Gt2 - PKR2 complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 81.8

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.9


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM5 L 250 5x65 G.H5 L 348 G.H5.20
Hydrophobic TM2 T 88 2x39 G.H5 C 351 G.H5.23
Polar TM6 Q 262 6x22 G.S6 I 319 G.S6.01
Polar ICL4 K 337 - G.H5 G 352 G.H5.24
Hydrophobic ICL4 K 337 - G.H5 G 352 G.H5.24
Van-der-waals ICL4 K 337 - G.H5 G 352 G.H5.24
Hydrophobic TM6 L 277 6x37 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 273 6x33 G.H5 L 348 G.H5.20
Hydrophobic C-term I 381 - G.h4s6 M 312 G.h4s6.03
Van-der-waals C-term I 381 - G.h4s6 M 312 G.h4s6.03
Hydrophobic TM5 P 256 5x71 G.S6 Y 320 G.S6.02
Hydrophobic TM4 Y 167 4x39 G.HN Q 24 G.HN.48
Van-der-waals TM4 Y 167 4x39 G.HN Q 24 G.HN.48
Hydrophobic TM5 G 257 5x72 G.S6 S 321 G.S6.03
Van-der-waals TM5 G 257 5x72 G.S6 S 321 G.S6.03
Hydrophobic ICL2 L 161 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 L 161 - G.H5 I 343 G.H5.15
Hydrophobic C-term L 383 - G.H3 H 244 G.H3.03
Polar TM5 G 257 5x72 G.S6 H 322 G.S6.04
Hydrophobic TM5 G 257 5x72 G.S6 H 322 G.S6.04
Van-der-waals TM5 G 257 5x72 G.S6 H 322 G.S6.04
Hydrophobic TM5 V 255 5x70 G.S6 Y 320 G.S6.02
Ionic ICL2 K 162 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM5 F 258 5x73 G.S6 H 322 G.S6.04
Hydrophobic TM5 P 256 5x71 G.H5 D 337 G.H5.09
Van-der-waals TM5 P 256 5x71 G.H5 D 337 G.H5.09
Hydrophobic TM3 A 156 3x53 G.H5 C 351 G.H5.23
Polar ICL2 R 164 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 R 164 - G.H5 C 351 G.H5.23
Van-der-waals ICL2 R 164 - G.H5 C 351 G.H5.23
Hydrophobic TM4 N 166 4x38 G.HN D 28 G.HN.52
Hydrophobic TM5 P 256 5x71 G.S6 H 322 G.S6.04
Hydrophobic ICL2 P 160 - G.H5 I 343 G.H5.15
Van-der-waals ICL2 P 160 - G.H5 I 343 G.H5.15
Ionic TM6 R 266 6x26 G.h4s6 E 318 G.h4s6.12
Polar TM6 R 266 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic TM6 R 266 6x26 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 R 266 6x26 G.h4s6 E 318 G.h4s6.12
Hydrophobic ICL2 P 163 - G.hns1 K 32 G.hns1.03
Van-der-waals ICL2 P 163 - G.hns1 K 32 G.hns1.03
Hydrophobic ICL2 R 164 - G.H5 D 350 G.H5.22
Polar TM2 N 86 2x37 G.H5 D 350 G.H5.22
Polar TM2 T 88 2x39 G.H5 D 350 G.H5.22
Hydrophobic TM2 T 88 2x39 G.H5 D 350 G.H5.22
Hydrophobic ICL2 P 160 - G.H5 I 344 G.H5.16
Van-der-waals ICL2 P 160 - G.H5 I 344 G.H5.16
Polar ICL4 K 337 - G.H5 C 351 G.H5.23
Van-der-waals ICL4 K 337 - G.H5 C 351 G.H5.23
Hydrophobic ICL2 L 161 - G.H5 F 336 G.H5.08
Polar ICL2 L 161 - G.S3 L 194 G.S3.01
Hydrophobic ICL2 L 161 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 L 161 - G.S3 L 194 G.S3.01
Ionic TM6 R 270 6x30 G.H5 D 341 G.H5.13
Polar TM6 R 270 6x30 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 270 6x30 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 270 6x30 G.H5 D 341 G.H5.13
Hydrophobic ICL2 K 162 - G.S3 L 194 G.S3.01
Hydrophobic TM5 V 255 5x70 G.H5 D 341 G.H5.13
Hydrophobic TM5 F 258 5x73 G.S6 M 323 G.S6.05
Van-der-waals TM5 F 258 5x73 G.S6 M 323 G.S6.05
Polar TM5 F 258 5x73 G.S6 S 321 G.S6.03
Hydrophobic TM5 F 258 5x73 G.S6 S 321 G.S6.03
Van-der-waals TM5 F 258 5x73 G.S6 S 321 G.S6.03
Polar TM6 Q 262 6x22 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM6 Q 262 6x22 G.h4s6 K 314 G.h4s6.08
Van-der-waals TM6 Q 262 6x22 G.h4s6 K 314 G.h4s6.08
Hydrophobic TM3 I 157 3x54 G.H5 L 348 G.H5.20
Van-der-waals TM3 I 157 3x54 G.H5 L 348 G.H5.20
Polar ICL2 P 160 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 P 163 - G.s2s3 D 193 G.s2s3.02
Hydrophobic TM6 Q 262 6x22 G.h4s6 E 318 G.h4s6.12
Van-der-waals TM6 Q 262 6x22 G.h4s6 E 318 G.h4s6.12
Polar TM6 T 273 6x33 G.H5 L 353 G.H5.25
Hydrophobic TM6 T 273 6x33 G.H5 L 353 G.H5.25
Van-der-waals TM6 T 273 6x33 G.H5 L 353 G.H5.25
Polar ICL2 R 164 - G.H5 N 347 G.H5.19
Hydrophobic ICL2 R 164 - G.H5 N 347 G.H5.19
Van-der-waals ICL2 R 164 - G.H5 N 347 G.H5.19
Aromatic TM5 F 258 5x73 G.H4 K 304 G.H4.12
Hydrophobic TM5 F 258 5x73 G.H4 K 304 G.H4.12
Van-der-waals TM5 F 258 5x73 G.H4 K 304 G.H4.12
Hydrophobic ICL2 L 161 - G.s2s3 K 192 G.s2s3.01
Van-der-waals ICL2 L 161 - G.s2s3 K 192 G.s2s3.01
Hydrophobic TM3 I 157 3x54 G.H5 L 353 G.H5.25
Van-der-waals TM3 I 157 3x54 G.H5 L 353 G.H5.25
Hydrophobic ICL2 L 161 - G.H5 T 340 G.H5.12
Hydrophobic TM5 P 256 5x71 G.H5 A 338 G.H5.10
Van-der-waals TM5 P 256 5x71 G.H5 A 338 G.H5.10
Hydrophobic ICL2 L 161 - G.S3 F 196 G.S3.03
Hydrophobic ICL2 L 161 - G.S2 V 191 G.S2.08
Hydrophobic ICL2 P 160 - G.S3 L 194 G.S3.01
Van-der-waals ICL2 P 160 - G.S3 L 194 G.S3.01
Hydrophobic TM3 R 153 3x50 G.H5 L 353 G.H5.25
Hydrophobic ICL4 K 337 - G.H5 L 353 G.H5.25
Van-der-waals ICL4 K 337 - G.H5 L 353 G.H5.25
Ionic C-term E 376 - G.H3 K 257 G.H3.16
Polar C-term E 376 - G.H3 K 257 G.H3.16
Ionic TM6 R 266 6x26 G.H5 D 341 G.H5.13
Polar TM6 R 266 6x26 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 266 6x26 G.H5 D 341 G.H5.13
Van-der-waals TM6 R 266 6x26 G.H5 D 341 G.H5.13
Hydrophobic ICL2 P 160 - G.H5 T 340 G.H5.12
Hydrophobic C-term L 383 - G.H3 H 248 G.H3.07
Polar TM3 A 156 3x53 G.H5 N 347 G.H5.19
Hydrophobic TM3 A 156 3x53 G.H5 N 347 G.H5.19
Van-der-waals TM3 A 156 3x53 G.H5 N 347 G.H5.19
Polar TM6 Q 262 6x22 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 Q 262 6x22 G.h4s6 K 317 G.h4s6.11
Van-der-waals TM6 Q 262 6x22 G.h4s6 K 317 G.h4s6.11
Hydrophobic TM6 R 270 6x30 G.H5 I 344 G.H5.16
Hydrophobic TM5 L 250 5x65 G.H5 I 344 G.H5.16
Hydrophobic ICL3 T 260 - G.H4 L 308 G.H4.16
Van-der-waals ICL3 T 260 - G.H4 L 308 G.H4.16
Hydrophobic TM5 P 256 5x71 G.H5 D 341 G.H5.13
Hydrophobic TM6 R 266 6x26 G.H5 K 345 G.H5.17
Van-der-waals TM6 R 266 6x26 G.H5 K 345 G.H5.17
Hydrophobic TM3 R 153 3x50 G.H5 C 351 G.H5.23
Polar TM6 R 266 6x26 G.S6 Y 320 G.S6.02
Hydrophobic TM6 R 266 6x26 G.S6 Y 320 G.S6.02
Van-der-waals TM6 R 266 6x26 G.S6 Y 320 G.S6.02