G12 - PAR3 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM2 T 128 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM3 I 195 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 I 195 3x54 G.H5 L 371 G.H5.16
Ionic TM4 K 206 4x38 G.H5 D 377 G.H5.22
Polar TM4 K 206 4x38 G.H5 D 377 G.H5.22
Polar TM3 A 194 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 A 194 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 A 194 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM6 Y 299 6x34 G.H5 M 379 G.H5.24
Van-der-waals TM6 Y 299 6x34 G.H5 M 379 G.H5.24
Van-der-waals C-term T 364 - G.H5 M 379 G.H5.24
Polar C-term Y 371 - G.h4s6 P 345 G.h4s6.20
Hydrophobic C-term Y 371 - G.h4s6 P 345 G.h4s6.20
Van-der-waals C-term Y 371 - G.h4s6 P 345 G.h4s6.20
Hydrophobic TM3 A 194 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 A 194 3x53 G.H5 I 378 G.H5.23
Hydrophobic ICL1 T 123 - G.H5 L 380 G.H5.25
Van-der-waals ICL1 T 123 - G.H5 L 380 G.H5.25
Polar ICL2 R 202 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 202 34x54 G.h2s4 T 246 G.h2s4.05
Van-der-waals ICL2 R 202 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM5 L 289 5x65 G.H5 L 375 G.H5.20
Hydrophobic TM6 W 298 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 W 298 6x33 G.H5 M 379 G.H5.24
Polar C-term Y 371 - G.H5 Q 372 G.H5.17
Polar ICL1 S 125 - G.H5 D 377 G.H5.22
Van-der-waals ICL1 S 125 - G.H5 D 377 G.H5.22
Hydrophobic ICL2 P 198 34x50 G.H5 I 370 G.H5.15
Hydrophobic ICL2 G 203 34x55 G.hns1 R 55 G.hns1.02
Hydrophobic TM3 R 191 3x50 G.H5 I 378 G.H5.23
Polar TM4 K 206 4x38 G.H5 N 374 G.H5.19
Hydrophobic ICL2 P 198 34x50 G.H5 K 367 G.H5.12
Hydrophobic TM5 Y 292 5x68 G.H5 L 371 G.H5.16
Van-der-waals TM5 Y 292 5x68 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 199 34x51 G.S1 V 58 G.S1.02
Hydrophobic ICL2 Y 201 34x53 G.H5 N 374 G.H5.19
Van-der-waals ICL2 Y 201 34x53 G.H5 N 374 G.H5.19
Polar ICL2 R 202 34x54 G.S1 L 57 G.S1.01
Van-der-waals ICL2 P 205 34x57 G.hns1 R 55 G.hns1.02
Ionic ICL3 R 295 - G.H5 D 368 G.H5.13
Polar ICL3 R 295 - G.H5 D 368 G.H5.13
Hydrophobic TM7 M 361 7x56 G.H5 M 379 G.H5.24
Van-der-waals TM7 M 361 7x56 G.H5 M 379 G.H5.24
Hydrophobic ICL1 S 125 - G.H5 L 380 G.H5.25
Hydrophobic TM2 Y 132 2x43 G.H5 L 380 G.H5.25
Polar C-term T 364 - G.H5 Q 381 G.H5.26
Hydrophobic C-term T 364 - G.H5 Q 381 G.H5.26
Van-der-waals C-term T 364 - G.H5 Q 381 G.H5.26
Hydrophobic C-term T 369 - G.h4s6 S 343 G.h4s6.12
Hydrophobic TM7 Y 358 7x53 G.H5 L 380 G.H5.25
Van-der-waals TM7 Y 358 7x53 G.H5 L 380 G.H5.25
Hydrophobic ICL2 F 199 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 199 34x51 G.S3 I 221 G.S3.01
Polar ICL2 R 202 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic TM6 W 296 6x31 G.H5 Q 372 G.H5.17
Van-der-waals TM6 W 296 6x31 G.H5 Q 372 G.H5.17
Polar C-term S 362 - G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 199 34x51 G.S3 F 223 G.S3.03
Ionic ICL2 R 202 34x54 G.H5 E 373 G.H5.18
Hydrophobic TM6 W 296 6x31 G.H5 L 375 G.H5.20
Van-der-waals TM6 W 296 6x31 G.H5 L 375 G.H5.20
Hydrophobic C-term R 365 - G.H5 Q 381 G.H5.26
Hydrophobic ICL2 F 199 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 199 34x51 G.H5 I 370 G.H5.15
Hydrophobic C-term Y 371 - G.h4s6 K 344 G.h4s6.19
Van-der-waals C-term Y 371 - G.h4s6 K 344 G.h4s6.19
Hydrophobic ICL2 F 199 34x51 G.H5 V 366 G.H5.11
Polar ICL2 P 198 34x50 G.H5 N 374 G.H5.19
Aromatic ICL2 F 199 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 199 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 199 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM2 T 128 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM3 I 195 3x54 G.H5 L 375 G.H5.20
Van-der-waals TM3 I 195 3x54 G.H5 L 375 G.H5.20
Polar TM5 Y 292 5x68 G.H5 K 367 G.H5.12
Hydrophobic TM5 Y 292 5x68 G.H5 K 367 G.H5.12
Van-der-waals TM5 Y 292 5x68 G.H5 K 367 G.H5.12
Hydrophobic ICL2 R 202 34x54 G.H5 I 370 G.H5.15
Hydrophobic ICL2 G 203 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 G 203 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic C-term Y 371 - G.h4s6 S 343 G.h4s6.12
Van-der-waals C-term Y 371 - G.h4s6 S 343 G.h4s6.12
Hydrophobic ICL2 F 199 34x51 G.H5 K 367 G.H5.12
Polar TM6 Y 299 6x34 G.H5 L 375 G.H5.20
Hydrophobic TM6 Y 299 6x34 G.H5 L 375 G.H5.20
Van-der-waals TM6 Y 299 6x34 G.H5 L 375 G.H5.20