Gi3 -
EP2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | S | 137 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | S | 137 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | S | 137 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | H | 262 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | H | 262 | 6x33 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM5 | S | 229 | 5x70 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | S | 229 | 5x70 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | C | 234 | 5x75 | G.H4 | Q | 304 | G.H4.12 |
Van-der-waals | TM5 | C | 234 | 5x75 | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | Y | 142 | 34x51 | G.S3 | L | 194 | G.S3.01 |
Ionic | TM5 | R | 233 | 5x74 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM5 | R | 233 | 5x74 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | R | 233 | 5x74 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM5 | R | 233 | 5x74 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | M | 269 | 6x40 | G.H5 | L | 353 | G.H5.25 |
Polar | TM6 | E | 258 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | E | 258 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | E | 258 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Ionic | ICL2 | R | 146 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Polar | ICL2 | R | 146 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | R | 146 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | R | 146 | 34x55 | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL1 | R | 60 | - | G.h3s5 | E | 261 | G.h3s5.02 |
Van-der-waals | ICL1 | R | 60 | - | G.h3s5 | E | 261 | G.h3s5.02 |
Hydrophobic | TM5 | S | 232 | 5x73 | G.S6 | T | 321 | G.S6.03 |
Van-der-waals | TM5 | S | 232 | 5x73 | G.S6 | T | 321 | G.S6.03 |
Hydrophobic | TM3 | I | 138 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Polar | TM5 | S | 232 | 5x73 | G.H4 | Q | 304 | G.H4.12 |
Van-der-waals | TM5 | S | 232 | 5x73 | G.H4 | Q | 304 | G.H4.12 |
Hydrophobic | TM3 | R | 134 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL2 | Y | 142 | 34x51 | G.s2s3 | K | 192 | G.s2s3.01 |
Hydrophobic | TM2 | F | 67 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | F | 67 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Polar | ICL2 | R | 146 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | R | 146 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | R | 146 | 34x55 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM6 | E | 258 | 6x29 | G.h4s6 | T | 316 | G.h4s6.10 |
Van-der-waals | TM6 | E | 258 | 6x29 | G.h4s6 | T | 316 | G.h4s6.10 |
Polar | TM6 | H | 262 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | H | 262 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | H | 262 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Polar | TM2 | S | 65 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM2 | S | 65 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | TM2 | S | 65 | 2x37 | G.H5 | E | 350 | G.H5.22 |
Polar | TM3 | E | 133 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | E | 133 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | E | 133 | 3x49 | G.H5 | C | 351 | G.H5.23 |
Polar | TM6 | S | 255 | 6x26 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | S | 255 | 6x26 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.S2 | F | 191 | G.S2.08 |
Van-der-waals | ICL2 | Y | 142 | 34x51 | G.S2 | F | 191 | G.S2.08 |
Polar | ICL2 | Y | 142 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | Y | 142 | 34x51 | G.H5 | T | 340 | G.H5.12 |
Polar | TM4 | S | 151 | 4x40 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | TM4 | S | 151 | 4x40 | G.HN | E | 28 | G.HN.52 |
Polar | TM5 | C | 234 | 5x75 | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | TM5 | C | 234 | 5x75 | G.H4 | C | 305 | G.H4.13 |
Van-der-waals | TM5 | C | 234 | 5x75 | G.H4 | C | 305 | G.H4.13 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Polar | TM4 | S | 149 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | TM4 | S | 149 | 4x38 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | ICL2 | R | 146 | 34x55 | G.S3 | L | 194 | G.S3.01 |
Polar | TM6 | H | 262 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | H | 262 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | H | 262 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | H8 | P | 320 | 8x48 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | M | 225 | 5x66 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | M | 225 | 5x66 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | H8 | P | 321 | 8x49 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | H8 | P | 321 | 8x49 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM5 | R | 233 | 5x74 | G.H4 | Q | 304 | G.H4.12 |
Van-der-waals | TM5 | R | 233 | 5x74 | G.H4 | Q | 304 | G.H4.12 |
Van-der-waals | ICL2 | Q | 145 | 34x54 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM5 | L | 222 | 5x63 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM5 | L | 222 | 5x63 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | Q | 145 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 145 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 145 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM3 | I | 138 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 138 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | L | 265 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM5 | R | 233 | 5x74 | G.H4 | E | 308 | G.H4.16 |
Polar | TM5 | C | 234 | 5x75 | G.H4 | A | 301 | G.H4.08 |
Hydrophobic | TM5 | C | 234 | 5x75 | G.H4 | A | 301 | G.H4.08 |
Van-der-waals | TM5 | C | 234 | 5x75 | G.H4 | A | 301 | G.H4.08 |
Hydrophobic | TM5 | M | 225 | 5x66 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | M | 225 | 5x66 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | Y | 142 | 34x51 | G.S3 | F | 196 | G.S3.03 |
Hydrophobic | ICL2 | Q | 145 | 34x54 | G.S1 | V | 34 | G.S1.02 |
Polar | TM4 | S | 151 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | TM4 | S | 151 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | S | 151 | 4x40 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | Y | 144 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM2 | F | 67 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM2 | F | 67 | 2x39 | G.H5 | G | 352 | G.H5.24 |
Polar | TM5 | C | 234 | 5x75 | G.H4 | E | 308 | G.H4.16 |
Hydrophobic | TM5 | C | 234 | 5x75 | G.H4 | E | 308 | G.H4.16 |
Van-der-waals | TM5 | C | 234 | 5x75 | G.H4 | E | 308 | G.H4.16 |
Ionic | TM6 | E | 258 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Polar | TM6 | E | 258 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM6 | E | 258 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | E | 258 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | ICL2 | P | 141 | 34x50 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM3 | R | 134 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Polar | TM3 | S | 137 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | S | 137 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | S | 137 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | Q | 145 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Van-der-waals | ICL2 | Q | 145 | 34x54 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | Q | 145 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 145 | 34x54 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM2 | F | 67 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | F | 67 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM5 | M | 225 | 5x66 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | H8 | P | 320 | 8x48 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | H8 | P | 320 | 8x48 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | I | 138 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL3 | L | 238 | - | G.H4 | E | 298 | G.H4.05 |
Van-der-waals | ICL3 | L | 238 | - | G.H4 | E | 298 | G.H4.05 |
Ionic | TM5 | R | 228 | 5x69 | G.H5 | D | 341 | G.H5.13 |
Polar | TM5 | R | 228 | 5x69 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | R | 228 | 5x69 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | R | 228 | 5x69 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | P | 141 | 34x50 | G.H5 | T | 340 | G.H5.12 |