48 G.H5 E 392 G.H5.24
Ionic TM6 R 353 6x40 G.H5 E 392 G.H5.24
Polar ICL3 S 337 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 S 337 - G.H5 R 385 G.H5.17
Hydrophobic TM3 L 251 3x54 G.H5 L 393 G.H5.25
Hydrophobic TM6 L 358 6x45 G.H5 L 393 G.H5.25
Polar TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Van-der-waals TM5 K 334 5x64 G.H5 Q 384 G.H5.16
Hydrophobic TM6 L 357 6x44 G.H5 E 392 G.H5.24
Van-der-waals TM6 L 357 6x44 G.H5 E 392 G.H5.24
Hydrophobic TM6 L 357 6x44 G.H5 L 393 G.H5.25