Gi1 - EP2 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.3

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar TM3 S 137 3x53 G.H5 C 351 G.H5.23
Hydrophobic TM3 S 137 3x53 G.H5 C 351 G.H5.23
Van-der-waals TM3 S 137 3x53 G.H5 C 351 G.H5.23
Polar TM6 H 262 6x33 G.H5 F 354 G.H5.26
Aromatic TM6 H 262 6x33 G.H5 F 354 G.H5.26
Hydrophobic TM6 H 262 6x33 G.H5 F 354 G.H5.26
Van-der-waals TM6 H 262 6x33 G.H5 F 354 G.H5.26
Hydrophobic C-term L 358 - G.H3 I 253 G.H3.12
Polar TM5 S 229 5x70 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 S 229 5x70 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM5 S 229 5x70 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM5 C 234 5x75 G.H4 Q 304 G.H4.12
Hydrophobic H8 P 320 8x48 G.H5 F 354 G.H5.26
Van-der-waals H8 P 320 8x48 G.H5 F 354 G.H5.26
Hydrophobic ICL2 Y 142 34x51 G.S3 L 194 G.S3.01
Van-der-waals ICL2 Y 142 34x51 G.S3 L 194 G.S3.01
Van-der-waals TM5 S 232 5x73 G.H4 E 308 G.H4.16
Polar TM5 C 234 5x75 G.H4 E 308 G.H4.16
Hydrophobic TM5 C 234 5x75 G.H4 E 308 G.H4.16
Van-der-waals TM5 C 234 5x75 G.H4 E 308 G.H4.16
Hydrophobic C-term L 358 - G.h2s4 F 215 G.h2s4.01
Hydrophobic TM6 H 262 6x33 G.H5 L 348 G.H5.20
Van-der-waals TM6 H 262 6x33 G.H5 L 348 G.H5.20
Polar TM2 S 65 2x37 G.H5 D 350 G.H5.22
Hydrophobic TM2 S 65 2x37 G.H5 D 350 G.H5.22
Van-der-waals TM2 S 65 2x37 G.H5 D 350 G.H5.22
Hydrophobic C-term L 358 - G.H3 S 252 G.H3.11
Van-der-waals C-term L 358 - G.H3 S 252 G.H3.11
Polar TM3 E 133 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM3 E 133 3x49 G.H5 C 351 G.H5.23
Van-der-waals TM3 E 133 3x49 G.H5 C 351 G.H5.23
Hydrophobic TM5 M 225 5x66 G.H5 K 345 G.H5.17
Van-der-waals TM5 M 225 5x66 G.H5 K 345 G.H5.17
Ionic TM5 R 233 5x74 G.h4s6 E 318 G.h4s6.12
Polar TM5 R 233 5x74 G.h4s6 E 318 G.h4s6.12
Hydrophobic H8 P 321 8x49 G.H5 F 354 G.H5.26
Van-der-waals H8 P 321 8x49 G.H5 F 354 G.H5.26
Polar TM6 S 255 6x26 G.h4s6 D 315 G.h4s6.09
Hydrophobic TM6 S 255 6x26 G.h4s6 D 315 G.h4s6.09
Van-der-waals TM6 S 255 6x26 G.h4s6 D 315 G.h4s6.09
Ionic C-term D 351 - G.H3 K 257 G.H3.16
Polar C-term D 351 - G.H3 K 257 G.H3.16
Hydrophobic ICL2 Q 145 34x54 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Q 145 34x54 G.H5 I 343 G.H5.15
Hydrophobic ICL2 P 141 34x50 G.H5 I 344 G.H5.16
Hydrophobic TM3 R 134 3x50 G.H5 C 351 G.H5.23
Van-der-waals TM3 R 134 3x50 G.H5 C 351 G.H5.23
Polar TM3 S 137 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 S 137 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 S 137 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM5 L 222 5x63 G.H5 L 348 G.H5.20
Van-der-waals TM5 L 222 5x63 G.H5 L 348 G.H5.20
Hydrophobic ICL2 Y 142 34x51 G.H5 V 339 G.H5.11
Van-der-waals ICL2 Y 142 34x51 G.H5 V 339 G.H5.11
Polar ICL2 Y 142 34x51 G.H5 T 340 G.H5.12
Hydrophobic ICL2 Y 142 34x51 G.H5 T 340 G.H5.12
Van-der-waals ICL2 Y 142 34x51 G.H5 T 340 G.H5.12
Hydrophobic TM3 I 138 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 138 3x54 G.H5 L 348 G.H5.20
Hydrophobic TM6 L 265 6x36 G.H5 L 353 G.H5.25
Ionic TM5 R 228 5x69 G.H5 D 337 G.H5.09
Polar TM5 R 228 5x69 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 228 5x69 G.H5 D 337 G.H5.09
Van-der-waals TM5 R 228 5x69 G.H5 D 337 G.H5.09
Hydrophobic TM5 R 233 5x74 G.H4 E 308 G.H4.16
Van-der-waals TM5 R 233 5x74 G.H4 E 308 G.H4.16
Polar TM5 C 234 5x75 G.H4 A 301 G.H4.08
Hydrophobic TM5 C 234 5x75 G.H4 A 301 G.H4.08
Van-der-waals TM5 C 234 5x75 G.H4 A 301 G.H4.08
Hydrophobic TM5 M 225 5x66 G.H5 I 344 G.H5.16
Van-der-waals TM5 M 225 5x66 G.H5 I 344 G.H5.16
Polar TM5 C 234 5x75 G.H4 C 305 G.H4.13
Hydrophobic TM5 C 234 5x75 G.H4 C 305 G.H4.13
Van-der-waals TM5 C 234 5x75 G.H4 C 305 G.H4.13
Hydrophobic ICL2 Y 142 34x51 G.H5 I 343 G.H5.15
Van-der-waals ICL2 Y 142 34x51 G.H5 I 343 G.H5.15
Hydrophobic TM6 E 258 6x29 G.H5 F 354 G.H5.26
Van-der-waals TM6 E 258 6x29 G.H5 F 354 G.H5.26
Polar ICL2 R 146 34x55 G.s2s3 D 193 G.s2s3.02
Hydrophobic TM2 F 67 2x39 G.H5 C 351 G.H5.23
Van-der-waals TM2 F 67 2x39 G.H5 C 351 G.H5.23
Hydrophobic TM5 M 225 5x66 G.H5 D 341 G.H5.13
Ionic ICL1 R 60 - G.h3s5 D 261 G.h3s5.02
Polar ICL1 R 60 - G.h3s5 D 261 G.h3s5.02
Van-der-waals ICL1 R 60 - G.h3s5 D 261 G.h3s5.02
Polar TM5 S 232 5x73 G.S6 T 321 G.S6.03
Van-der-waals TM5 S 232 5x73 G.S6 T 321 G.S6.03
Hydrophobic TM6 L 266 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM3 I 138 3x54 G.H5 I 344 G.H5.16
Van-der-waals TM3 I 138 3x54 G.H5 I 344 G.H5.16
Hydrophobic H8 P 320 8x48 G.H5 L 353 G.H5.25
Van-der-waals H8 P 320 8x48 G.H5 L 353 G.H5.25
Polar TM5 S 232 5x73 G.H4 Q 304 G.H4.12
Van-der-waals TM5 S 232 5x73 G.H4 Q 304 G.H4.12
Hydrophobic TM3 R 134 3x50 G.H5 L 353 G.H5.25
Van-der-waals TM3 R 134 3x50 G.H5 L 353 G.H5.25
Polar TM6 H 262 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 H 262 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 H 262 6x33 G.H5 L 353 G.H5.25
Polar ICL2 Y 142 34x51 G.H5 F 336 G.H5.08
Aromatic ICL2 Y 142 34x51 G.H5 F 336 G.H5.08
Hydrophobic ICL2 Y 142 34x51 G.H5 F 336 G.H5.08
Van-der-waals ICL2 Y 142 34x51 G.H5 F 336 G.H5.08
Hydrophobic TM5 S 232 5x73 G.S6 Y 320 G.S6.02
Van-der-waals TM5 S 232 5x73 G.S6 Y 320 G.S6.02
Hydrophobic TM3 I 138 3x54 G.H5 N 347 G.H5.19
Polar TM5 S 232 5x73 G.S6 I 319 G.S6.01
Van-der-waals TM5 S 232 5x73 G.S6 I 319 G.S6.01
Ionic TM5 R 228 5x69 G.H5 D 341 G.H5.13
Polar TM5 R 228 5x69 G.H5 D 341 G.H5.13
Hydrophobic TM5 R 228 5x69 G.H5 D 341 G.H5.13
Van-der-waals TM5 R 228 5x69 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 141 34x50 G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 141 34x50 G.H5 I 343 G.H5.15
Hydrophobic TM2 F 67 2x39 G.H5 D 350 G.H5.22
Van-der-waals TM2 F 67 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 Y 144 34x53 G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 141 34x50 G.H5 T 340 G.H5.12
Polar ICL2 R 146 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 R 146 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 R 146 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM2 F 67 2x39 G.H5 G 352 G.H5.24
Van-der-waals TM2 F 67 2x39 G.H5 G 352 G.H5.24