G12 - DP1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.8
PAE mean: 14.4


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Van-der-waals TM5 L 232 5x70 G.H5 Q 372 G.H5.17
Hydrophobic ICL2 Y 140 34x53 G.H5 N 374 G.H5.19
Hydrophobic ICL1 L 54 - G.H3 L 285 G.H3.17
Hydrophobic TM6 H 263 6x33 G.H5 M 379 G.H5.24
Van-der-waals TM6 H 263 6x33 G.H5 M 379 G.H5.24
Polar TM6 Q 256 6x26 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM6 Q 256 6x26 G.h4s6 S 343 G.h4s6.12
Van-der-waals TM6 Q 256 6x26 G.h4s6 S 343 G.h4s6.12
Hydrophobic TM2 F 61 2x39 G.H5 I 378 G.H5.23
Van-der-waals TM2 F 61 2x39 G.H5 I 378 G.H5.23
Polar TM3 S 133 3x53 G.H5 N 374 G.H5.19
Hydrophobic TM3 S 133 3x53 G.H5 N 374 G.H5.19
Van-der-waals TM3 S 133 3x53 G.H5 N 374 G.H5.19
Polar ICL2 R 142 34x55 G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 R 142 34x55 G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 R 142 34x55 G.hns1 R 56 G.hns1.03
Polar H8 R 332 8x52 G.H5 Q 381 G.H5.26
Hydrophobic H8 R 332 8x52 G.H5 Q 381 G.H5.26
Van-der-waals H8 R 332 8x52 G.H5 Q 381 G.H5.26
Hydrophobic TM3 L 134 3x54 G.H5 L 371 G.H5.16
Van-der-waals TM3 L 134 3x54 G.H5 L 371 G.H5.16
Hydrophobic TM5 M 228 5x66 G.H5 Q 372 G.H5.17
Van-der-waals TM5 M 228 5x66 G.H5 Q 372 G.H5.17
Hydrophobic TM5 L 232 5x70 G.H5 D 368 G.H5.13
Hydrophobic TM6 E 260 6x30 G.H5 L 375 G.H5.20
Van-der-waals TM6 E 260 6x30 G.H5 L 375 G.H5.20
Polar TM5 S 238 5x76 G.S6 H 348 G.S6.03
Hydrophobic TM5 S 238 5x76 G.S6 H 348 G.S6.03
Van-der-waals TM5 S 238 5x76 G.S6 H 348 G.S6.03
Ionic TM5 D 242 5x80 G.H4 R 329 G.H4.09
Hydrophobic ICL2 F 138 34x51 G.H5 I 370 G.H5.15
Van-der-waals ICL2 F 138 34x51 G.H5 I 370 G.H5.15
Van-der-waals TM4 R 147 4x40 G.HN R 52 G.HN.52
Hydrophobic TM6 E 259 6x29 G.H5 L 375 G.H5.20
Polar TM2 S 59 2x37 G.H5 D 377 G.H5.22
Hydrophobic TM2 S 59 2x37 G.H5 D 377 G.H5.22
Van-der-waals TM2 S 59 2x37 G.H5 D 377 G.H5.22
Hydrophobic ICL2 F 138 34x51 G.S3 F 223 G.S3.03
Hydrophobic TM6 H 263 6x33 G.H5 I 378 G.H5.23
Van-der-waals TM6 H 263 6x33 G.H5 I 378 G.H5.23
Hydrophobic ICL2 F 138 34x51 G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 138 34x51 G.S3 I 221 G.S3.01
Hydrophobic TM2 Y 62 2x40 G.H5 L 380 G.H5.25
Hydrophobic ICL2 P 137 34x50 G.H5 K 367 G.H5.12
Hydrophobic ICL2 P 137 34x50 G.H5 I 370 G.H5.15
Van-der-waals ICL2 P 137 34x50 G.H5 I 370 G.H5.15
Hydrophobic TM5 T 240 5x78 G.H4 R 329 G.H4.09
Van-der-waals TM5 T 240 5x78 G.H4 R 329 G.H4.09
Hydrophobic TM6 E 259 6x29 G.H5 K 376 G.H5.21
Hydrophobic TM3 C 130 3x50 G.H5 I 378 G.H5.23
Van-der-waals TM3 C 130 3x50 G.H5 I 378 G.H5.23
Hydrophobic TM5 L 225 5x63 G.H5 L 375 G.H5.20
Van-der-waals TM5 L 225 5x63 G.H5 L 375 G.H5.20
Hydrophobic ICL2 R 141 34x54 G.H5 I 370 G.H5.15
Hydrophobic TM5 H 235 5x73 G.H5 F 361 G.H5.06
Hydrophobic TM5 L 232 5x70 G.S6 F 347 G.S6.02
Hydrophobic ICL2 F 138 34x51 G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 138 34x51 G.S1 V 58 G.S1.02
Hydrophobic H8 R 327 8x47 G.H5 M 379 G.H5.24
Hydrophobic TM1 L 41 1x57 G.H5 L 380 G.H5.25
Aromatic ICL2 F 138 34x51 G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 138 34x51 G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 138 34x51 G.H5 F 363 G.H5.08
Hydrophobic TM2 F 61 2x39 G.H5 D 377 G.H5.22
Hydrophobic TM3 E 129 3x49 G.H5 I 378 G.H5.23
Polar ICL2 R 141 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic ICL2 R 141 34x54 G.h2s4 T 246 G.h2s4.05
Hydrophobic TM5 M 228 5x66 G.H5 L 371 G.H5.16
Van-der-waals TM5 M 228 5x66 G.H5 L 371 G.H5.16
Hydrophobic ICL2 F 138 34x51 G.H5 V 366 G.H5.11
Hydrophobic ICL2 F 138 34x51 G.H5 K 367 G.H5.12
Polar H8 R 332 8x52 G.H5 M 379 G.H5.24
Hydrophobic H8 R 332 8x52 G.H5 M 379 G.H5.24
Van-der-waals H8 R 332 8x52 G.H5 M 379 G.H5.24
Polar H8 R 327 8x47 G.H5 I 378 G.H5.23
Hydrophobic H8 R 327 8x47 G.H5 I 378 G.H5.23
Van-der-waals H8 R 327 8x47 G.H5 I 378 G.H5.23
Hydrophobic ICL2 P 137 34x50 G.H5 L 371 G.H5.16
Hydrophobic TM6 L 266 6x36 G.H5 M 379 G.H5.24
Hydrophobic TM2 V 65 2x43 G.H5 L 380 G.H5.25
Polar TM5 D 242 5x80 G.H4 Q 333 G.H4.13
Polar ICL2 R 141 34x54 G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 R 141 34x54 G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 R 141 34x54 G.hns1 R 55 G.hns1.02
Ionic TM5 R 231 5x69 G.H5 D 368 G.H5.13
Polar TM5 R 231 5x69 G.H5 D 368 G.H5.13
Hydrophobic TM6 H 263 6x33 G.H5 L 375 G.H5.20
Van-der-waals TM6 H 263 6x33 G.H5 L 375 G.H5.20
Hydrophobic TM3 L 134 3x54 G.H5 I 378 G.H5.23
Ionic ICL2 R 141 34x54 G.H5 E 373 G.H5.18
Polar ICL2 R 141 34x54 G.H5 E 373 G.H5.18
Van-der-waals ICL2 R 141 34x54 G.H5 E 373 G.H5.18
Hydrophobic TM2 F 61 2x39 G.H5 L 380 G.H5.25
Hydrophobic TM7 I 324 7x54 G.H5 L 380 G.H5.25
Hydrophobic TM3 L 134 3x54 G.H5 L 375 G.H5.20
Hydrophobic TM3 S 133 3x53 G.H5 I 378 G.H5.23
Van-der-waals TM3 S 133 3x53 G.H5 I 378 G.H5.23