G14 -
PAF receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 85.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 12.4
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Ionic | TM7 | K | 298 | 7x58 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | TM7 | K | 298 | 7x58 | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | TM7 | K | 298 | 7x58 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | TM6 | V | 226 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | V | 226 | 6x30 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | ICL3 | Q | 219 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | Q | 219 | - | G.S6 | Y | 321 | G.S6.02 |
Polar | ICL2 | Q | 127 | 34x55 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 127 | 34x55 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 127 | 34x55 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | TM6 | A | 230 | 6x34 | G.H5 | V | 355 | G.H5.26 |
Polar | TM6 | A | 230 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 230 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | A | 230 | 6x34 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | V | 226 | 6x30 | G.H5 | L | 349 | G.H5.20 |
Polar | TM6 | N | 223 | 6x27 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | N | 223 | 6x27 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | TM6 | R | 229 | 6x33 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | ICL2 | I | 123 | 34x51 | G.H5 | K | 341 | G.H5.12 |
Hydrophobic | TM6 | V | 234 | 6x38 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | V | 234 | 6x38 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | L | 354 | G.H5.25 |
Ionic | TM6 | R | 222 | 6x26 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | TM6 | R | 222 | 6x26 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | TM6 | R | 222 | 6x26 | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | TM6 | R | 222 | 6x26 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | TM2 | N | 50 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | N | 50 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | TM2 | N | 50 | 2x37 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | TM2 | I | 52 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | I | 52 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | T | 125 | 34x53 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | A | 118 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | A | 118 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM2 | M | 56 | 2x43 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM2 | M | 56 | 2x43 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM7 | T | 297 | 7x57 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM7 | T | 297 | 7x57 | G.H5 | V | 355 | G.H5.26 |
Polar | ICL2 | Q | 127 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Hydrophobic | ICL2 | Q | 127 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | Q | 127 | 34x55 | G.hns1 | R | 34 | G.hns1.03 |
Polar | ICL2 | N | 129 | 34x57 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | N | 129 | 34x57 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | N | 129 | 34x57 | G.hns1 | R | 33 | G.hns1.02 |
Polar | ICL3 | Q | 220 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL3 | Q | 220 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | Q | 220 | - | G.S6 | I | 320 | G.S6.01 |
Polar | ICL2 | P | 122 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM6 | M | 233 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | M | 233 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | TM7 | Y | 293 | 7x53 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | Y | 293 | 7x53 | G.H5 | N | 353 | G.H5.24 |
Polar | TM6 | R | 222 | 6x26 | G.h4s6 | K | 316 | G.h4s6.11 |
Hydrophobic | TM6 | R | 222 | 6x26 | G.h4s6 | K | 316 | G.h4s6.11 |
Van-der-waals | TM6 | R | 222 | 6x26 | G.h4s6 | K | 316 | G.h4s6.11 |
Hydrophobic | ICL2 | I | 123 | 34x51 | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | ICL2 | I | 123 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Van-der-waals | ICL2 | I | 123 | 34x51 | G.S3 | I | 195 | G.S3.01 |
Polar | TM7 | K | 298 | 7x58 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM7 | K | 298 | 7x58 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM7 | K | 298 | 7x58 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM7 | T | 297 | 7x57 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM7 | T | 297 | 7x57 | G.H5 | N | 353 | G.H5.24 |
Polar | TM6 | N | 223 | 6x27 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | N | 223 | 6x27 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | N | 223 | 6x27 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | V | 119 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 122 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Polar | TM3 | A | 118 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | A | 118 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | A | 118 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Polar | TM3 | R | 115 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM3 | R | 115 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM3 | N | 114 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | N | 114 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM5 | L | 213 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM5 | Q | 216 | 5x68 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM5 | Q | 216 | 5x68 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM6 | V | 226 | 6x30 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | V | 226 | 6x30 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM6 | A | 230 | 6x34 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | I | 123 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | ICL3 | Q | 220 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Van-der-waals | ICL3 | Q | 220 | - | G.h4s6 | V | 319 | G.h4s6.20 |
Polar | TM3 | R | 115 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 115 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 115 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | P | 122 | 34x50 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM3 | V | 119 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | R | 115 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL2 | A | 126 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | A | 126 | 34x54 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | I | 123 | 34x51 | G.H5 | I | 344 | G.H5.15 |