G13 -
EP4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.0
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 13.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM5 | M | 213 | 5x68 | G.H5 | H | 368 | G.H5.17 |
Polar | ICL3 | R | 256 | - | G.h4s6 | R | 334 | G.h4s6.08 |
Van-der-waals | ICL3 | R | 256 | - | G.h4s6 | R | 334 | G.h4s6.08 |
Hydrophobic | H8 | R | 333 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | R | 333 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | V | 131 | 34x57 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | V | 131 | 34x57 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | H8 | T | 335 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | H8 | T | 335 | 8x49 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM3 | R | 117 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | L | 367 | G.H5.16 |
Ionic | TM5 | R | 220 | 5x75 | G.H5 | D | 361 | G.H5.10 |
Polar | TM5 | R | 220 | 5x75 | G.H5 | D | 361 | G.H5.10 |
Van-der-waals | TM5 | R | 220 | 5x75 | G.H5 | D | 361 | G.H5.10 |
Ionic | C-term | E | 485 | - | G.HG | K | 306 | G.HG.16 |
Polar | C-term | E | 485 | - | G.HG | K | 306 | G.HG.16 |
Hydrophobic | C-term | E | 485 | - | G.HG | K | 306 | G.HG.16 |
Van-der-waals | C-term | E | 485 | - | G.HG | K | 306 | G.HG.16 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | L | 374 | G.H5.23 |
Polar | C-term | L | 399 | - | H.hbhc | R | 128 | H.hbhc.01 |
Van-der-waals | C-term | L | 399 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Polar | TM3 | A | 120 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | A | 120 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM6 | E | 267 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Polar | C-term | S | 390 | - | G.s4h3 | D | 259 | G.s4h3.11 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | C | 487 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Van-der-waals | C-term | C | 487 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | I | 121 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | C-term | Q | 393 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | F | 54 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM1 | L | 42 | 1x57 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM2 | Y | 55 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM5 | R | 220 | 5x75 | G.S6 | H | 344 | G.S6.03 |
Aromatic | TM5 | F | 217 | 5x72 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM5 | F | 217 | 5x72 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | C-term | I | 488 | - | G.H4 | F | 325 | G.H4.10 |
Van-der-waals | C-term | I | 488 | - | G.H4 | F | 325 | G.H4.10 |
Polar | ICL2 | Y | 125 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Aromatic | ICL2 | Y | 125 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM5 | M | 213 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | C-term | R | 378 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | R | 378 | - | G.H3 | R | 279 | G.H3.16 |
Polar | ICL2 | H | 129 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Aromatic | ICL2 | H | 129 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | H | 129 | 34x55 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | I | 263 | 6x26 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | ICL3 | F | 260 | - | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | TM5 | R | 220 | 5x75 | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | TM5 | R | 220 | 5x75 | G.H5 | R | 360 | G.H5.09 |
Polar | ICL3 | S | 259 | - | G.h4s6 | Q | 338 | G.h4s6.12 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | TM6 | A | 266 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | A | 266 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | K | 486 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | C-term | K | 486 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Van-der-waals | C-term | K | 486 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | ICL2 | H | 129 | 34x55 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.h4s6 | K | 340 | G.h4s6.19 |
Polar | C-term | I | 488 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | C-term | I | 488 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Van-der-waals | C-term | I | 488 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Ionic | ICL3 | R | 255 | - | G.h4s6 | D | 336 | G.h4s6.10 |
Polar | ICL3 | R | 255 | - | G.h4s6 | D | 336 | G.h4s6.10 |
Hydrophobic | ICL3 | R | 255 | - | G.h4s6 | D | 336 | G.h4s6.10 |
Van-der-waals | ICL3 | R | 255 | - | G.h4s6 | D | 336 | G.h4s6.10 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Ionic | TM6 | E | 267 | 6x30 | G.H5 | H | 368 | G.H5.17 |
Polar | ICL2 | Y | 125 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | K | 363 | G.H5.12 |
Polar | ICL2 | S | 128 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | S | 128 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Polar | C-term | S | 390 | - | G.s4h3 | T | 262 | G.s4h3.14 |
Polar | C-term | S | 392 | - | G.s4h3 | D | 259 | G.s4h3.11 |
Hydrophobic | C-term | S | 392 | - | G.s4h3 | D | 259 | G.s4h3.11 |
Van-der-waals | C-term | S | 392 | - | G.s4h3 | D | 259 | G.s4h3.11 |
Polar | ICL3 | S | 222 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | S | 222 | - | G.H4 | R | 331 | G.H4.16 |
Polar | H8 | R | 333 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | H8 | R | 333 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | H8 | R | 333 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | I | 488 | - | G.H4 | C | 329 | G.H4.14 |
Polar | C-term | T | 394 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Hydrophobic | C-term | T | 394 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Van-der-waals | C-term | T | 394 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Hydrophobic | TM5 | F | 217 | 5x72 | G.h4s6 | P | 341 | G.h4s6.20 |
Polar | C-term | K | 486 | - | G.hgh4 | L | 310 | G.hgh4.03 |
Hydrophobic | C-term | K | 486 | - | G.hgh4 | L | 310 | G.hgh4.03 |
Van-der-waals | C-term | K | 486 | - | G.hgh4 | L | 310 | G.hgh4.03 |
Polar | ICL1 | Q | 49 | - | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL1 | Q | 49 | - | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | ICL1 | Q | 49 | - | G.H5 | Q | 377 | G.H5.26 |
Polar | H8 | T | 335 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL1 | Q | 49 | - | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL1 | Q | 49 | - | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | ICL1 | Q | 49 | - | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | Y | 127 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM6 | Q | 269 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Polar | ICL3 | R | 256 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | ICL3 | R | 256 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | R | 256 | - | G.H4 | R | 331 | G.H4.16 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM6 | I | 263 | 6x26 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | C-term | I | 488 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Van-der-waals | C-term | I | 488 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | E | 485 | - | G.hgh4 | E | 313 | G.hgh4.06 |
Polar | C-term | S | 392 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Van-der-waals | C-term | S | 392 | - | G.s4h3 | E | 258 | G.s4h3.10 |
Hydrophobic | TM6 | A | 266 | 6x29 | G.H5 | L | 371 | G.H5.20 |
Polar | H8 | R | 333 | 8x47 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | H8 | R | 333 | 8x47 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | I | 488 | - | G.hgh4 | F | 312 | G.hgh4.05 |
Hydrophobic | TM3 | E | 116 | 3x49 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | L | 401 | - | H.hbhc | R | 128 | H.hbhc.01 |
Van-der-waals | C-term | L | 401 | - | H.hbhc | R | 128 | H.hbhc.01 |
Hydrophobic | TM5 | L | 210 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | L | 210 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | TM2 | T | 52 | 2x37 | G.H5 | Q | 373 | G.H5.22 |
Polar | ICL3 | R | 256 | - | G.H4 | N | 332 | G.H4.17 |
Hydrophobic | ICL3 | R | 256 | - | G.H4 | N | 332 | G.H4.17 |
Van-der-waals | ICL3 | R | 256 | - | G.H4 | N | 332 | G.H4.17 |
Polar | C-term | H | 376 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | E | 485 | - | G.hgh4 | F | 312 | G.hgh4.05 |
Polar | C-term | C | 487 | - | G.hgh4 | E | 313 | G.hgh4.06 |
Hydrophobic | C-term | C | 487 | - | G.hgh4 | E | 313 | G.hgh4.06 |
Van-der-waals | C-term | C | 487 | - | G.hgh4 | E | 313 | G.hgh4.06 |
Ionic | ICL3 | E | 226 | - | G.H4 | R | 331 | G.H4.16 |
Polar | ICL3 | E | 226 | - | G.H4 | R | 331 | G.H4.16 |
Van-der-waals | ICL3 | E | 226 | - | G.H4 | R | 331 | G.H4.16 |
Ionic | TM5 | R | 220 | 5x75 | G.H5 | D | 364 | G.H5.13 |
Polar | TM5 | R | 220 | 5x75 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM5 | R | 220 | 5x75 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | R | 220 | 5x75 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | TM4 | D | 132 | 4x38 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S1 | V | 49 | G.S1.02 |