Gi2 -
EP1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | M | 295 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | M | 295 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | S | 394 | - | G.H2 | E | 208 | G.H2.03 |
Van-der-waals | C-term | S | 394 | - | G.H2 | E | 208 | G.H2.03 |
Ionic | TM2 | R | 68 | 2x34 | G.HN | E | 28 | G.HN.52 |
Polar | TM2 | R | 68 | 2x34 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM2 | R | 68 | 2x34 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM2 | R | 68 | 2x34 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM5 | L | 229 | 5x63 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM5 | L | 229 | 5x63 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL2 | A | 147 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | A | 147 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Polar | ICL3 | S | 281 | - | G.H4 | D | 310 | G.H4.17 |
Polar | H8 | R | 355 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | H8 | R | 355 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | R | 355 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Polar | C-term | H | 401 | - | G.H2 | R | 206 | G.H2.01 |
Aromatic | C-term | H | 401 | - | G.H2 | R | 206 | G.H2.01 |
Hydrophobic | C-term | H | 401 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | H | 401 | - | G.H2 | R | 206 | G.H2.01 |
Van-der-waals | C-term | F | 402 | - | G.H1 | K | 46 | G.H1.01 |
Ionic | TM5 | R | 236 | 5x70 | G.H5 | D | 342 | G.H5.13 |
Polar | TM5 | R | 236 | 5x70 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | R | 236 | 5x70 | G.H5 | D | 342 | G.H5.13 |
Ionic | TM6 | R | 287 | 6x25 | G.h4s6 | D | 316 | G.h4s6.09 |
Polar | TM6 | R | 287 | 6x25 | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | TM6 | R | 287 | 6x25 | G.h4s6 | D | 316 | G.h4s6.09 |
Van-der-waals | TM6 | R | 287 | 6x25 | G.h4s6 | D | 316 | G.h4s6.09 |
Polar | ICL2 | H | 145 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | H | 145 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | H | 145 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Polar | C-term | S | 397 | - | G.H2 | E | 208 | G.H2.03 |
Polar | TM3 | R | 135 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 135 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 135 | 3x50 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | C-term | W | 386 | - | G.H3 | W | 259 | G.H3.17 |
Ionic | TM5 | R | 236 | 5x70 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM5 | R | 236 | 5x70 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM5 | R | 236 | 5x70 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM5 | R | 236 | 5x70 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | C-term | F | 402 | - | G.H3 | L | 250 | G.H3.08 |
Van-der-waals | C-term | F | 402 | - | G.H3 | L | 250 | G.H3.08 |
Polar | TM5 | R | 236 | 5x70 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | C-term | L | 399 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Aromatic | C-term | W | 386 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | C-term | W | 386 | - | G.H3 | K | 258 | G.H3.16 |
Van-der-waals | C-term | W | 386 | - | G.H3 | K | 258 | G.H3.16 |
Hydrophobic | TM3 | R | 135 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 135 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | ICL2 | P | 142 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Aromatic | TM6 | H | 291 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | TM6 | H | 291 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | H | 291 | 6x29 | G.H5 | F | 355 | G.H5.26 |
Polar | TM3 | G | 138 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | G | 138 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | G | 138 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Polar | C-term | S | 400 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | S | 400 | - | G.H2 | R | 209 | G.H2.04 |
Ionic | C-term | H | 401 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Polar | C-term | H | 401 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | H | 401 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Van-der-waals | C-term | H | 401 | - | G.s4h3 | E | 237 | G.s4h3.10 |
Hydrophobic | C-term | F | 402 | - | G.s1h1 | G | 40 | G.s1h1.01 |
Van-der-waals | C-term | F | 402 | - | G.s1h1 | G | 40 | G.s1h1.01 |
Polar | TM2 | R | 68 | 2x34 | G.HN | G | 27 | G.HN.51 |
Hydrophobic | TM2 | R | 68 | 2x34 | G.HN | G | 27 | G.HN.51 |
Van-der-waals | TM2 | R | 68 | 2x34 | G.HN | G | 27 | G.HN.51 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | L | 143 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Polar | TM2 | R | 68 | 2x34 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM2 | F | 73 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | F | 73 | 2x39 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM6 | M | 295 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | F | 402 | - | G.s3h2 | G | 204 | G.s3h2.02 |
Hydrophobic | C-term | F | 402 | - | G.s3h2 | G | 204 | G.s3h2.02 |
Van-der-waals | C-term | F | 402 | - | G.s3h2 | G | 204 | G.s3h2.02 |
Hydrophobic | C-term | F | 402 | - | G.s1h1 | G | 42 | G.s1h1.03 |
Van-der-waals | C-term | F | 402 | - | G.s1h1 | G | 42 | G.s1h1.03 |
Hydrophobic | TM6 | L | 299 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | TM2 | S | 69 | 2x35 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM2 | S | 69 | 2x35 | G.H5 | D | 351 | G.H5.22 |
Van-der-waals | TM2 | S | 69 | 2x35 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM2 | R | 68 | 2x34 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL3 | S | 281 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Van-der-waals | ICL3 | S | 281 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Hydrophobic | C-term | F | 402 | - | G.H2 | R | 209 | G.H2.04 |
Van-der-waals | C-term | F | 402 | - | G.H2 | R | 209 | G.H2.04 |
Hydrophobic | C-term | S | 400 | - | G.H3 | E | 246 | G.H3.04 |
Van-der-waals | C-term | S | 400 | - | G.H3 | E | 246 | G.H3.04 |
Hydrophobic | ICL2 | P | 142 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | P | 142 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Polar | C-term | S | 390 | - | G.H3 | K | 258 | G.H3.16 |
Polar | TM2 | A | 70 | 2x36 | G.H5 | D | 351 | G.H5.22 |
Hydrophobic | TM2 | A | 70 | 2x36 | G.H5 | D | 351 | G.H5.22 |
Polar | ICL3 | S | 284 | - | G.h4s6 | D | 316 | G.h4s6.09 |
Hydrophobic | ICL2 | L | 143 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM6 | Q | 298 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | F | 73 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Van-der-waals | TM2 | F | 73 | 2x39 | G.H5 | C | 352 | G.H5.23 |
Hydrophobic | TM6 | M | 295 | 6x33 | G.H5 | F | 355 | G.H5.26 |
Van-der-waals | TM6 | M | 295 | 6x33 | G.H5 | F | 355 | G.H5.26 |
Hydrophobic | C-term | F | 402 | - | G.S1 | L | 39 | G.S1.07 |
Polar | ICL3 | S | 284 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Hydrophobic | ICL3 | S | 284 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Van-der-waals | ICL3 | S | 284 | - | G.h4s6 | K | 315 | G.h4s6.08 |
Polar | C-term | H | 401 | - | G.s1h1 | G | 42 | G.s1h1.03 |
Hydrophobic | TM3 | V | 139 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 139 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM2 | R | 67 | 2x33 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | TM2 | F | 73 | 2x39 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL2 | P | 142 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Ionic | TM2 | R | 67 | 2x33 | G.h3s5 | D | 262 | G.h3s5.02 |
Polar | TM2 | R | 67 | 2x33 | G.h3s5 | D | 262 | G.h3s5.02 |
Van-der-waals | TM2 | R | 67 | 2x33 | G.h3s5 | D | 262 | G.h3s5.02 |