GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 87.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 11.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
Gβ,
Gγ,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | A | 209 | 5x64 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | L | 120 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | L | 120 | 34x51 | G.S1 | L | 40 | G.S1.02 |
Polar | ICL3 | N | 213 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL3 | N | 213 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | N | 213 | - | G.H5 | D | 346 | G.H5.13 |
Polar | TM3 | V | 117 | 3x55 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM3 | D | 111 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | D | 111 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Polar | ICL3 | A | 215 | - | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | ICL3 | A | 215 | - | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | ICL3 | A | 215 | - | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM3 | V | 116 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | V | 116 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | P | 119 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | H8 | T | 294 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | T | 294 | 8x47 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | L | 336 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | L | 336 | - | G.H3 | L | 254 | G.H3.08 |
Polar | H8 | T | 296 | 8x49 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM6 | I | 224 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Polar | C-term | D | 329 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | C-term | D | 329 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | D | 329 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | C-term | D | 329 | - | G.H2 | I | 217 | G.H2.08 |
Polar | H8 | E | 295 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | H8 | E | 295 | 8x48 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | L | 120 | 34x51 | G.H5 | F | 341 | G.H5.08 |
Hydrophobic | TM6 | I | 224 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Polar | TM7 | Y | 290 | 7x53 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | L | 120 | 34x51 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | L | 336 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | L | 336 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | L | 336 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 336 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | ICL2 | P | 119 | 34x50 | G.H5 | N | 352 | G.H5.19 |
Polar | H8 | T | 296 | 8x49 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | A | 115 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | A | 115 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | P | 119 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | P | 119 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM2 | L | 49 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | L | 49 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | K | 214 | - | G.S6 | Y | 325 | G.S6.02 |
Ionic | ICL1 | E | 46 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL1 | E | 46 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL1 | E | 46 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL1 | E | 46 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | ICL2 | R | 126 | 34x57 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | R | 126 | 34x57 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | ICL2 | R | 126 | 34x57 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | L | 333 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | L | 333 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | ICL2 | P | 119 | 34x50 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL3 | A | 215 | - | G.H5 | T | 347 | G.H5.14 |
Polar | ICL3 | K | 214 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | K | 214 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM6 | I | 224 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | I | 224 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Ionic | ICL2 | K | 121 | 34x52 | G.s2s3 | E | 197 | G.s2s3.01 |
Polar | ICL2 | K | 121 | 34x52 | G.s2s3 | E | 197 | G.s2s3.01 |
Van-der-waals | ICL2 | K | 121 | 34x52 | G.s2s3 | E | 197 | G.s2s3.01 |
Hydrophobic | ICL3 | K | 214 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | K | 214 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Ionic | C-term | E | 337 | - | G.H2 | R | 214 | G.H2.05 |
Polar | C-term | E | 337 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | E | 337 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | E | 337 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | ICL2 | L | 120 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | L | 120 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Hydrophobic | ICL3 | A | 215 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | ICL3 | A | 215 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Polar | TM3 | R | 112 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM3 | R | 112 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | R | 112 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | R | 112 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | L | 120 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | L | 120 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Polar | TM1 | Q | 42 | 1x60 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM1 | Q | 42 | 1x60 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM1 | Q | 42 | 1x60 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM6 | R | 223 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | R | 223 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM3 | V | 116 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | ICL3 | N | 213 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL3 | N | 213 | - | G.H5 | L | 349 | G.H5.16 |
Polar | TM3 | A | 115 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | A | 115 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | A | 115 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Polar | C-term | E | 332 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | E | 332 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | E | 332 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM6 | L | 227 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM2 | L | 49 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | L | 53 | 2x43 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | V | 116 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Polar | C-term | L | 333 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | L | 333 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | TM6 | E | 217 | 6x26 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | TM6 | E | 217 | 6x26 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM2 | E | 48 | 2x38 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM2 | E | 48 | 2x38 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | E | 48 | 2x38 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL3 | T | 216 | - | G.H5 | L | 353 | G.H5.20 |
Polar | ICL3 | A | 215 | - | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | ICL3 | A | 215 | - | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM5 | V | 210 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM5 | V | 210 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | E | 220 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL3 | A | 215 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | TM6 | L | 228 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Polar | H8 | T | 296 | 8x49 | G.H5 | K | 354 | G.H5.21 |
Polar | TM3 | R | 112 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 112 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 112 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | H8 | T | 294 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | T | 294 | 8x47 | G.H5 | N | 357 | G.H5.24 |