G14 -
DP2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 16.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | P | 136 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | P | 136 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Polar | TM6 | G | 242 | 6x31 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM6 | G | 242 | 6x31 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM6 | G | 242 | 6x31 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM5 | R | 236 | 5x68 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM5 | R | 236 | 5x68 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM6 | V | 245 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | V | 245 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | Q | 132 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | Q | 132 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | Q | 132 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Polar | TM6 | F | 244 | 6x33 | G.H5 | F | 352 | G.H5.23 |
Aromatic | TM6 | F | 244 | 6x33 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM6 | F | 244 | 6x33 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM6 | F | 244 | 6x33 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | P | 136 | 34x50 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | ICL2 | V | 137 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Ionic | TM5 | R | 236 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | R | 236 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | R | 236 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | R | 236 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | C-term | L | 370 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | W | 372 | - | G.H3 | L | 250 | G.H3.08 |
Polar | C-term | C | 377 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | C | 377 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | C | 377 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | L | 373 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | TM3 | Q | 132 | 3x53 | G.H5 | L | 345 | G.H5.16 |
Polar | ICL2 | Q | 140 | 34x54 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 140 | 34x54 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | V | 137 | 34x51 | G.H5 | K | 341 | G.H5.12 |
Polar | C-term | L | 373 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | L | 373 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | ICL3 | R | 239 | - | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | ICL3 | R | 239 | - | G.H5 | V | 355 | G.H5.26 |
Polar | ICL2 | H | 142 | 34x56 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 140 | 34x54 | G.S1 | L | 36 | G.S1.02 |
Van-der-waals | ICL2 | Q | 140 | 34x54 | G.S1 | L | 36 | G.S1.02 |
Polar | ICL2 | R | 143 | 34x57 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM3 | V | 133 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | S | 380 | - | G.s4h3 | N | 240 | G.s4h3.13 |
Van-der-waals | C-term | S | 380 | - | G.s4h3 | N | 240 | G.s4h3.13 |
Hydrophobic | TM3 | V | 133 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM5 | L | 233 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM5 | L | 233 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | C-term | L | 369 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | C-term | L | 369 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | C-term | L | 370 | - | G.H2 | R | 210 | G.H2.05 |
Hydrophobic | TM3 | Q | 132 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | Q | 132 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Ionic | ICL2 | R | 143 | 34x57 | G.H5 | E | 351 | G.H5.22 |
Polar | ICL2 | R | 143 | 34x57 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | ICL2 | R | 143 | 34x57 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | ICL2 | P | 136 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | L | 369 | - | G.H3 | Y | 257 | G.H3.15 |
Hydrophobic | C-term | L | 373 | - | G.H3 | L | 250 | G.H3.08 |
Van-der-waals | C-term | L | 373 | - | G.H3 | L | 250 | G.H3.08 |
Polar | TM6 | G | 242 | 6x31 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | G | 242 | 6x31 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | G | 242 | 6x31 | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | Q | 132 | 3x53 | G.H5 | E | 351 | G.H5.22 |
Polar | TM6 | F | 244 | 6x33 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM6 | F | 244 | 6x33 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM6 | F | 244 | 6x33 | G.H5 | N | 353 | G.H5.24 |
Polar | C-term | C | 377 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Hydrophobic | C-term | C | 377 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Van-der-waals | C-term | C | 377 | - | G.s4h3 | C | 238 | G.s4h3.11 |
Polar | C-term | G | 375 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | G | 375 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | G | 375 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | TM3 | R | 129 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 129 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | D | 128 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | D | 128 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM5 | L | 233 | 5x65 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | ICL2 | P | 136 | 34x50 | G.H5 | K | 341 | G.H5.12 |
Polar | ICL2 | N | 141 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | N | 141 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | N | 141 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Polar | TM6 | R | 243 | 6x32 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM6 | R | 243 | 6x32 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM6 | R | 243 | 6x32 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL2 | R | 143 | 34x57 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | ICL2 | R | 143 | 34x57 | G.H5 | F | 352 | G.H5.23 |
Aromatic | TM3 | R | 129 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 129 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | L | 374 | - | G.H2 | R | 210 | G.H2.05 |
Van-der-waals | C-term | L | 374 | - | G.H2 | R | 210 | G.H2.05 |
Hydrophobic | TM3 | V | 133 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | V | 133 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM6 | G | 242 | 6x31 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | C-term | W | 372 | - | G.H3 | T | 253 | G.H3.11 |
Van-der-waals | C-term | W | 372 | - | G.H3 | T | 253 | G.H3.11 |
Hydrophobic | TM2 | V | 66 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | V | 66 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | C-term | W | 372 | - | G.H3 | A | 249 | G.H3.07 |
Van-der-waals | C-term | W | 372 | - | G.H3 | A | 249 | G.H3.07 |
Polar | ICL3 | R | 239 | - | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | C-term | P | 366 | - | G.H3 | Y | 257 | G.H3.15 |
Van-der-waals | C-term | P | 366 | - | G.H3 | Y | 257 | G.H3.15 |
Polar | C-term | C | 377 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | ICL2 | Q | 140 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | Q | 140 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | N | 141 | 34x55 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | V | 137 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | V | 137 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Polar | ICL2 | N | 141 | 34x55 | G.s2s3 | N | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | N | 141 | 34x55 | G.s2s3 | N | 194 | G.s2s3.02 |