Gs - FP receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gs

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 86.4

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.8
PAE mean: 12.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic ICL3 Q 239 - G.h4s6 T 350 G.h4s6.03
Van-der-waals ICL3 Q 239 - G.h4s6 T 350 G.h4s6.03
Hydrophobic TM5 L 227 5x63 G.H5 L 388 G.H5.20
Polar TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Aromatic TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Hydrophobic TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Van-der-waals TM3 R 133 3x50 G.H5 Y 391 G.H5.23
Polar TM3 V 137 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM3 V 137 3x54 G.H5 Q 384 G.H5.16
Van-der-waals TM3 V 137 3x54 G.H5 Q 384 G.H5.16
Hydrophobic TM2 L 67 2x40 G.H5 L 393 G.H5.25
Van-der-waals TM2 L 67 2x40 G.H5 L 393 G.H5.25
Hydrophobic TM2 A 64 2x37 G.H5 Q 390 G.H5.22
Polar ICL3 Q 236 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL3 Q 236 - G.hgh4 T 325 G.hgh4.15
Van-der-waals ICL3 Q 236 - G.hgh4 T 325 G.hgh4.15
Hydrophobic ICL2 I 141 34x51 G.H5 I 383 G.H5.15
Polar TM3 E 132 3x49 G.H5 Y 391 G.H5.23
Van-der-waals TM3 E 132 3x49 G.H5 Y 391 G.H5.23
Hydrophobic TM6 M 247 6x33 G.H5 Y 391 G.H5.23
Van-der-waals TM6 M 247 6x33 G.H5 Y 391 G.H5.23
Hydrophobic H8 R 308 8x47 G.H5 L 393 G.H5.25
Ionic ICL3 R 238 - G.H5 D 378 G.H5.10
Polar ICL3 R 238 - G.H5 D 378 G.H5.10
Van-der-waals ICL3 R 238 - G.H5 D 378 G.H5.10
Ionic TM3 E 132 3x49 G.H5 H 387 G.H5.19
Hydrophobic TM3 E 132 3x49 G.H5 H 387 G.H5.19
Van-der-waals TM3 E 132 3x49 G.H5 H 387 G.H5.19
Hydrophobic TM6 H 244 6x30 G.H5 L 388 G.H5.20
Van-der-waals TM6 H 244 6x30 G.H5 L 388 G.H5.20
Hydrophobic ICL2 I 141 34x51 G.H5 R 380 G.H5.12
Hydrophobic TM1 F 58 1x64 G.H5 E 392 G.H5.24
Van-der-waals TM1 F 58 1x64 G.H5 E 392 G.H5.24
Polar H8 R 308 8x47 G.H5 Y 391 G.H5.23
Hydrophobic H8 R 308 8x47 G.H5 Y 391 G.H5.23
Van-der-waals H8 R 308 8x47 G.H5 Y 391 G.H5.23
Hydrophobic ICL2 I 141 34x51 G.S3 V 217 G.S3.01
Van-der-waals ICL2 I 141 34x51 G.S3 V 217 G.S3.01
Hydrophobic ICL2 S 144 34x54 G.H5 I 383 G.H5.15
Hydrophobic ICL3 R 238 - G.S6 Y 360 G.S6.02
Van-der-waals ICL3 R 238 - G.S6 Y 360 G.S6.02
Hydrophobic TM3 V 137 3x54 G.H5 H 387 G.H5.19
Van-der-waals TM4 T 148 4x38 G.hns1 R 38 G.hns1.02
Hydrophobic ICL2 I 141 34x51 G.H5 F 376 G.H5.08
Ionic TM6 R 241 6x27 G.H5 D 381 G.H5.13
Polar TM6 R 241 6x27 G.H5 D 381 G.H5.13
Van-der-waals TM6 R 241 6x27 G.H5 D 381 G.H5.13
Polar ICL3 H 237 - G.H4 R 342 G.H4.12
Aromatic ICL3 H 237 - G.H4 R 342 G.H4.12
Hydrophobic ICL3 H 237 - G.H4 R 342 G.H4.12
Van-der-waals ICL3 H 237 - G.H4 R 342 G.H4.12
Hydrophobic TM1 F 58 1x64 G.H5 L 393 G.H5.25
Hydrophobic TM3 G 136 3x53 G.H5 H 387 G.H5.19
Van-der-waals TM3 G 136 3x53 G.H5 H 387 G.H5.19
Hydrophobic H8 A 310 8x49 G.H5 L 394 G.H5.26
Hydrophobic ICL3 G 240 - G.h4s6 Y 358 G.h4s6.20
Hydrophobic TM6 R 241 6x27 G.H5 R 385 G.H5.17
Van-der-waals TM6 R 241 6x27 G.H5 R 385 G.H5.17
Hydrophobic ICL2 T 145 34x55 G.hns1 A 39 G.hns1.03
Van-der-waals ICL2 T 145 34x55 G.hns1 A 39 G.hns1.03
Ionic TM6 H 243 6x29 G.H5 E 392 G.H5.24
Polar TM6 H 243 6x29 G.H5 E 392 G.H5.24
Hydrophobic TM6 H 243 6x29 G.H5 E 392 G.H5.24
Van-der-waals TM6 H 243 6x29 G.H5 E 392 G.H5.24
Hydrophobic TM6 M 247 6x33 G.H5 L 388 G.H5.20
Aromatic TM2 F 66 2x39 G.H5 Y 391 G.H5.23
Hydrophobic TM2 F 66 2x39 G.H5 Y 391 G.H5.23
Van-der-waals TM2 F 66 2x39 G.H5 Y 391 G.H5.23
Ionic ICL3 H 237 - G.hgh4 D 323 G.hgh4.13
Polar ICL3 H 237 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 H 237 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 H 237 - G.hgh4 D 323 G.hgh4.13
Hydrophobic TM1 A 54 1x60 G.H5 L 393 G.H5.25
Hydrophobic ICL2 I 141 34x51 G.S1 H 41 G.S1.02
Van-der-waals ICL2 I 141 34x51 G.S1 H 41 G.S1.02
Hydrophobic TM6 H 244 6x30 G.H5 R 385 G.H5.17
Hydrophobic H8 V 311 8x50 G.H5 L 394 G.H5.26
Van-der-waals H8 V 311 8x50 G.H5 L 394 G.H5.26
Ionic ICL3 R 238 - G.H5 D 381 G.H5.13
Polar ICL3 R 238 - G.H5 D 381 G.H5.13
Hydrophobic ICL3 R 238 - G.H5 D 381 G.H5.13
Van-der-waals ICL3 R 238 - G.H5 D 381 G.H5.13
Aromatic ICL2 H 143 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 H 143 34x53 G.H5 H 387 G.H5.19
Van-der-waals ICL2 H 143 34x53 G.H5 H 387 G.H5.19
Hydrophobic ICL2 T 145 34x55 G.hns1 R 38 G.hns1.02
Van-der-waals ICL2 T 145 34x55 G.hns1 R 38 G.hns1.02
Hydrophobic TM1 L 51 1x57 G.H5 L 393 G.H5.25
Hydrophobic TM3 V 137 3x54 G.H5 L 388 G.H5.20
Hydrophobic H8 N 314 8x53 G.H5 L 394 G.H5.26
Van-der-waals H8 N 314 8x53 G.H5 L 394 G.H5.26
Hydrophobic TM1 R 57 1x63 G.H5 L 394 G.H5.26
Van-der-waals TM1 R 57 1x63 G.H5 L 394 G.H5.26
Polar ICL3 Q 239 - G.H5 R 385 G.H5.17
Hydrophobic TM2 F 66 2x39 G.H5 L 393 G.H5.25
Hydrophobic ICL2 P 140 34x50 G.H5 Q 384 G.H5.16
Hydrophobic ICL3 R 238 - G.H5 R 385 G.H5.17
Van-der-waals ICL3 R 238 - G.H5 R 385 G.H5.17
Hydrophobic ICL2 P 140 34x50 G.H5 R 380 G.H5.12
Van-der-waals ICL2 P 140 34x50 G.H5 R 380 G.H5.12
Hydrophobic TM7 I 305 7x54 G.H5 L 393 G.H5.25
Van-der-waals TM7 I 305 7x54 G.H5 L 393 G.H5.25
Hydrophobic ICL3 H 237 - G.H4 L 346 G.H4.16
Polar ICL3 Q 236 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL3 Q 236 - G.hgh4 D 323 G.hgh4.13
Van-der-waals ICL3 Q 236 - G.hgh4 D 323 G.hgh4.13
Hydrophobic ICL2 P 140 34x50 G.H5 I 383 G.H5.15