Gz - PTH1 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 79.7

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 14.7


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM3 I 310 3x58 G.H5 L 349 G.H5.20
Van-der-waals TM3 I 310 3x58 G.H5 L 349 G.H5.20
Hydrophobic TM6 L 413 6x45 G.H5 L 354 G.H5.25
Van-der-waals TM6 L 413 6x45 G.H5 L 354 G.H5.25
Hydrophobic ICL3 T 392 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 T 392 - G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 A 313 - G.H5 T 341 G.H5.12
Van-der-waals ICL2 A 313 - G.H5 T 341 G.H5.12
Hydrophobic TM3 L 306 3x54 G.H5 L 354 G.H5.25
Polar TM6 K 405 6x37 G.H5 C 355 G.H5.26
Hydrophobic TM6 K 405 6x37 G.H5 C 355 G.H5.26
Van-der-waals TM6 K 405 6x37 G.H5 C 355 G.H5.26
Hydrophobic ICL2 F 314 - G.S1 I 34 G.S1.02
Van-der-waals ICL2 F 314 - G.S1 I 34 G.S1.02
Hydrophobic ICL2 F 314 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 F 314 - G.H5 I 344 G.H5.15
Hydrophobic TM3 L 306 3x54 G.H5 I 352 G.H5.23
Van-der-waals TM3 L 306 3x54 G.H5 I 352 G.H5.23
Polar ICL3 N 393 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL3 N 393 - G.h4s6 E 319 G.h4s6.12
Van-der-waals ICL2 A 313 - G.H5 I 344 G.H5.15
Polar H8 E 465 8x49 G.H5 Y 351 G.H5.22
Hydrophobic H8 E 465 8x49 G.H5 Y 351 G.H5.22
Van-der-waals H8 E 465 8x49 G.H5 Y 351 G.H5.22
Hydrophobic TM6 V 412 6x44 G.H5 L 354 G.H5.25
Polar C-term S 504 - G.H3 N 258 G.H3.16
Van-der-waals C-term S 504 - G.H3 N 258 G.H3.16
Polar TM3 L 309 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 309 3x57 G.H5 N 348 G.H5.19
Van-der-waals TM3 L 309 3x57 G.H5 N 348 G.H5.19
Hydrophobic TM3 L 309 3x57 G.H5 I 352 G.H5.23
Van-der-waals TM3 L 309 3x57 G.H5 I 352 G.H5.23
Polar TM6 Q 401 6x33 G.h4s6 E 316 G.h4s6.09
Van-der-waals TM6 Q 401 6x33 G.h4s6 E 316 G.h4s6.09
Polar TM2 R 219 2x46 G.H5 Y 351 G.H5.22
Aromatic TM2 R 219 2x46 G.H5 Y 351 G.H5.22
Hydrophobic TM2 R 219 2x46 G.H5 Y 351 G.H5.22
Van-der-waals TM2 R 219 2x46 G.H5 Y 351 G.H5.22
Polar TM4 S 316 4x38 G.hns1 R 32 G.hns1.03
Van-der-waals TM4 S 316 4x38 G.hns1 R 32 G.hns1.03
Hydrophobic ICL2 F 314 - G.S3 L 195 G.S3.01
Van-der-waals ICL2 F 314 - G.S3 L 195 G.S3.01
Polar ICL3 N 393 - G.h4s6 K 315 G.h4s6.08
Hydrophobic ICL3 N 393 - G.h4s6 K 315 G.h4s6.08
Van-der-waals ICL3 N 393 - G.h4s6 K 315 G.h4s6.08
Polar TM4 K 318 4x40 G.HN Q 28 G.HN.52
Hydrophobic TM4 K 318 4x40 G.HN Q 28 G.HN.52
Van-der-waals TM4 K 318 4x40 G.HN Q 28 G.HN.52
Hydrophobic ICL2 F 314 - G.H5 F 337 G.H5.08
Van-der-waals ICL2 F 314 - G.H5 F 337 G.H5.08
Hydrophobic TM3 I 310 3x58 G.H5 I 345 G.H5.16
Van-der-waals TM3 I 310 3x58 G.H5 I 345 G.H5.16
Hydrophobic ICL2 F 314 - G.H5 T 341 G.H5.12
Hydrophobic TM5 L 385 5x61 G.H5 L 349 G.H5.20
Polar TM6 S 409 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM6 S 409 6x41 G.H5 L 354 G.H5.25
Van-der-waals TM6 S 409 6x41 G.H5 L 354 G.H5.25
Hydrophobic TM2 R 219 2x46 G.H5 I 352 G.H5.23
Ionic ICL3 R 396 - G.H4 D 310 G.H4.17
Polar ICL3 R 396 - G.H4 D 310 G.H4.17
Hydrophobic TM5 L 385 5x61 G.H5 L 354 G.H5.25
Hydrophobic TM5 L 385 5x61 G.H5 C 355 G.H5.26
Hydrophobic TM6 K 405 6x37 G.H5 L 354 G.H5.25
Polar TM2 C 217 2x44 G.H5 Y 351 G.H5.22
Hydrophobic TM2 C 217 2x44 G.H5 Y 351 G.H5.22
Van-der-waals TM2 C 217 2x44 G.H5 Y 351 G.H5.22
Ionic TM5 K 388 5x64 G.H5 D 342 G.H5.13
Polar TM5 K 388 5x64 G.H5 D 342 G.H5.13
Hydrophobic TM5 K 388 5x64 G.H5 D 342 G.H5.13
Van-der-waals TM5 K 388 5x64 G.H5 D 342 G.H5.13