Gi2 - FP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.6

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.5


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 F 66 2x39 G.H5 G 353 G.H5.24
Van-der-waals TM2 F 66 2x39 G.H5 G 353 G.H5.24
Hydrophobic ICL2 S 144 34x54 G.H5 I 344 G.H5.15
Van-der-waals ICL3 R 238 - G.S6 I 320 G.S6.01
Polar ICL3 Q 239 - G.H4 E 309 G.H4.16
Hydrophobic ICL3 Q 239 - G.H4 E 309 G.H4.16
Van-der-waals ICL3 Q 239 - G.H4 E 309 G.H4.16
Aromatic TM6 H 243 6x29 G.H5 F 355 G.H5.26
Hydrophobic TM6 H 243 6x29 G.H5 F 355 G.H5.26
Van-der-waals TM6 H 243 6x29 G.H5 F 355 G.H5.26
Polar ICL3 R 238 - G.S6 Y 321 G.S6.02
Hydrophobic ICL3 R 238 - G.S6 Y 321 G.S6.02
Van-der-waals ICL3 R 238 - G.S6 Y 321 G.S6.02
Hydrophobic TM3 V 137 3x54 G.H5 L 349 G.H5.20
Van-der-waals TM3 V 137 3x54 G.H5 L 349 G.H5.20
Van-der-waals ICL3 Q 239 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 G 240 - G.h4s6 K 315 G.h4s6.08
Polar TM6 R 241 6x27 G.h4s6 K 315 G.h4s6.08
Polar C-term N 340 - G.h3s5 T 261 G.h3s5.01
Hydrophobic C-term N 340 - G.h3s5 T 261 G.h3s5.01
Van-der-waals C-term N 340 - G.h3s5 T 261 G.h3s5.01
Hydrophobic C-term I 347 - G.H3 K 258 G.H3.16
Hydrophobic ICL2 I 141 34x51 G.s2s3 D 194 G.s2s3.02
Polar C-term N 340 - G.h3s5 D 262 G.h3s5.02
Van-der-waals C-term N 340 - G.h3s5 D 262 G.h3s5.02
Polar ICL3 Q 239 - G.h4s6 N 312 G.h4s6.02
Van-der-waals ICL3 Q 239 - G.h4s6 N 312 G.h4s6.02
Van-der-waals ICL3 H 237 - G.S6 Y 321 G.S6.02
Polar TM2 F 66 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM2 F 66 2x39 G.H5 D 351 G.H5.22
Van-der-waals TM2 F 66 2x39 G.H5 D 351 G.H5.22
Hydrophobic TM3 R 133 3x50 G.H5 L 354 G.H5.25
Van-der-waals TM3 R 133 3x50 G.H5 L 354 G.H5.25
Polar TM6 Q 250 6x36 G.H5 G 353 G.H5.24
Hydrophobic ICL2 H 143 34x53 G.H5 C 352 G.H5.23
Hydrophobic ICL2 T 145 34x55 G.S3 L 195 G.S3.01
Hydrophobic TM6 M 247 6x33 G.H5 L 349 G.H5.20
Van-der-waals TM6 M 247 6x33 G.H5 L 349 G.H5.20
Hydrophobic ICL3 Q 239 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 Q 239 - G.h4s6 K 315 G.h4s6.08
Polar ICL2 T 145 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 T 145 34x55 G.hns1 R 32 G.hns1.03
Van-der-waals ICL2 T 145 34x55 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 M 247 6x33 G.H5 F 355 G.H5.26
Hydrophobic C-term S 336 - G.h4s6 T 317 G.h4s6.10
Van-der-waals C-term S 336 - G.h4s6 T 317 G.h4s6.10
Polar ICL3 H 237 - G.S6 T 322 G.S6.03
Van-der-waals ICL3 H 237 - G.S6 T 322 G.S6.03
Hydrophobic ICL1 K 63 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL1 K 63 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 R 133 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 C 352 G.H5.23
Polar TM3 G 136 3x53 G.H5 N 348 G.H5.19
Hydrophobic TM3 G 136 3x53 G.H5 N 348 G.H5.19
Van-der-waals TM3 G 136 3x53 G.H5 N 348 G.H5.19
Polar ICL2 H 143 34x53 G.H5 N 348 G.H5.19
Hydrophobic ICL2 H 143 34x53 G.H5 N 348 G.H5.19
Van-der-waals ICL2 H 143 34x53 G.H5 N 348 G.H5.19
Hydrophobic TM2 F 66 2x39 G.H5 C 352 G.H5.23
Van-der-waals TM2 F 66 2x39 G.H5 C 352 G.H5.23
Hydrophobic ICL2 I 141 34x51 G.H5 F 337 G.H5.08
Van-der-waals ICL2 I 141 34x51 G.H5 F 337 G.H5.08
Hydrophobic TM3 E 132 3x49 G.H5 C 352 G.H5.23
Hydrophobic ICL2 P 140 34x50 G.H5 I 344 G.H5.15
Hydrophobic TM5 L 227 5x63 G.H5 L 349 G.H5.20
Van-der-waals TM5 L 227 5x63 G.H5 L 349 G.H5.20
Ionic ICL3 R 238 - G.h4s6 E 319 G.h4s6.12
Polar ICL3 R 238 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 R 238 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 R 238 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL3 G 240 - G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 L 251 6x37 G.H5 L 354 G.H5.25
Polar ICL1 K 63 - G.HN E 28 G.HN.52
Hydrophobic ICL1 K 63 - G.HN E 28 G.HN.52
Polar H8 R 308 8x47 G.H5 G 353 G.H5.24
Hydrophobic H8 R 308 8x47 G.H5 G 353 G.H5.24
Van-der-waals H8 R 308 8x47 G.H5 G 353 G.H5.24
Polar ICL2 P 140 34x50 G.H5 N 348 G.H5.19
Van-der-waals ICL2 P 140 34x50 G.H5 N 348 G.H5.19
Ionic ICL3 R 238 - G.H5 D 342 G.H5.13
Polar ICL3 R 238 - G.H5 D 342 G.H5.13
Van-der-waals ICL3 R 238 - G.H5 D 342 G.H5.13
Hydrophobic TM4 T 148 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 T 148 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic TM6 Q 250 6x36 G.H5 L 354 G.H5.25
Van-der-waals TM6 Q 250 6x36 G.H5 L 354 G.H5.25
Polar ICL3 Q 239 - G.S6 I 320 G.S6.01
Van-der-waals ICL3 Q 239 - G.S6 I 320 G.S6.01
Hydrophobic C-term L 335 - G.h4s6 D 316 G.h4s6.09
Hydrophobic TM6 M 247 6x33 G.H5 L 354 G.H5.25
Van-der-waals TM6 M 247 6x33 G.H5 L 354 G.H5.25
Hydrophobic ICL2 P 140 34x50 G.H5 T 341 G.H5.12
Hydrophobic TM6 R 241 6x27 G.h4s6 D 316 G.h4s6.09
Hydrophobic ICL2 I 141 34x51 G.S3 L 195 G.S3.01
Hydrophobic ICL2 P 140 34x50 G.H5 I 345 G.H5.16
Van-der-waals ICL2 P 140 34x50 G.H5 I 345 G.H5.16