G15 -
PrRP receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 80.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM6 | W | 268 | 6x25 | G.h4s6 | S | 336 | G.h4s6.18 |
Van-der-waals | TM6 | R | 272 | 6x29 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.H5 | V | 359 | G.H5.11 |
Hydrophobic | C-term | H | 360 | - | G.HN | M | 1 | G.HN.01 |
Polar | TM6 | T | 276 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM6 | T | 276 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | TM6 | T | 276 | 6x33 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Van-der-waals | ICL2 | L | 167 | 34x51 | G.S1 | L | 43 | G.S1.02 |
Hydrophobic | TM7 | Y | 335 | 7x53 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM7 | Y | 335 | 7x53 | G.H5 | L | 374 | G.H5.26 |
Polar | TM6 | R | 272 | 6x29 | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | TM6 | R | 272 | 6x29 | G.H5 | A | 365 | G.H5.17 |
Van-der-waals | TM6 | R | 272 | 6x29 | G.H5 | A | 365 | G.H5.17 |
Hydrophobic | TM5 | L | 252 | 5x65 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | L | 163 | 3x54 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM5 | V | 257 | 5x70 | G.S6 | F | 340 | G.S6.02 |
Hydrophobic | TM5 | V | 257 | 5x70 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | P | 258 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | P | 258 | 5x71 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | P | 258 | 5x71 | G.S6 | F | 340 | G.S6.02 |
Van-der-waals | TM5 | P | 258 | 5x71 | G.S6 | F | 340 | G.S6.02 |
Polar | ICL2 | R | 170 | - | G.H5 | Y | 367 | G.H5.19 |
Aromatic | ICL2 | R | 170 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | R | 170 | - | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | R | 170 | - | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | TM2 | N | 96 | 2x40 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM2 | N | 96 | 2x40 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM5 | R | 255 | 5x68 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | W | 268 | 6x25 | G.H5 | D | 369 | G.H5.21 |
Polar | TM5 | V | 256 | 5x69 | G.H5 | K | 357 | G.H5.09 |
Van-der-waals | TM5 | V | 256 | 5x69 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | C-term | I | 370 | - | G.H2 | R | 216 | G.H2.04 |
Hydrophobic | TM5 | L | 252 | 5x65 | G.H5 | L | 364 | G.H5.16 |
Polar | TM7 | A | 336 | 7x54 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | TM7 | A | 336 | 7x54 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM7 | A | 336 | 7x54 | G.H5 | L | 374 | G.H5.26 |
Polar | TM6 | R | 272 | 6x29 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM6 | R | 272 | 6x29 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM6 | R | 272 | 6x29 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | ICL3 | T | 262 | - | G.H4 | T | 317 | G.H4.16 |
Van-der-waals | ICL3 | T | 262 | - | G.H4 | T | 317 | G.H4.16 |
Hydrophobic | TM6 | W | 268 | 6x25 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | W | 268 | 6x25 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM3 | L | 163 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Van-der-waals | TM3 | L | 163 | 3x54 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM2 | T | 95 | 2x39 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM2 | T | 95 | 2x39 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | C-term | I | 370 | - | G.H2 | I | 220 | G.H2.08 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Van-der-waals | ICL2 | L | 167 | 34x51 | G.H5 | F | 356 | G.H5.08 |
Polar | H8 | H | 339 | 8x47 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | H8 | H | 339 | 8x47 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | H8 | H | 339 | 8x47 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM2 | I | 99 | 2x43 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | TM2 | I | 99 | 2x43 | G.H5 | L | 374 | G.H5.26 |
Polar | TM6 | Q | 265 | 6x22 | G.S6 | L | 339 | G.S6.01 |
Hydrophobic | TM6 | Q | 265 | 6x22 | G.S6 | L | 339 | G.S6.01 |
Van-der-waals | TM6 | Q | 265 | 6x22 | G.S6 | L | 339 | G.S6.01 |
Polar | TM5 | C | 260 | 5x73 | G.S6 | S | 341 | G.S6.03 |
Van-der-waals | TM5 | C | 260 | 5x73 | G.S6 | S | 341 | G.S6.03 |
Hydrophobic | ICL2 | P | 166 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | P | 166 | 34x50 | G.H5 | R | 360 | G.H5.12 |
Ionic | TM5 | R | 255 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Polar | TM5 | R | 255 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | TM5 | R | 255 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Van-der-waals | TM5 | R | 255 | 5x68 | G.H5 | D | 361 | G.H5.13 |
Hydrophobic | ICL2 | P | 166 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Van-der-waals | ICL2 | P | 166 | 34x50 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM5 | P | 258 | 5x71 | G.S6 | H | 342 | G.S6.04 |
Ionic | H8 | E | 344 | 8x52 | G.h4s6 | K | 332 | G.h4s6.14 |
Polar | H8 | E | 344 | 8x52 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | H8 | E | 344 | 8x52 | G.h4s6 | K | 332 | G.h4s6.14 |
Van-der-waals | H8 | E | 344 | 8x52 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Van-der-waals | ICL2 | L | 167 | 34x51 | G.H5 | R | 360 | G.H5.12 |
Polar | H8 | D | 340 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | H8 | D | 340 | 8x48 | G.h4s6 | K | 332 | G.h4s6.14 |
Hydrophobic | TM6 | W | 268 | 6x25 | G.h4s6 | R | 335 | G.h4s6.17 |
Van-der-waals | TM6 | W | 268 | 6x25 | G.h4s6 | R | 335 | G.h4s6.17 |
Polar | ICL2 | R | 169 | 34x53 | G.HN | K | 37 | G.HN.52 |
Van-der-waals | ICL2 | R | 169 | 34x53 | G.HN | K | 37 | G.HN.52 |
Hydrophobic | C-term | V | 368 | - | G.H3 | W | 266 | G.H3.17 |
Van-der-waals | C-term | V | 368 | - | G.H3 | W | 266 | G.H3.17 |
Polar | H8 | H | 339 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | H8 | H | 339 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Van-der-waals | H8 | H | 339 | 8x47 | G.H5 | N | 372 | G.H5.24 |
Hydrophobic | TM5 | R | 255 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM5 | R | 255 | 5x68 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | P | 258 | 5x71 | G.H5 | D | 358 | G.H5.10 |
Van-der-waals | TM5 | P | 258 | 5x71 | G.H5 | D | 358 | G.H5.10 |
Hydrophobic | C-term | V | 368 | - | G.H2 | I | 220 | G.H2.08 |
Polar | TM6 | Q | 265 | 6x22 | G.h4s6 | Y | 320 | G.h4s6.02 |
Polar | ICL2 | L | 167 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Van-der-waals | ICL2 | L | 167 | 34x51 | G.S3 | T | 202 | G.S3.01 |
Hydrophobic | TM6 | Q | 265 | 6x22 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | A | 358 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | C-term | A | 358 | - | G.HN | M | 1 | G.HN.01 |
Polar | H8 | S | 341 | 8x49 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | H8 | S | 341 | 8x49 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | H8 | S | 341 | 8x49 | G.H5 | L | 373 | G.H5.25 |
Ionic | TM6 | D | 269 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Polar | TM6 | D | 269 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | TM6 | D | 269 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Van-der-waals | TM6 | D | 269 | 6x26 | G.h4s6 | R | 338 | G.h4s6.20 |
Hydrophobic | C-term | V | 368 | - | G.H3 | L | 264 | G.H3.15 |
Van-der-waals | C-term | V | 368 | - | G.H3 | L | 264 | G.H3.15 |
Hydrophobic | C-term | I | 370 | - | G.h2s4 | F | 223 | G.h2s4.01 |
Hydrophobic | TM5 | G | 259 | 5x72 | G.S6 | S | 341 | G.S6.03 |
Van-der-waals | TM5 | G | 259 | 5x72 | G.S6 | S | 341 | G.S6.03 |
Ionic | H8 | D | 340 | 8x48 | G.h4s6 | R | 335 | G.h4s6.17 |
Hydrophobic | TM5 | P | 258 | 5x71 | G.H5 | K | 357 | G.H5.09 |
Hydrophobic | TM3 | L | 163 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Van-der-waals | TM3 | L | 163 | 3x54 | G.H5 | I | 371 | G.H5.23 |
Hydrophobic | TM6 | T | 276 | 6x33 | G.H5 | L | 368 | G.H5.20 |
Hydrophobic | TM3 | L | 163 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Van-der-waals | TM3 | L | 163 | 3x54 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | G | 259 | 5x72 | G.S6 | H | 342 | G.S6.04 |
Van-der-waals | TM5 | G | 259 | 5x72 | G.S6 | H | 342 | G.S6.04 |
Polar | ICL2 | P | 166 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Hydrophobic | ICL2 | P | 166 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | ICL2 | P | 166 | 34x50 | G.H5 | Y | 367 | G.H5.19 |
Ionic | TM6 | R | 272 | 6x29 | G.H5 | D | 369 | G.H5.21 |
Polar | TM6 | R | 272 | 6x29 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | TM6 | R | 272 | 6x29 | G.H5 | D | 369 | G.H5.21 |
Van-der-waals | TM6 | R | 272 | 6x29 | G.H5 | D | 369 | G.H5.21 |
Hydrophobic | ICL2 | L | 167 | 34x51 | G.H5 | V | 363 | G.H5.15 |
Hydrophobic | TM3 | R | 159 | 3x50 | G.H5 | I | 371 | G.H5.23 |
Polar | H8 | H | 339 | 8x47 | G.H5 | L | 373 | G.H5.25 |
Hydrophobic | H8 | H | 339 | 8x47 | G.H5 | L | 373 | G.H5.25 |
Van-der-waals | H8 | H | 339 | 8x47 | G.H5 | L | 373 | G.H5.25 |
Polar | C-term | P | 359 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | C-term | P | 359 | - | G.HN | M | 1 | G.HN.01 |
Van-der-waals | C-term | P | 359 | - | G.HN | M | 1 | G.HN.01 |
Hydrophobic | TM3 | V | 162 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Van-der-waals | TM3 | V | 162 | 3x53 | G.H5 | Y | 367 | G.H5.19 |
Ionic | ICL2 | R | 170 | - | G.H5 | E | 370 | G.H5.22 |
Polar | ICL2 | R | 170 | - | G.H5 | E | 370 | G.H5.22 |
Hydrophobic | ICL2 | R | 170 | - | G.H5 | E | 370 | G.H5.22 |
Van-der-waals | ICL2 | R | 170 | - | G.H5 | E | 370 | G.H5.22 |
Polar | H8 | H | 339 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | H8 | H | 339 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Van-der-waals | H8 | H | 339 | 8x47 | G.H5 | L | 374 | G.H5.26 |
Hydrophobic | ICL2 | P | 166 | 34x50 | G.H5 | L | 364 | G.H5.16 |
Hydrophobic | TM5 | C | 260 | 5x73 | G.H4 | L | 313 | G.H4.12 |