G15 -
DP2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 76.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.3
PAE mean: 24.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | G | 242 | 6x31 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM6 | G | 242 | 6x31 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM6 | G | 242 | 6x31 | G.H5 | L | 374 | G.H5.26 |
Polar | ICL2 | N | 141 | 34x55 | G.HN | Q | 38 | G.HN.53 |
Hydrophobic | ICL2 | N | 141 | 34x55 | G.HN | Q | 38 | G.HN.53 |
Van-der-waals | ICL2 | N | 141 | 34x55 | G.HN | Q | 38 | G.HN.53 |
Hydrophobic | ICL2 | V | 137 | 34x51 | G.S3 | N | 203 | G.S3.02 |
Van-der-waals | ICL2 | V | 137 | 34x51 | G.S3 | N | 203 | G.S3.02 |
Hydrophobic | ICL2 | V | 137 | 34x51 | G.S3 | L | 204 | G.S3.03 |
Hydrophobic | TM4 | T | 144 | 4x38 | G.HN | K | 37 | G.HN.52 |
Polar | C-term | V | 328 | - | G.H5 | N | 372 | G.H5.24 |
Polar | TM6 | V | 245 | 6x34 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | V | 245 | 6x34 | G.H5 | N | 372 | G.H5.24 |
Polar | C-term | V | 326 | - | G.H5 | N | 372 | G.H5.24 |
Polar | ICL2 | Q | 140 | 34x54 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 140 | 34x54 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 140 | 34x54 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | V | 137 | 34x51 | G.S1 | E | 42 | G.S1.01 |
Polar | TM6 | R | 243 | 6x32 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | R | 129 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | R | 129 | 3x50 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM3 | Q | 132 | 3x53 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | Q | 132 | 3x53 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | D | 329 | - | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | L | 233 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM5 | L | 233 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Polar | C-term | D | 330 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | D | 330 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | C-term | D | 330 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | S | 331 | - | G.h3s5 | S | 269 | G.h3s5.02 |
Hydrophobic | C-term | D | 329 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | C-term | D | 329 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | TM6 | P | 241 | 6x30 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | Q | 140 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Van-der-waals | ICL2 | Q | 140 | 34x54 | G.h2s4 | I | 227 | G.h2s4.05 |
Hydrophobic | ICL2 | Q | 140 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 140 | 34x54 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | V | 137 | 34x51 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | V | 137 | 34x51 | G.hns1 | G | 41 | G.hns1.03 |
Polar | ICL2 | N | 141 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Hydrophobic | ICL2 | N | 141 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL2 | N | 141 | 34x55 | G.hns1 | R | 40 | G.hns1.02 |
Polar | ICL2 | Q | 140 | 34x54 | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | ICL2 | Q | 140 | 34x54 | G.S1 | E | 42 | G.S1.01 |
Van-der-waals | ICL2 | Q | 140 | 34x54 | G.S1 | E | 42 | G.S1.01 |
Polar | TM5 | R | 232 | 5x64 | G.s2s3 | Q | 200 | G.s2s3.01 |
Van-der-waals | TM5 | R | 232 | 5x64 | G.s2s3 | Q | 200 | G.s2s3.01 |
Ionic | C-term | D | 329 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | C-term | D | 329 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | D | 329 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | C-term | D | 329 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | ICL2 | Q | 140 | 34x54 | G.hns1 | D | 39 | G.hns1.01 |
Van-der-waals | ICL2 | Q | 140 | 34x54 | G.hns1 | D | 39 | G.hns1.01 |
Hydrophobic | TM5 | R | 236 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | R | 236 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | ICL2 | P | 136 | 34x50 | G.S3 | T | 202 | G.S3.01 |
Aromatic | C-term | W | 372 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | C-term | W | 372 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | ICL2 | P | 136 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | ICL2 | P | 136 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | L | 233 | 5x65 | G.H5 | L | 374 | G.H5.26 |
Polar | ICL2 | Q | 140 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | Q | 140 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | Q | 140 | 34x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 136 | 34x50 | G.S1 | L | 43 | G.S1.02 |
Polar | ICL2 | P | 136 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 136 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | N | 141 | 34x55 | G.S1 | E | 42 | G.S1.01 |
Hydrophobic | C-term | D | 330 | - | G.h4s6 | A | 334 | G.h4s6.16 |
Hydrophobic | TM3 | Q | 132 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | Q | 132 | 3x53 | G.H5 | I | 371 | G.H5.23 |
Ionic | C-term | R | 340 | - | G.h4s6 | E | 328 | G.h4s6.10 |
Polar | C-term | R | 340 | - | G.h4s6 | E | 328 | G.h4s6.10 |
Hydrophobic | C-term | R | 340 | - | G.h4s6 | E | 328 | G.h4s6.10 |
Van-der-waals | C-term | R | 340 | - | G.h4s6 | E | 328 | G.h4s6.10 |
Hydrophobic | TM3 | V | 133 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | V | 133 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Ionic | TM5 | R | 236 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | R | 236 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | R | 236 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | R | 236 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | ICL2 | N | 141 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | ICL2 | N | 141 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Van-der-waals | ICL2 | N | 141 | 34x55 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | TM3 | Q | 132 | 3x53 | G.H5 | L | 373 | G.H5.25 |
Polar | TM6 | F | 244 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | F | 244 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | F | 244 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | V | 245 | 6x34 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM6 | V | 245 | 6x34 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | C-term | L | 373 | - | G.H2 | K | 217 | G.H2.05 |
Hydrophobic | ICL2 | V | 137 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | V | 137 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | G | 242 | 6x31 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM3 | Q | 132 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Polar | TM5 | R | 236 | 5x68 | G.H5 | R | 360 | G.H5.12 |
Hydrophobic | ICL2 | V | 137 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | V | 137 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM5 | V | 229 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM5 | V | 229 | 5x61 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | TM6 | G | 242 | 6x31 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | S | 331 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | C-term | S | 331 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | C-term | S | 331 | - | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | ICL2 | Q | 140 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | ICL2 | Q | 140 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | Q | 140 | 34x54 | G.S1 | L | 43 | G.S1.02 |
Polar | ICL2 | W | 138 | 34x52 | G.hns1 | G | 41 | G.hns1.03 |
Hydrophobic | TM3 | V | 133 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | TM3 | V | 133 | 3x54 | G.H5 | L | 373 | G.H5.25 |
Polar | ICL2 | Q | 140 | 34x54 | G.h2s4 | N | 225 | G.h2s4.03 |
Polar | C-term | D | 329 | - | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | C-term | D | 329 | - | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM5 | R | 236 | 5x68 | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | TM4 | T | 144 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | TM4 | T | 144 | 4x38 | G.hns1 | R | 40 | G.hns1.02 |
Van-der-waals | ICL3 | R | 240 | - | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | ICL2 | N | 141 | 34x55 | G.HN | K | 37 | G.HN.52 |