Gt2 - PAC1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 78.5

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.6


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 F 259 - G.H5 T 340 G.H5.12
Van-der-waals ICL2 F 259 - G.H5 T 340 G.H5.12
Polar ICL2 R 263 - G.HN Q 24 G.HN.48
Hydrophobic ICL2 R 263 - G.HN Q 24 G.HN.48
Van-der-waals ICL2 R 263 - G.HN Q 24 G.HN.48
Hydrophobic TM6 L 358 6x45 G.H5 L 353 G.H5.25
Hydrophobic TM2 R 185 2x46 G.H5 C 351 G.H5.23
Aromatic ICL2 F 259 - G.H5 F 336 G.H5.08
Hydrophobic ICL2 F 259 - G.H5 F 336 G.H5.08
Van-der-waals ICL2 F 259 - G.H5 F 336 G.H5.08
Ionic ICL2 R 263 - G.HN D 28 G.HN.52
Polar ICL2 R 263 - G.HN D 28 G.HN.52
Hydrophobic ICL2 R 263 - G.HN D 28 G.HN.52
Van-der-waals ICL2 R 263 - G.HN D 28 G.HN.52
Polar TM6 S 354 6x41 G.H5 L 353 G.H5.25
Hydrophobic TM6 S 354 6x41 G.H5 L 353 G.H5.25
Van-der-waals TM6 S 354 6x41 G.H5 L 353 G.H5.25
Hydrophobic ICL3 D 339 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 D 339 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 K 334 5x64 G.H5 F 354 G.H5.26
Hydrophobic TM3 L 255 3x58 G.H5 I 344 G.H5.16
Polar TM3 L 254 3x57 G.H5 N 347 G.H5.19
Hydrophobic TM3 L 254 3x57 G.H5 N 347 G.H5.19
Van-der-waals TM3 L 254 3x57 G.H5 N 347 G.H5.19
Hydrophobic ICL2 T 258 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 T 258 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 T 258 - G.H5 I 344 G.H5.16
Hydrophobic ICL2 P 261 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 F 259 - G.H5 I 343 G.H5.15
Hydrophobic ICL2 F 259 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 F 259 - G.S3 L 194 G.S3.01
Hydrophobic ICL3 M 340 - G.H5 F 354 G.H5.26
Van-der-waals ICL3 M 340 - G.H5 F 354 G.H5.26
Hydrophobic C-term L 446 - G.H2 I 212 G.H2.08
Van-der-waals C-term L 446 - G.H2 I 212 G.H2.08
Hydrophobic TM3 L 251 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 L 251 3x54 G.H5 L 353 G.H5.25
Ionic ICL2 R 263 - G.HN E 25 G.HN.49
Hydrophobic ICL2 R 263 - G.HN E 25 G.HN.49
Van-der-waals ICL2 R 263 - G.HN E 25 G.HN.49
Hydrophobic TM3 L 255 3x58 G.H5 L 348 G.H5.20
Van-der-waals TM3 L 255 3x58 G.H5 L 348 G.H5.20
Polar ICL3 G 341 - G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 L 251 3x54 G.H5 C 351 G.H5.23
Van-der-waals TM3 L 251 3x54 G.H5 C 351 G.H5.23
Hydrophobic TM6 L 357 6x44 G.H5 G 352 G.H5.24
Van-der-waals TM6 L 357 6x44 G.H5 G 352 G.H5.24
Hydrophobic TM3 L 255 3x58 G.H5 N 347 G.H5.19
Hydrophobic TM5 I 330 5x60 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 335 5x65 G.H5 F 354 G.H5.26
Van-der-waals TM5 L 335 5x65 G.H5 F 354 G.H5.26
Hydrophobic TM6 L 357 6x44 G.H5 L 353 G.H5.25
Polar TM5 K 334 5x64 G.H5 K 345 G.H5.17
Hydrophobic TM5 K 334 5x64 G.H5 K 345 G.H5.17
Van-der-waals TM5 K 334 5x64 G.H5 K 345 G.H5.17
Polar ICL2 F 259 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 F 259 - G.hns1 K 32 G.hns1.03
Polar ICL3 S 337 - G.h4s6 E 318 G.h4s6.12
Van-der-waals ICL3 S 337 - G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 L 331 5x61 G.H5 F 354 G.H5.26
Hydrophobic TM5 K 334 5x64 G.H5 I 344 G.H5.16
Van-der-waals TM5 K 334 5x64 G.H5 I 344 G.H5.16
Ionic TM2 R 185 2x46 G.H5 D 350 G.H5.22
Polar TM2 R 185 2x46 G.H5 D 350 G.H5.22
Hydrophobic TM2 R 185 2x46 G.H5 D 350 G.H5.22
Van-der-waals TM2 R 185 2x46 G.H5 D 350 G.H5.22
Ionic ICL1 R 179 12x48 G.HN E 20 G.HN.44
Polar ICL1 R 179 12x48 G.HN E 20 G.HN.44
Hydrophobic ICL1 R 179 12x48 G.HN E 20 G.HN.44
Van-der-waals ICL1 R 179 12x48 G.HN E 20 G.HN.44
Hydrophobic TM5 L 331 5x61 G.H5 L 348 G.H5.20
Van-der-waals ICL2 F 259 - G.s2s3 K 192 G.s2s3.01
Polar ICL3 S 337 - G.H5 K 345 G.H5.17
Van-der-waals ICL3 S 337 - G.H5 K 345 G.H5.17
Ionic TM5 K 334 5x64 G.H5 D 341 G.H5.13
Polar TM5 K 334 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 D 341 G.H5.13
Van-der-waals TM5 K 334 5x64 G.H5 D 341 G.H5.13
Hydrophobic TM5 K 334 5x64 G.H5 L 348 G.H5.20
Van-der-waals ICL3 D 339 - G.h4s6 K 314 G.h4s6.08
Polar ICL2 F 260 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 F 260 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 F 260 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 T 258 - G.H5 T 340 G.H5.12