G13 - PAR1 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 82.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL2 M 208 34x51 G.H5 I 366 G.H5.15
Van-der-waals ICL2 M 208 34x51 G.H5 I 366 G.H5.15
Hydrophobic ICL2 P 207 34x50 G.H5 I 366 G.H5.15
Hydrophobic ICL1 K 132 12x49 G.HN M 1 G.HN.01
Hydrophobic ICL2 M 208 34x51 G.H5 V 362 G.H5.11
Hydrophobic ICL2 M 208 34x51 G.S1 V 49 G.S1.02
Van-der-waals ICL2 M 208 34x51 G.S1 V 49 G.S1.02
Hydrophobic C-term L 424 - G.h4s6 R 335 G.h4s6.09
Van-der-waals C-term L 424 - G.h4s6 R 335 G.h4s6.09
Hydrophobic TM2 K 135 2x37 G.H5 Q 373 G.H5.22
Van-der-waals TM2 K 135 2x37 G.H5 Q 373 G.H5.22
Hydrophobic TM7 Y 371 7x53 G.H5 L 376 G.H5.25
Van-der-waals TM7 Y 371 7x53 G.H5 L 376 G.H5.25
Hydrophobic C-term Y 420 - G.H3 I 271 G.H3.08
Hydrophobic ICL2 L 211 34x54 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 L 211 34x54 G.hns1 K 46 G.hns1.02
Hydrophobic C-term L 423 - G.H2 F 234 G.H2.08
Hydrophobic TM5 I 293 5x61 G.H5 M 375 G.H5.24
Van-der-waals C-term T 425 - G.H3 R 279 G.H3.16
Hydrophobic TM7 I 370 7x52 G.H5 L 376 G.H5.25
Van-der-waals TM7 I 370 7x52 G.H5 L 376 G.H5.25
Van-der-waals TM3 D 199 3x49 G.H5 L 374 G.H5.23
Polar TM3 V 205 3x55 G.H5 K 363 G.H5.12
Hydrophobic TM6 L 314 6x37 G.H5 M 375 G.H5.24
Hydrophobic ICL3 V 302 - G.H5 D 364 G.H5.13
Polar TM3 A 203 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM3 A 203 3x53 G.H5 N 370 G.H5.19
Van-der-waals TM3 A 203 3x53 G.H5 N 370 G.H5.19
Hydrophobic TM4 T 215 4x38 G.hns1 K 46 G.hns1.02
Van-der-waals TM4 T 215 4x38 G.hns1 K 46 G.hns1.02
Polar C-term Y 420 - G.H3 E 267 G.H3.04
Van-der-waals C-term Y 420 - G.H3 E 267 G.H3.04
Van-der-waals TM6 S 315 6x38 G.H5 M 375 G.H5.24
Hydrophobic TM3 V 204 3x54 G.H5 L 367 G.H5.16
Hydrophobic TM7 A 374 7x56 G.H5 L 376 G.H5.25
Van-der-waals TM7 A 374 7x56 G.H5 L 376 G.H5.25
Polar TM6 K 307 6x30 G.H5 H 368 G.H5.17
Hydrophobic TM6 K 307 6x30 G.H5 H 368 G.H5.17
Van-der-waals TM6 K 307 6x30 G.H5 H 368 G.H5.17
Hydrophobic ICL2 P 207 34x50 G.H5 L 367 G.H5.16
Hydrophobic H8 S 376 8x48 G.H5 Q 377 G.H5.26
Van-der-waals H8 S 376 8x48 G.H5 Q 377 G.H5.26
Hydrophobic C-term L 423 - G.H2 R 230 G.H2.04
Polar ICL3 A 303 - G.H5 D 364 G.H5.13
Hydrophobic TM6 A 311 6x34 G.H5 M 375 G.H5.24
Van-der-waals TM6 A 311 6x34 G.H5 M 375 G.H5.24
Hydrophobic ICL2 P 207 34x50 G.H5 K 363 G.H5.12
Van-der-waals ICL2 P 207 34x50 G.H5 K 363 G.H5.12
Hydrophobic C-term Y 420 - G.H3 N 270 G.H3.07
Van-der-waals C-term Y 420 - G.H3 N 270 G.H3.07
Hydrophobic TM3 V 204 3x54 G.H5 L 371 G.H5.20
Hydrophobic TM5 L 297 5x65 G.H5 M 375 G.H5.24
Hydrophobic TM6 A 311 6x34 G.H5 L 371 G.H5.20
Hydrophobic C-term S 399 - G.H3 R 279 G.H3.16
Hydrophobic ICL2 L 211 34x54 G.H5 I 366 G.H5.15
Hydrophobic C-term L 423 - G.H3 T 274 G.H3.11
Hydrophobic TM6 L 314 6x37 G.H5 L 376 G.H5.25
Hydrophobic ICL2 M 208 34x51 G.S3 V 216 G.S3.01
Hydrophobic ICL2 M 208 34x51 G.H5 K 363 G.H5.12
Van-der-waals ICL2 M 208 34x51 G.H5 K 363 G.H5.12
Hydrophobic ICL3 V 302 - G.H5 L 367 G.H5.16
Polar C-term Y 397 - G.H3 R 279 G.H3.16
Polar C-term N 398 - G.H3 R 279 G.H3.16
Hydrophobic TM3 V 204 3x54 G.H5 M 375 G.H5.24
Hydrophobic C-term L 424 - G.H3 N 277 G.H3.14
Hydrophobic TM2 A 137 2x39 G.H5 L 374 G.H5.23
Van-der-waals TM2 A 137 2x39 G.H5 L 374 G.H5.23
Polar TM3 R 200 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 200 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 200 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM1 I 128 1x58 G.HN M 1 G.HN.01
Van-der-waals TM1 I 128 1x58 G.HN M 1 G.HN.01
Hydrophobic ICL2 R 214 34x57 G.H5 L 374 G.H5.23
Van-der-waals ICL2 R 214 34x57 G.H5 L 374 G.H5.23
Hydrophobic TM5 L 297 5x65 G.H5 L 371 G.H5.20
Polar TM6 K 307 6x30 G.H5 Q 377 G.H5.26
Hydrophobic TM6 K 307 6x30 G.H5 Q 377 G.H5.26
Van-der-waals TM6 K 307 6x30 G.H5 Q 377 G.H5.26
Hydrophobic TM1 L 129 1x59 G.HN M 1 G.HN.01
Van-der-waals TM1 L 129 1x59 G.HN M 1 G.HN.01
Hydrophobic ICL2 S 212 34x55 G.hns1 R 47 G.hns1.03
Van-der-waals ICL2 S 212 34x55 G.hns1 R 47 G.hns1.03
Hydrophobic TM3 A 203 3x53 G.H5 L 374 G.H5.23
Van-der-waals TM3 A 203 3x53 G.H5 L 374 G.H5.23
Ionic C-term K 422 - G.H2 E 229 G.H2.03
Polar C-term K 422 - G.H2 E 229 G.H2.03
Hydrophobic C-term K 422 - G.H2 E 229 G.H2.03
Van-der-waals C-term K 422 - G.H2 E 229 G.H2.03
Polar TM6 R 310 6x33 G.H5 L 376 G.H5.25
Van-der-waals TM6 R 310 6x33 G.H5 L 376 G.H5.25
Hydrophobic ICL2 S 212 34x55 G.HN T 43 G.HN.52
Polar ICL2 R 214 34x57 G.H5 N 370 G.H5.19
Van-der-waals ICL2 R 214 34x57 G.H5 N 370 G.H5.19
Hydrophobic H8 S 375 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 S 375 8x47 G.H5 L 376 G.H5.25