Gt1 -
FP receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 83.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | P | 140 | 34x50 | G.H5 | T | 336 | G.H5.12 |
Van-der-waals | ICL2 | P | 140 | 34x50 | G.H5 | T | 336 | G.H5.12 |
Polar | ICL3 | Q | 236 | - | G.H4 | K | 300 | G.H4.12 |
Van-der-waals | ICL3 | Q | 236 | - | G.H4 | K | 300 | G.H4.12 |
Polar | ICL1 | K | 63 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL1 | K | 63 | - | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | ICL1 | K | 63 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL3 | H | 237 | - | G.S6 | Y | 316 | G.S6.02 |
Van-der-waals | ICL3 | H | 237 | - | G.S6 | Y | 316 | G.S6.02 |
Aromatic | TM6 | H | 243 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | H | 243 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Van-der-waals | TM6 | H | 243 | 6x29 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM6 | M | 247 | 6x33 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM6 | M | 247 | 6x33 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL2 | I | 141 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Van-der-waals | ICL2 | I | 141 | 34x51 | G.S3 | L | 190 | G.S3.01 |
Polar | ICL3 | Q | 239 | - | G.S6 | I | 315 | G.S6.01 |
Hydrophobic | ICL3 | Q | 239 | - | G.S6 | I | 315 | G.S6.01 |
Van-der-waals | ICL3 | Q | 239 | - | G.S6 | I | 315 | G.S6.01 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM3 | R | 133 | 3x50 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | V | 137 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM3 | V | 137 | 3x54 | G.H5 | L | 344 | G.H5.20 |
Hydrophobic | ICL2 | I | 141 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Van-der-waals | ICL2 | I | 141 | 34x51 | G.H5 | F | 332 | G.H5.08 |
Polar | ICL3 | H | 237 | - | G.S6 | S | 317 | G.S6.03 |
Van-der-waals | ICL3 | H | 237 | - | G.S6 | S | 317 | G.S6.03 |
Van-der-waals | ICL3 | Q | 239 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | ICL3 | Q | 239 | - | G.h4s6 | N | 307 | G.h4s6.02 |
Van-der-waals | ICL3 | Q | 239 | - | G.h4s6 | N | 307 | G.h4s6.02 |
Hydrophobic | TM6 | Q | 250 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | Q | 250 | 6x36 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL2 | P | 140 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Van-der-waals | ICL2 | P | 140 | 34x50 | G.H5 | I | 340 | G.H5.16 |
Polar | H8 | R | 308 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | H8 | R | 308 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | H8 | R | 308 | 8x47 | G.H5 | G | 348 | G.H5.24 |
Ionic | ICL3 | R | 238 | - | G.H5 | D | 337 | G.H5.13 |
Polar | ICL3 | R | 238 | - | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | ICL3 | R | 238 | - | G.H5 | D | 337 | G.H5.13 |
Polar | ICL2 | P | 140 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | P | 140 | 34x50 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM6 | M | 247 | 6x33 | G.H5 | F | 350 | G.H5.26 |
Hydrophobic | TM2 | F | 66 | 2x39 | G.H5 | G | 348 | G.H5.24 |
Van-der-waals | TM2 | F | 66 | 2x39 | G.H5 | G | 348 | G.H5.24 |
Ionic | TM5 | K | 233 | 5x69 | G.H5 | D | 333 | G.H5.09 |
Polar | TM5 | K | 233 | 5x69 | G.H5 | D | 333 | G.H5.09 |
Van-der-waals | TM5 | K | 233 | 5x69 | G.H5 | D | 333 | G.H5.09 |
Hydrophobic | ICL2 | T | 145 | 34x55 | G.hns1 | A | 27 | G.hns1.02 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM3 | R | 133 | 3x50 | G.H5 | L | 349 | G.H5.25 |
Polar | TM6 | H | 243 | 6x29 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | ICL2 | I | 141 | 34x51 | G.H5 | I | 339 | G.H5.15 |
Polar | ICL2 | H | 143 | 34x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | ICL2 | H | 143 | 34x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | ICL2 | H | 143 | 34x53 | G.H5 | N | 343 | G.H5.19 |
Polar | TM2 | S | 65 | 2x38 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL2 | S | 144 | 34x54 | G.hns1 | A | 27 | G.hns1.02 |
Polar | ICL3 | R | 238 | - | G.S6 | Y | 316 | G.S6.02 |
Hydrophobic | ICL3 | R | 238 | - | G.S6 | Y | 316 | G.S6.02 |
Van-der-waals | ICL3 | R | 238 | - | G.S6 | Y | 316 | G.S6.02 |
Polar | TM6 | R | 241 | 6x27 | G.h4s6 | R | 310 | G.h4s6.08 |
Van-der-waals | TM6 | R | 241 | 6x27 | G.h4s6 | R | 310 | G.h4s6.08 |
Hydrophobic | TM3 | V | 137 | 3x54 | G.H5 | I | 340 | G.H5.16 |
Polar | TM3 | E | 132 | 3x49 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM3 | E | 132 | 3x49 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL3 | G | 240 | - | G.h4s6 | R | 310 | G.h4s6.08 |
Van-der-waals | ICL3 | G | 240 | - | G.h4s6 | R | 310 | G.h4s6.08 |
Polar | TM6 | Q | 250 | 6x36 | G.H5 | G | 348 | G.H5.24 |
Hydrophobic | TM2 | F | 66 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Van-der-waals | TM2 | F | 66 | 2x39 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | TM6 | L | 251 | 6x37 | G.H5 | L | 349 | G.H5.25 |
Hydrophobic | ICL3 | Q | 239 | - | G.h4s6 | R | 310 | G.h4s6.08 |
Hydrophobic | ICL2 | S | 144 | 34x54 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | ICL2 | H | 143 | 34x53 | G.H5 | C | 347 | G.H5.23 |
Hydrophobic | ICL3 | R | 238 | - | G.S6 | I | 315 | G.S6.01 |
Van-der-waals | ICL3 | R | 238 | - | G.S6 | I | 315 | G.S6.01 |
Polar | ICL1 | S | 62 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL1 | S | 62 | - | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | ICL1 | S | 62 | - | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM5 | L | 227 | 5x63 | G.H5 | I | 340 | G.H5.16 |
Hydrophobic | TM5 | L | 227 | 5x63 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | TM5 | L | 227 | 5x63 | G.H5 | L | 344 | G.H5.20 |
Van-der-waals | ICL3 | H | 237 | - | G.S6 | I | 315 | G.S6.01 |
Hydrophobic | ICL2 | T | 145 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Van-der-waals | ICL2 | T | 145 | 34x55 | G.hns1 | R | 28 | G.hns1.03 |
Ionic | ICL3 | R | 238 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | ICL3 | R | 238 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | ICL3 | R | 238 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Van-der-waals | ICL3 | R | 238 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Hydrophobic | TM6 | R | 241 | 6x27 | G.h4s6 | D | 311 | G.h4s6.09 |
Hydrophobic | ICL1 | K | 61 | - | G.HN | A | 23 | G.HN.51 |
Van-der-waals | ICL1 | K | 61 | - | G.HN | A | 23 | G.HN.51 |
Hydrophobic | ICL1 | K | 63 | - | G.H5 | K | 345 | G.H5.21 |
Hydrophobic | ICL2 | P | 140 | 34x50 | G.H5 | I | 339 | G.H5.15 |
Hydrophobic | TM5 | V | 230 | 5x66 | G.H5 | D | 337 | G.H5.13 |
Van-der-waals | TM5 | V | 230 | 5x66 | G.H5 | D | 337 | G.H5.13 |
Polar | ICL3 | H | 237 | - | G.S6 | H | 318 | G.S6.04 |
Aromatic | ICL3 | H | 237 | - | G.S6 | H | 318 | G.S6.04 |
Hydrophobic | ICL3 | H | 237 | - | G.S6 | H | 318 | G.S6.04 |
Polar | TM2 | F | 66 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | TM2 | F | 66 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Van-der-waals | TM2 | F | 66 | 2x39 | G.H5 | D | 346 | G.H5.22 |
Hydrophobic | ICL3 | G | 240 | - | G.h4s6 | E | 314 | G.h4s6.12 |
Polar | ICL3 | Q | 239 | - | G.H4 | L | 304 | G.H4.16 |
Hydrophobic | ICL3 | Q | 239 | - | G.H4 | L | 304 | G.H4.16 |
Van-der-waals | ICL3 | Q | 239 | - | G.H4 | L | 304 | G.H4.16 |
Hydrophobic | TM4 | T | 148 | 4x38 | G.HN | K | 20 | G.HN.48 |
Hydrophobic | ICL2 | I | 141 | 34x51 | G.s2s3 | D | 189 | G.s2s3.02 |
Hydrophobic | TM6 | M | 247 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Van-der-waals | TM6 | M | 247 | 6x33 | G.H5 | L | 349 | G.H5.25 |
Polar | TM3 | G | 136 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Hydrophobic | TM3 | G | 136 | 3x53 | G.H5 | N | 343 | G.H5.19 |
Van-der-waals | TM3 | G | 136 | 3x53 | G.H5 | N | 343 | G.H5.19 |