G12 -
PrRP receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM6 | R | 272 | 6x29 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | R | 272 | 6x29 | G.H5 | Q | 372 | G.H5.17 |
Ionic | ICL2 | R | 170 | - | G.H5 | D | 377 | G.H5.22 |
Polar | ICL2 | R | 170 | - | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | ECL2 | E | 213 | 45x52 | G.HN | S | 2 | G.HN.02 |
Van-der-waals | ECL2 | E | 213 | 45x52 | G.HN | S | 2 | G.HN.02 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM5 | P | 258 | 5x71 | G.H5 | H | 364 | G.H5.09 |
Polar | H8 | D | 340 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | D | 340 | 8x48 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | T | 276 | 6x33 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | L | 163 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM3 | L | 163 | 3x54 | G.H5 | L | 375 | G.H5.20 |
Polar | TM2 | A | 121 | 2x64 | G.HN | R | 6 | G.HN.06 |
Hydrophobic | TM2 | A | 121 | 2x64 | G.HN | R | 6 | G.HN.06 |
Van-der-waals | TM2 | A | 121 | 2x64 | G.HN | R | 6 | G.HN.06 |
Polar | TM2 | Y | 120 | 2x63 | G.HN | V | 5 | G.HN.05 |
Hydrophobic | TM2 | Y | 120 | 2x63 | G.HN | V | 5 | G.HN.05 |
Van-der-waals | TM2 | Y | 120 | 2x63 | G.HN | V | 5 | G.HN.05 |
Hydrophobic | TM5 | P | 258 | 5x71 | G.H5 | D | 368 | G.H5.13 |
Polar | TM6 | R | 272 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | R | 272 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM6 | R | 272 | 6x29 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM7 | H | 321 | 7x38 | G.HN | V | 4 | G.HN.04 |
Polar | ECL1 | V | 128 | 23x51 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | ECL1 | V | 128 | 23x51 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | ECL1 | V | 128 | 23x51 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | TM3 | R | 159 | 3x50 | G.H5 | M | 379 | G.H5.24 |
Polar | TM3 | R | 159 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | R | 159 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | R | 159 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | I | 370 | - | G.H2 | F | 239 | G.H2.08 |
Polar | ECL1 | G | 126 | 23x49 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | ECL1 | G | 126 | 23x49 | G.HN | S | 9 | G.HN.09 |
Polar | ICL1 | H | 92 | 12x51 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ICL1 | H | 92 | 12x51 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | ICL1 | H | 92 | 12x51 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | ECL1 | F | 129 | 23x52 | G.HN | L | 8 | G.HN.08 |
Van-der-waals | ECL1 | F | 129 | 23x52 | G.HN | L | 8 | G.HN.08 |
Hydrophobic | TM5 | P | 258 | 5x71 | G.H5 | F | 361 | G.H5.06 |
Van-der-waals | TM5 | P | 258 | 5x71 | G.H5 | F | 361 | G.H5.06 |
Hydrophobic | ECL2 | L | 210 | - | G.HN | T | 7 | G.HN.07 |
Polar | ECL1 | W | 127 | 23x50 | G.HN | T | 7 | G.HN.07 |
Van-der-waals | ECL1 | W | 127 | 23x50 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM3 | F | 138 | 3x29 | G.HN | G | 3 | G.HN.03 |
Van-der-waals | TM3 | F | 138 | 3x29 | G.HN | G | 3 | G.HN.03 |
Hydrophobic | TM6 | L | 280 | 6x37 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | L | 280 | 6x37 | G.H5 | M | 379 | G.H5.24 |
Polar | TM6 | Q | 265 | 6x22 | G.h4s6 | R | 342 | G.h4s6.11 |
Polar | TM6 | R | 301 | 6x58 | G.HN | S | 2 | G.HN.02 |
Hydrophobic | TM6 | R | 301 | 6x58 | G.HN | S | 2 | G.HN.02 |
Van-der-waals | TM6 | R | 301 | 6x58 | G.HN | S | 2 | G.HN.02 |
Polar | ECL1 | F | 129 | 23x52 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | ECL1 | F | 129 | 23x52 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | ECL1 | F | 129 | 23x52 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | TM3 | V | 162 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | V | 162 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL2 | P | 166 | 34x50 | G.H5 | L | 371 | G.H5.16 |
Polar | TM2 | E | 123 | 2x66 | G.HN | S | 9 | G.HN.09 |
Polar | H8 | H | 339 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | H8 | H | 339 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | H8 | H | 339 | 8x47 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL1 | L | 91 | 12x50 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | L | 167 | 34x51 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM5 | G | 259 | 5x72 | G.H5 | F | 361 | G.H5.06 |
Polar | TM2 | Y | 120 | 2x63 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM2 | Y | 120 | 2x63 | G.HN | T | 7 | G.HN.07 |
Van-der-waals | TM2 | Y | 120 | 2x63 | G.HN | T | 7 | G.HN.07 |
Polar | ICL1 | R | 90 | 12x49 | G.HN | R | 52 | G.HN.52 |
Polar | ICL2 | P | 166 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | P | 166 | 34x50 | G.H5 | N | 374 | G.H5.19 |
Polar | TM3 | Y | 146 | 3x37 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | Y | 146 | 3x37 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | Y | 146 | 3x37 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | L | 163 | 3x54 | G.H5 | N | 374 | G.H5.19 |
Polar | TM6 | Q | 265 | 6x22 | G.h4s6 | K | 344 | G.h4s6.19 |
Hydrophobic | TM6 | Q | 265 | 6x22 | G.h4s6 | K | 344 | G.h4s6.19 |
Polar | TM2 | E | 123 | 2x66 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | TM2 | E | 123 | 2x66 | G.HN | T | 7 | G.HN.07 |
Van-der-waals | TM2 | E | 123 | 2x66 | G.HN | T | 7 | G.HN.07 |
Polar | TM6 | D | 269 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM6 | D | 269 | 6x26 | G.H5 | Q | 372 | G.H5.17 |
Ionic | ICL1 | R | 89 | 12x48 | G.HN | D | 42 | G.HN.42 |
Polar | ICL1 | R | 89 | 12x48 | G.HN | D | 42 | G.HN.42 |
Van-der-waals | ICL1 | R | 89 | 12x48 | G.HN | D | 42 | G.HN.42 |
Polar | H8 | H | 339 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | H8 | H | 339 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | H | 339 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM2 | N | 93 | 2x37 | G.HN | R | 52 | G.HN.52 |
Van-der-waals | TM2 | N | 93 | 2x37 | G.HN | R | 52 | G.HN.52 |
Hydrophobic | TM7 | Q | 317 | 7x34 | G.HN | V | 5 | G.HN.05 |
Van-der-waals | TM7 | Q | 317 | 7x34 | G.HN | V | 5 | G.HN.05 |
Polar | H8 | S | 341 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | H8 | S | 341 | 8x49 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM2 | A | 119 | 2x62 | G.HN | L | 8 | G.HN.08 |
Van-der-waals | TM2 | A | 119 | 2x62 | G.HN | L | 8 | G.HN.08 |
Polar | TM3 | V | 162 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM3 | V | 162 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | TM3 | V | 162 | 3x53 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL1 | R | 89 | 12x48 | G.HN | A | 45 | G.HN.45 |
Hydrophobic | TM7 | L | 318 | 7x35 | G.HN | V | 5 | G.HN.05 |
Hydrophobic | TM6 | Q | 265 | 6x22 | G.h4s6 | P | 345 | G.h4s6.20 |
Van-der-waals | TM6 | Q | 265 | 6x22 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM5 | R | 255 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | R | 255 | 5x68 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM2 | Y | 120 | 2x63 | G.HN | V | 4 | G.HN.04 |
Van-der-waals | TM2 | Y | 120 | 2x63 | G.HN | V | 4 | G.HN.04 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Van-der-waals | ICL2 | L | 167 | 34x51 | G.S3 | I | 221 | G.S3.01 |
Hydrophobic | N-term | L | 53 | - | G.HN | R | 6 | G.HN.06 |
Polar | TM6 | T | 276 | 6x33 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | T | 276 | 6x33 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM5 | G | 259 | 5x72 | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | TM5 | G | 259 | 5x72 | G.S6 | H | 348 | G.S6.03 |
Polar | TM6 | R | 272 | 6x29 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | R | 272 | 6x29 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | R | 272 | 6x29 | G.H5 | Q | 381 | G.H5.26 |
Polar | ICL2 | R | 169 | 34x53 | G.HN | A | 53 | G.HN.53 |
Hydrophobic | ICL2 | R | 169 | 34x53 | G.HN | A | 53 | G.HN.53 |
Polar | ECL1 | G | 126 | 23x49 | G.HN | T | 7 | G.HN.07 |
Hydrophobic | ECL1 | G | 126 | 23x49 | G.HN | T | 7 | G.HN.07 |
Van-der-waals | ECL1 | G | 126 | 23x49 | G.HN | T | 7 | G.HN.07 |
Polar | TM2 | Y | 120 | 2x63 | G.HN | L | 8 | G.HN.08 |
Hydrophobic | TM2 | Y | 120 | 2x63 | G.HN | L | 8 | G.HN.08 |
Van-der-waals | TM2 | Y | 120 | 2x63 | G.HN | L | 8 | G.HN.08 |
Hydrophobic | TM2 | F | 122 | 2x65 | G.HN | L | 8 | G.HN.08 |
Polar | TM7 | Q | 317 | 7x34 | G.HN | G | 3 | G.HN.03 |
Polar | TM2 | P | 124 | 2x67 | G.HN | R | 6 | G.HN.06 |
Van-der-waals | TM2 | P | 124 | 2x67 | G.HN | R | 6 | G.HN.06 |
Hydrophobic | TM5 | V | 257 | 5x70 | G.h4s6 | P | 345 | G.h4s6.20 |
Hydrophobic | TM5 | P | 258 | 5x71 | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | TM5 | P | 258 | 5x71 | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | TM2 | T | 95 | 2x39 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | ICL2 | R | 170 | - | G.hns1 | R | 55 | G.hns1.02 |
Polar | TM5 | C | 260 | 5x73 | G.S6 | H | 348 | G.S6.03 |
Hydrophobic | TM5 | C | 260 | 5x73 | G.S6 | H | 348 | G.S6.03 |
Van-der-waals | TM5 | C | 260 | 5x73 | G.S6 | H | 348 | G.S6.03 |
Polar | ECL1 | W | 127 | 23x50 | G.HN | S | 9 | G.HN.09 |
Van-der-waals | ECL1 | W | 127 | 23x50 | G.HN | S | 9 | G.HN.09 |
Hydrophobic | ICL2 | R | 169 | 34x53 | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | TM5 | L | 252 | 5x65 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM5 | V | 257 | 5x70 | G.S6 | F | 347 | G.S6.02 |
Van-der-waals | TM5 | V | 257 | 5x70 | G.S6 | F | 347 | G.S6.02 |
Hydrophobic | TM7 | Q | 317 | 7x34 | G.HN | V | 4 | G.HN.04 |
Van-der-waals | TM7 | Q | 317 | 7x34 | G.HN | V | 4 | G.HN.04 |
Ionic | TM5 | R | 255 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Polar | TM5 | R | 255 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM5 | R | 255 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM5 | R | 255 | 5x68 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | R | 272 | 6x29 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM6 | R | 272 | 6x29 | G.H5 | K | 376 | G.H5.21 |
Hydrophobic | TM6 | H | 295 | 6x52 | G.HN | M | 1 | G.HN.01 |
Polar | TM5 | R | 255 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | TM5 | R | 255 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Van-der-waals | TM5 | R | 255 | 5x68 | G.H5 | Q | 372 | G.H5.17 |
Hydrophobic | ECL1 | F | 129 | 23x52 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM3 | P | 142 | 3x33 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | P | 142 | 3x33 | G.HN | M | 1 | G.HN.01 |
Polar | ECL1 | V | 128 | 23x51 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | ECL1 | V | 128 | 23x51 | G.HN | C | 11 | G.HN.11 |
Van-der-waals | ECL1 | V | 128 | 23x51 | G.HN | C | 11 | G.HN.11 |
Hydrophobic | TM2 | Y | 120 | 2x63 | G.HN | R | 6 | G.HN.06 |
Van-der-waals | TM2 | Y | 120 | 2x63 | G.HN | R | 6 | G.HN.06 |
Hydrophobic | TM2 | A | 121 | 2x64 | G.HN | V | 5 | G.HN.05 |
Van-der-waals | TM2 | A | 121 | 2x64 | G.HN | V | 5 | G.HN.05 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.H5 | V | 366 | G.H5.11 |
Hydrophobic | TM6 | T | 276 | 6x33 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | P | 166 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | P | 166 | 34x50 | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM6 | W | 291 | 6x48 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | L | 163 | 3x54 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ECL2 | V | 208 | - | G.HN | R | 6 | G.HN.06 |
Hydrophobic | ICL2 | R | 170 | - | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | V | 145 | 3x36 | G.HN | M | 1 | G.HN.01 |
Van-der-waals | TM3 | V | 145 | 3x36 | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM5 | P | 258 | 5x71 | G.H5 | A | 365 | G.H5.10 |
Van-der-waals | TM5 | P | 258 | 5x71 | G.H5 | A | 365 | G.H5.10 |
Hydrophobic | TM5 | L | 252 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Van-der-waals | TM5 | L | 252 | 5x65 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM3 | L | 163 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM3 | L | 163 | 3x54 | G.H5 | L | 371 | G.H5.16 |
Polar | ICL1 | R | 89 | 12x48 | G.HN | R | 41 | G.HN.41 |
Hydrophobic | ICL1 | R | 89 | 12x48 | G.HN | R | 41 | G.HN.41 |
Van-der-waals | ICL1 | R | 89 | 12x48 | G.HN | R | 41 | G.HN.41 |
Hydrophobic | TM2 | E | 123 | 2x66 | G.HN | L | 8 | G.HN.08 |
Van-der-waals | TM2 | E | 123 | 2x66 | G.HN | L | 8 | G.HN.08 |
Hydrophobic | ICL2 | P | 166 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | ICL2 | P | 166 | 34x50 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Van-der-waals | ICL2 | L | 167 | 34x51 | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.S1 | V | 58 | G.S1.02 |
Hydrophobic | C-term | I | 370 | - | G.h2s4 | F | 242 | G.h2s4.01 |
Hydrophobic | TM2 | T | 117 | 2x60 | G.HN | V | 4 | G.HN.04 |
Van-der-waals | TM2 | T | 117 | 2x60 | G.HN | V | 4 | G.HN.04 |
Polar | ICL2 | R | 170 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | R | 170 | - | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | R | 170 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | TM6 | L | 279 | 6x36 | G.H5 | M | 379 | G.H5.24 |