G12 - PTH2 receptor complex model

GPCR CLASS (FAMILY)

B1 (Secretin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 73.0

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.4
PAE mean: 19.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term L 492 - H.HD E 172 H.HD.12
Aromatic ICL2 F 269 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 269 - G.H5 F 363 G.H5.08
Van-der-waals ICL2 F 269 - G.H5 F 363 G.H5.08
Hydrophobic TM3 I 265 3x58 G.H5 I 378 G.H5.23
Polar ICL2 S 271 - G.hns1 R 56 G.hns1.03
Hydrophobic ICL2 S 271 - G.hns1 R 56 G.hns1.03
Van-der-waals ICL2 S 271 - G.hns1 R 56 G.hns1.03
Polar TM6 K 363 6x40 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 363 6x40 G.H5 M 379 G.H5.24
Hydrophobic ICL2 F 269 - G.H5 I 370 G.H5.15
Hydrophobic ICL2 A 268 - G.H5 F 363 G.H5.08
Hydrophobic ICL2 F 269 - G.S3 I 221 G.S3.01
Van-der-waals ICL2 F 269 - G.S3 I 221 G.S3.01
Polar TM6 K 360 6x37 G.H5 Q 381 G.H5.26
Hydrophobic TM6 K 360 6x37 G.H5 Q 381 G.H5.26
Van-der-waals TM6 K 360 6x37 G.H5 Q 381 G.H5.26
Ionic TM2 R 176 2x46 G.H5 D 377 G.H5.22
Polar TM2 R 176 2x46 G.H5 D 377 G.H5.22
Hydrophobic TM2 R 176 2x46 G.H5 D 377 G.H5.22
Van-der-waals TM2 R 176 2x46 G.H5 D 377 G.H5.22
Hydrophobic ICL2 F 269 - G.H5 V 366 G.H5.11
Van-der-waals ICL2 F 269 - G.H5 V 366 G.H5.11
Hydrophobic TM3 L 261 3x54 G.H5 I 378 G.H5.23
Van-der-waals TM3 L 261 3x54 G.H5 I 378 G.H5.23
Ionic C-term H 489 - H.HD E 172 H.HD.12
Ionic C-term E 501 - G.hfs2 K 209 G.hfs2.06
Polar C-term E 501 - G.hfs2 K 209 G.hfs2.06
Hydrophobic C-term E 501 - G.hfs2 K 209 G.hfs2.06
Van-der-waals C-term E 501 - G.hfs2 K 209 G.hfs2.06
Polar TM6 K 363 6x40 G.H5 L 380 G.H5.25
Van-der-waals TM6 K 363 6x40 G.H5 L 380 G.H5.25
Hydrophobic TM7 I 412 7x56 G.H5 L 380 G.H5.25
Van-der-waals TM7 I 412 7x56 G.H5 L 380 G.H5.25
Polar C-term Y 495 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term Y 495 - G.s4h3 R 265 G.s4h3.12
Hydrophobic TM5 L 340 5x61 G.H5 M 379 G.H5.24
Van-der-waals TM5 L 340 5x61 G.H5 M 379 G.H5.24
Hydrophobic H8 N 417 8x47 G.H5 L 380 G.H5.25
Hydrophobic C-term L 492 - H.HA K 114 H.HA.28
Van-der-waals C-term L 492 - H.HA K 114 H.HA.28
Hydrophobic TM3 I 265 3x58 G.H5 L 371 G.H5.16
Hydrophobic TM6 L 368 6x45 G.H5 I 378 G.H5.23
Hydrophobic C-term L 492 - H.HA L 115 H.HA.29
Van-der-waals C-term L 492 - H.HA L 115 H.HA.29
Polar C-term P 493 - H.HA K 114 H.HA.28
Van-der-waals C-term P 493 - H.HA K 114 H.HA.28
Hydrophobic C-term Y 495 - H.hdhe Q 174 H.hdhe.02
Van-der-waals C-term Y 495 - H.hdhe Q 174 H.hdhe.02
Polar TM2 T 175 2x45 G.hns1 R 55 G.hns1.02
Hydrophobic TM7 C 416 7x60 G.H5 L 380 G.H5.25
Hydrophobic TM6 S 364 6x41 G.H5 M 379 G.H5.24
Van-der-waals TM6 S 364 6x41 G.H5 M 379 G.H5.24
Polar TM3 L 264 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM3 L 264 3x57 G.H5 N 374 G.H5.19
Van-der-waals TM3 L 264 3x57 G.H5 N 374 G.H5.19
Hydrophobic TM2 C 174 2x44 G.hns1 R 55 G.hns1.02
Hydrophobic TM5 V 339 5x60 G.H5 L 371 G.H5.16
Hydrophobic TM5 L 340 5x61 G.H5 L 375 G.H5.20
Hydrophobic C-term Y 495 - H.HA V 107 H.HA.21
Van-der-waals C-term Y 495 - H.HA V 107 H.HA.21
Ionic ICL1 R 170 12x48 G.HN D 44 G.HN.44
Polar ICL1 R 170 12x48 G.HN D 44 G.HN.44
Hydrophobic C-term P 493 - G.s4h3 R 265 G.s4h3.12
Van-der-waals C-term P 493 - G.s4h3 R 265 G.s4h3.12
Hydrophobic C-term W 497 - G.s4h3 M 262 G.s4h3.09
Hydrophobic TM3 I 265 3x58 G.H5 L 375 G.H5.20
Hydrophobic ICL2 A 268 - G.H5 K 367 G.H5.12
Van-der-waals ICL2 A 268 - G.H5 K 367 G.H5.12
Hydrophobic TM5 K 343 5x64 G.H5 L 371 G.H5.16
Van-der-waals TM5 K 343 5x64 G.H5 L 371 G.H5.16
Hydrophobic TM6 K 360 6x37 G.H5 M 379 G.H5.24
Van-der-waals TM6 K 360 6x37 G.H5 M 379 G.H5.24
Ionic ICL2 D 272 - G.hns1 R 55 G.hns1.02
Polar ICL2 D 272 - G.hns1 R 55 G.hns1.02
Hydrophobic ICL2 D 272 - G.hns1 R 55 G.hns1.02
Van-der-waals ICL2 D 272 - G.hns1 R 55 G.hns1.02
Polar ICL2 T 273 - G.HN R 52 G.HN.52
Hydrophobic ICL2 T 273 - G.HN R 52 G.HN.52
Van-der-waals ICL2 T 273 - G.HN R 52 G.HN.52
Hydrophobic C-term G 494 - H.hdhe F 173 H.hdhe.01
Hydrophobic ICL2 F 269 - G.S1 V 58 G.S1.02
Van-der-waals ICL2 F 269 - G.S1 V 58 G.S1.02
Polar C-term G 494 - H.HA K 114 H.HA.28
Hydrophobic C-term Y 495 - G.s4h3 M 262 G.s4h3.09
Ionic TM5 K 343 5x64 G.H5 D 368 G.H5.13
Polar TM5 K 343 5x64 G.H5 D 368 G.H5.13
Hydrophobic TM5 K 343 5x64 G.H5 D 368 G.H5.13
Van-der-waals TM5 K 343 5x64 G.H5 D 368 G.H5.13
Aromatic ICL2 F 269 - G.S3 F 223 G.S3.03
Hydrophobic ICL2 F 269 - G.S3 F 223 G.S3.03
Polar TM3 F 266 3x59 G.H5 K 367 G.H5.12
Hydrophobic TM3 F 266 3x59 G.H5 K 367 G.H5.12
Van-der-waals TM3 F 266 3x59 G.H5 K 367 G.H5.12