Gq -
EP4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 11.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Polar | TM3 | E | 116 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | E | 116 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | E | 116 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL3 | D | 253 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | ICL3 | D | 253 | - | G.H4 | K | 311 | G.H4.13 |
Polar | ICL1 | Q | 49 | - | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL1 | Q | 49 | - | G.H5 | L | 358 | G.H5.25 |
Polar | H8 | T | 335 | 8x49 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | H8 | T | 335 | 8x49 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | H8 | T | 335 | 8x49 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | M | 213 | 5x68 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | I | 488 | - | H.HE | Y | 159 | H.HE.04 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S3 | F | 201 | G.S3.03 |
Hydrophobic | ICL2 | Y | 127 | 34x53 | G.H5 | N | 352 | G.H5.19 |
Ionic | TM5 | R | 220 | 5x75 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | H8 | R | 333 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | H8 | R | 333 | 8x47 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | I | 263 | 6x26 | G.H5 | Q | 350 | G.H5.17 |
Polar | ICL3 | Q | 227 | - | G.H4 | K | 311 | G.H4.13 |
Van-der-waals | ICL3 | Q | 227 | - | G.H4 | K | 311 | G.H4.13 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM6 | M | 270 | 6x33 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | S | 377 | - | G.H3 | P | 262 | G.H3.16 |
Van-der-waals | C-term | S | 377 | - | G.H3 | P | 262 | G.H3.16 |
Polar | C-term | I | 488 | - | H.HF | R | 181 | H.HF.06 |
Hydrophobic | C-term | I | 488 | - | H.HF | R | 181 | H.HF.06 |
Van-der-waals | C-term | I | 488 | - | H.HF | R | 181 | H.HF.06 |
Hydrophobic | H8 | R | 333 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | I | 488 | - | G.s6h5 | C | 330 | G.s6h5.02 |
Hydrophobic | C-term | I | 488 | - | G.s6h5 | C | 330 | G.s6h5.02 |
Van-der-waals | C-term | I | 488 | - | G.s6h5 | C | 330 | G.s6h5.02 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 120 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | I | 121 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Polar | TM6 | A | 266 | 6x29 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM5 | M | 213 | 5x68 | G.H5 | Q | 350 | G.H5.17 |
Polar | ICL2 | H | 129 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL2 | H | 129 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Van-der-waals | ICL2 | H | 129 | 34x55 | G.hns1 | R | 38 | G.hns1.03 |
Hydrophobic | ICL3 | R | 256 | - | G.H4 | V | 314 | G.H4.16 |
Van-der-waals | ICL3 | R | 256 | - | G.H4 | V | 314 | G.H4.16 |
Polar | TM6 | Q | 269 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM6 | Q | 269 | 6x32 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | I | 488 | - | G.HG | D | 277 | G.HG.02 |
Polar | TM3 | R | 117 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 117 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 117 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Polar | H8 | T | 335 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | T | 335 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Polar | C-term | I | 488 | - | G.s6h5 | T | 332 | G.s6h5.04 |
Polar | TM3 | A | 120 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 120 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S3 | V | 199 | G.S3.01 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Polar | ICL2 | H | 129 | 34x55 | G.s2s3 | S | 198 | G.s2s3.02 |
Van-der-waals | ICL2 | H | 129 | 34x55 | G.s2s3 | S | 198 | G.s2s3.02 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | M | 213 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Polar | ICL3 | S | 259 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | ICL3 | S | 259 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | ICL3 | S | 259 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Polar | ICL2 | Y | 125 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | H8 | T | 335 | 8x49 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | T | 335 | 8x49 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM5 | L | 210 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM5 | L | 210 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Aromatic | ICL2 | Y | 130 | 34x56 | G.hns1 | R | 38 | G.hns1.03 |
Ionic | ICL3 | D | 253 | - | G.H4 | D | 315 | G.H4.17 |
Polar | ICL3 | D | 253 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | TM6 | E | 267 | 6x30 | G.H5 | L | 353 | G.H5.20 |
Polar | H8 | R | 333 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | H8 | R | 333 | 8x47 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | ICL1 | Q | 49 | - | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | ICL1 | Q | 49 | - | G.H5 | V | 359 | G.H5.26 |
Polar | TM2 | T | 52 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | T | 52 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | T | 52 | 2x37 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | V | 344 | G.H5.11 |
Ionic | TM4 | D | 132 | 4x38 | G.HN | R | 34 | G.HN.52 |
Polar | TM4 | D | 132 | 4x38 | G.HN | R | 34 | G.HN.52 |
Van-der-waals | TM4 | D | 132 | 4x38 | G.HN | R | 34 | G.HN.52 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM6 | M | 270 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Aromatic | TM2 | F | 54 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | F | 54 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | I | 381 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | I | 381 | - | G.H3 | Y | 261 | G.H3.15 |
Ionic | TM6 | R | 262 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM6 | R | 262 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM6 | R | 262 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | TM6 | R | 262 | 6x25 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | C-term | I | 488 | - | H.HF | Q | 177 | H.HF.02 |
Polar | ICL2 | Y | 125 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Aromatic | ICL2 | Y | 125 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | F | 341 | G.H5.08 |