Gs -
EP4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | V | 474 | - | G.H1 | H | 64 | G.H1.12 |
Van-der-waals | C-term | V | 474 | - | G.H1 | H | 64 | G.H1.12 |
Polar | ICL3 | S | 222 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Hydrophobic | ICL3 | S | 222 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Van-der-waals | ICL3 | S | 222 | - | G.hgh4 | D | 323 | G.hgh4.13 |
Ionic | TM6 | E | 267 | 6x30 | G.H5 | R | 385 | G.H5.17 |
Polar | TM6 | E | 267 | 6x30 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM6 | E | 267 | 6x30 | G.H5 | R | 385 | G.H5.17 |
Van-der-waals | TM6 | E | 267 | 6x30 | G.H5 | R | 385 | G.H5.17 |
Ionic | TM4 | D | 132 | 4x38 | G.hns1 | R | 38 | G.hns1.02 |
Polar | TM4 | D | 132 | 4x38 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | TM4 | D | 132 | 4x38 | G.hns1 | R | 38 | G.hns1.02 |
Van-der-waals | TM4 | D | 132 | 4x38 | G.hns1 | R | 38 | G.hns1.02 |
Hydrophobic | C-term | L | 472 | - | G.H5 | R | 373 | G.H5.05 |
Van-der-waals | C-term | L | 472 | - | G.H5 | R | 373 | G.H5.05 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | Y | 391 | G.H5.23 |
Polar | C-term | Q | 473 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Hydrophobic | C-term | Q | 473 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | C-term | Q | 473 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | ICL2 | S | 128 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | S | 128 | 34x54 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | C-term | P | 477 | - | G.S2 | Q | 213 | G.S2.07 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | ICL2 | A | 124 | 34x50 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | ICL3 | R | 256 | - | G.H4 | R | 347 | G.H4.17 |
Van-der-waals | ICL3 | R | 256 | - | G.H4 | R | 347 | G.H4.17 |
Van-der-waals | ICL1 | Q | 49 | - | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | C | 379 | G.H5.11 |
Hydrophobic | H8 | T | 335 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | H8 | T | 335 | 8x49 | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | C-term | L | 396 | - | G.H3 | L | 272 | G.H3.08 |
Van-der-waals | C-term | L | 396 | - | G.H3 | L | 272 | G.H3.08 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM6 | I | 263 | 6x26 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | R | 380 | G.H5.12 |
Polar | C-term | T | 475 | - | G.S2 | Q | 213 | G.S2.07 |
Hydrophobic | C-term | T | 475 | - | G.S2 | Q | 213 | G.S2.07 |
Van-der-waals | C-term | T | 475 | - | G.S2 | Q | 213 | G.S2.07 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | I | 383 | G.H5.15 |
Polar | ICL2 | Y | 125 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Aromatic | ICL2 | Y | 125 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | F | 376 | G.H5.08 |
Hydrophobic | ICL3 | T | 225 | - | G.hgh4 | R | 317 | G.hgh4.07 |
Van-der-waals | ICL3 | T | 225 | - | G.hgh4 | R | 317 | G.hgh4.07 |
Polar | C-term | T | 394 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | C-term | T | 394 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | T | 394 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | ICL3 | L | 223 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Hydrophobic | ICL3 | G | 224 | - | G.hgh4 | T | 320 | G.hgh4.10 |
Hydrophobic | C-term | L | 395 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | TM6 | M | 270 | 6x33 | G.H5 | L | 388 | G.H5.20 |
Polar | ICL2 | Y | 127 | 34x53 | G.H5 | Q | 390 | G.H5.22 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | I | 383 | G.H5.15 |
Polar | TM3 | E | 116 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | E | 116 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | E | 116 | 3x49 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | F | 476 | - | G.S2 | F | 212 | G.S2.06 |
Van-der-waals | C-term | F | 476 | - | G.S2 | F | 212 | G.S2.06 |
Polar | TM3 | A | 120 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | TM3 | A | 120 | 3x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | H8 | V | 336 | 8x50 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | C-term | Q | 393 | - | G.s4h3 | R | 258 | G.s4h3.09 |
Van-der-waals | C-term | Q | 393 | - | G.s4h3 | R | 258 | G.s4h3.09 |
Polar | H8 | R | 333 | 8x47 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | H8 | R | 333 | 8x47 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | H8 | R | 333 | 8x47 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | L | 472 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Van-der-waals | C-term | L | 472 | - | G.s2s3 | D | 215 | G.s2s3.01 |
Polar | TM1 | S | 45 | 1x60 | G.H5 | L | 393 | G.H5.25 |
Van-der-waals | TM1 | S | 45 | 1x60 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | V | 474 | - | G.S2 | Q | 213 | G.S2.07 |
Van-der-waals | C-term | V | 474 | - | G.S2 | Q | 213 | G.S2.07 |
Aromatic | ICL2 | Y | 125 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S1 | H | 41 | G.S1.02 |
Polar | ICL2 | Y | 125 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.H5 | R | 380 | G.H5.12 |
Hydrophobic | TM5 | L | 210 | 5x65 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | ICL3 | G | 224 | - | G.hgh4 | Y | 318 | G.hgh4.08 |
Hydrophobic | TM1 | L | 42 | 1x57 | G.H5 | L | 393 | G.H5.25 |
Aromatic | ICL2 | Y | 127 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL2 | Y | 127 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Van-der-waals | ICL2 | Y | 127 | 34x53 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | ICL3 | G | 224 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Van-der-waals | ICL3 | G | 224 | - | G.hgh4 | P | 321 | G.hgh4.11 |
Hydrophobic | TM5 | R | 220 | 5x75 | G.S6 | Y | 360 | G.S6.02 |
Van-der-waals | TM5 | R | 220 | 5x75 | G.S6 | Y | 360 | G.S6.02 |
Hydrophobic | TM5 | F | 217 | 5x72 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | C-term | L | 395 | - | G.s4h3 | I | 257 | G.s4h3.08 |
Van-der-waals | C-term | L | 395 | - | G.s4h3 | I | 257 | G.s4h3.08 |
Hydrophobic | ICL2 | A | 124 | 34x50 | G.H5 | H | 387 | G.H5.19 |
Hydrophobic | TM2 | Y | 55 | 2x40 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.h4s6 | G | 355 | G.h4s6.11 |
Hydrophobic | ICL3 | T | 225 | - | G.hgh4 | Y | 318 | G.hgh4.08 |
Van-der-waals | ICL3 | T | 225 | - | G.hgh4 | Y | 318 | G.hgh4.08 |
Hydrophobic | C-term | T | 480 | - | G.h1ha | G | 73 | G.h1ha.09 |
Van-der-waals | C-term | T | 480 | - | G.h1ha | G | 73 | G.h1ha.09 |
Hydrophobic | ICL3 | L | 223 | - | G.H4 | L | 346 | G.H4.16 |
Hydrophobic | ICL3 | F | 260 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Van-der-waals | ICL3 | F | 260 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | C-term | L | 472 | - | G.S2 | V | 214 | G.S2.08 |
Van-der-waals | C-term | L | 472 | - | G.S2 | V | 214 | G.S2.08 |
Hydrophobic | TM6 | I | 263 | 6x26 | G.h4s6 | G | 353 | G.h4s6.09 |
Polar | ICL3 | S | 259 | - | G.h4s6 | T | 350 | G.h4s6.03 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | C-term | Q | 393 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | Q | 393 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Polar | ICL1 | Q | 49 | - | G.H5 | E | 392 | G.H5.24 |
Hydrophobic | ICL1 | Q | 49 | - | G.H5 | E | 392 | G.H5.24 |
Van-der-waals | ICL1 | Q | 49 | - | G.H5 | E | 392 | G.H5.24 |
Polar | C-term | L | 396 | - | G.H3 | E | 268 | G.H3.04 |
Hydrophobic | C-term | L | 396 | - | G.H3 | E | 268 | G.H3.04 |
Van-der-waals | C-term | L | 396 | - | G.H3 | E | 268 | G.H3.04 |
Hydrophobic | TM2 | V | 58 | 2x43 | G.H5 | L | 393 | G.H5.25 |
Polar | TM5 | R | 220 | 5x75 | G.H4 | R | 342 | G.H4.12 |
Polar | C-term | S | 392 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | C-term | S | 392 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Van-der-waals | C-term | S | 392 | - | G.s4h3 | E | 259 | G.s4h3.10 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S3 | F | 219 | G.S3.03 |
Polar | C-term | Q | 473 | - | G.s2s3 | K | 216 | G.s2s3.02 |
Hydrophobic | C-term | L | 396 | - | G.H3 | N | 271 | G.H3.07 |
Van-der-waals | C-term | L | 396 | - | G.H3 | N | 271 | G.H3.07 |
Hydrophobic | C-term | F | 476 | - | G.h1ha | V | 65 | G.h1ha.01 |
Van-der-waals | C-term | F | 476 | - | G.h1ha | V | 65 | G.h1ha.01 |
Hydrophobic | TM6 | E | 267 | 6x30 | G.H5 | L | 388 | G.H5.20 |
Hydrophobic | C-term | L | 395 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Van-der-waals | C-term | L | 395 | - | G.s4h3 | D | 260 | G.s4h3.11 |
Hydrophobic | TM5 | F | 217 | 5x72 | G.h4s6 | Y | 358 | G.h4s6.20 |
Van-der-waals | TM5 | F | 217 | 5x72 | G.h4s6 | Y | 358 | G.h4s6.20 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | T | 394 | - | G.H3 | E | 268 | G.H3.04 |
Van-der-waals | ICL3 | G | 224 | - | G.hgh4 | T | 319 | G.hgh4.09 |
Aromatic | TM2 | F | 54 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM2 | F | 54 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM2 | F | 54 | 2x39 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | ICL1 | Q | 49 | - | G.H5 | L | 393 | G.H5.25 |
Hydrophobic | C-term | V | 474 | - | G.S2 | V | 214 | G.S2.08 |
Hydrophobic | ICL3 | L | 223 | - | G.H4 | D | 343 | G.H4.13 |
Van-der-waals | ICL3 | L | 223 | - | G.H4 | D | 343 | G.H4.13 |
Polar | TM5 | M | 213 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | R | 385 | G.H5.17 |
Hydrophobic | TM5 | R | 219 | 5x74 | G.hgh4 | T | 325 | G.hgh4.15 |
Van-der-waals | TM5 | R | 219 | 5x74 | G.hgh4 | T | 325 | G.hgh4.15 |
Hydrophobic | ICL2 | H | 129 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Van-der-waals | ICL2 | H | 129 | 34x55 | G.hns1 | A | 39 | G.hns1.03 |
Polar | ICL3 | G | 224 | - | G.H4 | D | 343 | G.H4.13 |
Van-der-waals | ICL3 | G | 224 | - | G.H4 | D | 343 | G.H4.13 |
Polar | ICL3 | S | 222 | - | G.H4 | R | 342 | G.H4.12 |
Van-der-waals | ICL3 | S | 222 | - | G.H4 | R | 342 | G.H4.12 |
Polar | ICL1 | Q | 49 | - | G.H5 | R | 389 | G.H5.21 |
Hydrophobic | C-term | T | 394 | - | G.s4h3 | I | 257 | G.s4h3.08 |
Van-der-waals | C-term | T | 394 | - | G.s4h3 | I | 257 | G.s4h3.08 |
Ionic | TM5 | R | 220 | 5x75 | G.H5 | D | 378 | G.H5.10 |
Polar | TM5 | R | 220 | 5x75 | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | TM5 | R | 220 | 5x75 | G.H5 | D | 378 | G.H5.10 |
Van-der-waals | TM5 | R | 220 | 5x75 | G.H5 | D | 378 | G.H5.10 |
Hydrophobic | TM7 | I | 330 | 7x54 | G.H5 | L | 393 | G.H5.25 |
Polar | TM3 | I | 121 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM3 | I | 121 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM3 | I | 121 | 3x54 | G.H5 | Q | 384 | G.H5.16 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Van-der-waals | TM5 | M | 213 | 5x68 | G.H5 | D | 381 | G.H5.13 |
Hydrophobic | C-term | F | 476 | - | G.H1 | H | 64 | G.H1.12 |
Van-der-waals | C-term | F | 476 | - | G.H1 | H | 64 | G.H1.12 |
Hydrophobic | C-term | F | 476 | - | G.S2 | K | 211 | G.S2.05 |
Van-der-waals | C-term | F | 476 | - | G.S2 | K | 211 | G.S2.05 |
Polar | TM3 | R | 117 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM3 | R | 117 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | R | 117 | 3x50 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | C-term | L | 472 | - | G.H5 | F | 376 | G.H5.08 |
Polar | H8 | K | 339 | 8x53 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | H8 | K | 339 | 8x53 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | K | 339 | 8x53 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | ICL2 | Y | 125 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Van-der-waals | ICL2 | Y | 125 | 34x51 | G.S3 | V | 217 | G.S3.01 |
Polar | H8 | T | 335 | 8x49 | G.H5 | L | 394 | G.H5.26 |
Van-der-waals | H8 | T | 335 | 8x49 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM5 | M | 213 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Van-der-waals | TM5 | M | 213 | 5x68 | G.H5 | Q | 384 | G.H5.16 |
Polar | ICL3 | T | 225 | - | G.hgh4 | T | 319 | G.hgh4.09 |
Hydrophobic | TM3 | A | 120 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Van-der-waals | TM3 | A | 120 | 3x53 | G.H5 | Y | 391 | G.H5.23 |
Hydrophobic | TM1 | V | 41 | 1x56 | G.H5 | L | 394 | G.H5.26 |
Hydrophobic | TM2 | T | 52 | 2x37 | G.H5 | Q | 390 | G.H5.22 |