GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 15.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | V | 204 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | TM3 | V | 204 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM3 | V | 204 | 3x54 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | M | 208 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | M | 208 | 34x51 | G.H5 | R | 367 | G.H5.12 |
Hydrophobic | TM2 | A | 137 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM2 | A | 137 | 2x39 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | L | 211 | 34x54 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | TM7 | Y | 372 | 7x54 | G.H5 | E | 379 | G.H5.24 |
Polar | C-term | Y | 420 | - | G.H2 | R | 215 | G.H2.01 |
Aromatic | C-term | Y | 420 | - | G.H2 | R | 215 | G.H2.01 |
Hydrophobic | C-term | Y | 420 | - | G.H2 | R | 215 | G.H2.01 |
Van-der-waals | C-term | Y | 420 | - | G.H2 | R | 215 | G.H2.01 |
Polar | C-term | L | 423 | - | G.H3 | N | 266 | G.H3.15 |
Van-der-waals | C-term | L | 423 | - | G.H3 | N | 266 | G.H3.15 |
Hydrophobic | ICL2 | M | 208 | 34x51 | G.S3 | F | 206 | G.S3.03 |
Van-der-waals | ICL2 | M | 208 | 34x51 | G.S3 | F | 206 | G.S3.03 |
Polar | ICL2 | Q | 209 | 34x52 | G.s2s3 | D | 202 | G.s2s3.01 |
Polar | H8 | S | 375 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | S | 375 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | S | 375 | 8x47 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | L | 211 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Van-der-waals | ICL2 | L | 211 | 34x54 | G.hns1 | K | 40 | G.hns1.02 |
Ionic | TM6 | R | 310 | 6x33 | G.H5 | E | 379 | G.H5.24 |
Polar | TM6 | R | 310 | 6x33 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | R | 310 | 6x33 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | TM6 | R | 310 | 6x33 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM3 | A | 203 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | A | 203 | 3x53 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM7 | A | 374 | 7x56 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM7 | A | 374 | 7x56 | G.H5 | Y | 378 | G.H5.23 |
Polar | H8 | Q | 379 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | Q | 379 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | Q | 379 | 8x51 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | P | 207 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 207 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Polar | ICL2 | M | 208 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | M | 208 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Van-der-waals | ICL2 | M | 208 | 34x51 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | ICL2 | M | 208 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | M | 208 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Polar | ICL2 | P | 207 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | P | 207 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 207 | 34x50 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | Q | 209 | 34x52 | G.S3 | V | 204 | G.S3.01 |
Hydrophobic | ICL3 | V | 302 | - | G.H5 | R | 372 | G.H5.17 |
Hydrophobic | ICL2 | M | 208 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Van-der-waals | ICL2 | M | 208 | 34x51 | G.H5 | C | 366 | G.H5.11 |
Hydrophobic | C-term | L | 424 | - | G.H3 | S | 262 | G.H3.11 |
Van-der-waals | C-term | L | 424 | - | G.H3 | S | 262 | G.H3.11 |
Hydrophobic | TM3 | V | 204 | 3x54 | G.H5 | L | 380 | G.H5.25 |
Polar | TM3 | R | 200 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 200 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 200 | 3x50 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | P | 207 | 34x50 | G.H5 | Q | 371 | G.H5.16 |
Hydrophobic | ICL2 | M | 208 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Van-der-waals | ICL2 | M | 208 | 34x51 | G.S3 | V | 204 | G.S3.01 |
Polar | ICL2 | R | 214 | 34x57 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | R | 214 | 34x57 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | ICL2 | R | 214 | 34x57 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | ICL2 | P | 207 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 207 | 34x50 | G.H5 | R | 367 | G.H5.12 |
Polar | H8 | S | 376 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | H8 | S | 376 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Van-der-waals | H8 | S | 376 | 8x48 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL2 | L | 211 | 34x54 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | L | 211 | 34x54 | G.H5 | H | 374 | G.H5.19 |
Polar | H8 | S | 376 | 8x48 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | C-term | L | 423 | - | G.H2 | R | 218 | G.H2.04 |
Hydrophobic | TM4 | T | 215 | 4x38 | G.HN | L | 37 | G.HN.52 |
Hydrophobic | ICL2 | L | 211 | 34x54 | G.S1 | H | 43 | G.S1.02 |
Hydrophobic | TM3 | V | 204 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | V | 204 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM5 | L | 297 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | K | 307 | 6x30 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | K | 307 | 6x30 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM2 | K | 135 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Van-der-waals | TM2 | K | 135 | 2x37 | G.H5 | Q | 377 | G.H5.22 |
Polar | TM5 | C | 296 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Van-der-waals | TM5 | C | 296 | 5x64 | G.H5 | Q | 371 | G.H5.16 |
Polar | TM7 | A | 374 | 7x56 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM7 | A | 374 | 7x56 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | TM6 | K | 307 | 6x30 | G.H5 | L | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 307 | 6x30 | G.H5 | L | 381 | G.H5.26 |
Hydrophobic | ICL2 | S | 212 | 34x55 | G.hns1 | A | 41 | G.hns1.03 |
Hydrophobic | TM3 | R | 200 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM3 | R | 200 | 3x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM7 | Y | 373 | 7x55 | G.H5 | E | 379 | G.H5.24 |
Hydrophobic | ICL3 | V | 302 | - | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | ICL3 | V | 302 | - | G.H5 | D | 368 | G.H5.13 |
Polar | TM3 | A | 203 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM3 | A | 203 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | TM3 | A | 203 | 3x53 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | C-term | L | 423 | - | G.H2 | R | 219 | G.H2.05 |
Polar | ICL3 | S | 300 | - | G.H5 | Q | 371 | G.H5.16 |
Polar | C-term | Y | 420 | - | G.H2 | R | 218 | G.H2.04 |
Polar | ICL2 | R | 214 | 34x57 | G.H5 | H | 374 | G.H5.19 |
Aromatic | ICL2 | R | 214 | 34x57 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | ICL2 | R | 214 | 34x57 | G.H5 | H | 374 | G.H5.19 |
Van-der-waals | ICL2 | R | 214 | 34x57 | G.H5 | H | 374 | G.H5.19 |
Hydrophobic | TM6 | A | 311 | 6x34 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM6 | A | 311 | 6x34 | G.H5 | L | 380 | G.H5.25 |
Polar | C-term | T | 425 | - | G.H3 | R | 267 | G.H3.16 |
Hydrophobic | C-term | T | 425 | - | G.H3 | R | 267 | G.H3.16 |
Van-der-waals | C-term | T | 425 | - | G.H3 | R | 267 | G.H3.16 |
Polar | TM3 | D | 199 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM3 | D | 199 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Van-der-waals | TM3 | D | 199 | 3x49 | G.H5 | Y | 378 | G.H5.23 |
Hydrophobic | TM6 | R | 310 | 6x33 | G.H5 | L | 380 | G.H5.25 |