Gz -
QRFP receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 79.4
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.8
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | H8 | N | 338 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Hydrophobic | TM6 | A | 271 | 6x33 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM5 | R | 246 | 5x70 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM5 | R | 246 | 5x70 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | L | 400 | - | G.H3 | A | 245 | G.H3.03 |
Van-der-waals | C-term | L | 400 | - | G.H3 | A | 245 | G.H3.03 |
Polar | ICL2 | K | 154 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | K | 154 | 34x54 | G.S1 | E | 33 | G.S1.01 |
Hydrophobic | ICL2 | M | 153 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | M | 153 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Polar | H8 | N | 336 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | H8 | N | 336 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | H8 | N | 336 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Polar | ICL2 | Y | 157 | 34x57 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Y | 157 | 34x57 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | M | 153 | 34x53 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | ICL2 | M | 153 | 34x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM5 | V | 252 | 5x76 | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | TM5 | V | 252 | 5x76 | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | TM5 | V | 252 | 5x76 | G.S6 | H | 323 | G.S6.04 |
Van-der-waals | TM5 | V | 252 | 5x76 | G.S6 | H | 323 | G.S6.04 |
Hydrophobic | TM2 | T | 78 | 2x37 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | L | 400 | - | G.hgh4 | C | 287 | G.hgh4.01 |
Van-der-waals | C-term | L | 400 | - | G.hgh4 | C | 287 | G.hgh4.01 |
Hydrophobic | TM3 | L | 147 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | L | 147 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | A | 390 | - | G.H3 | S | 253 | G.H3.11 |
Polar | ICL2 | K | 154 | 34x54 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | K | 154 | 34x54 | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | ICL2 | K | 154 | 34x54 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM6 | K | 263 | 6x25 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | TM6 | K | 263 | 6x25 | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | TM5 | T | 255 | 5x79 | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | TM5 | T | 255 | 5x79 | G.H4 | Q | 305 | G.H4.12 |
Van-der-waals | TM5 | T | 255 | 5x79 | G.H4 | Q | 305 | G.H4.12 |
Hydrophobic | ICL2 | P | 150 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Polar | TM5 | R | 246 | 5x70 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM5 | R | 246 | 5x70 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | TM5 | R | 246 | 5x70 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | ICL3 | H | 257 | - | G.H4 | E | 309 | G.H4.16 |
Van-der-waals | ICL3 | H | 257 | - | G.H4 | E | 309 | G.H4.16 |
Hydrophobic | C-term | V | 398 | - | G.H3 | L | 248 | G.H3.06 |
Hydrophobic | TM6 | I | 264 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | ICL2 | W | 155 | 34x55 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | ICL2 | W | 155 | 34x55 | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | ICL2 | W | 155 | 34x55 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | ICL2 | F | 151 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | F | 151 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | F | 151 | 34x51 | G.s2s3 | K | 193 | G.s2s3.01 |
Hydrophobic | TM6 | M | 274 | 6x36 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM6 | M | 274 | 6x36 | G.H5 | G | 353 | G.H5.24 |
Ionic | C-term | E | 389 | - | G.H2 | K | 210 | G.H2.05 |
Polar | C-term | E | 389 | - | G.H2 | K | 210 | G.H2.05 |
Hydrophobic | C-term | E | 389 | - | G.H2 | K | 210 | G.H2.05 |
Van-der-waals | C-term | E | 389 | - | G.H2 | K | 210 | G.H2.05 |
Polar | ICL3 | E | 260 | - | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | ICL3 | E | 260 | - | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | TM6 | I | 264 | 6x26 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM5 | S | 251 | 5x75 | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | TM5 | S | 251 | 5x75 | G.H5 | F | 335 | G.H5.06 |
Ionic | TM6 | K | 267 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | K | 267 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | K | 267 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | K | 267 | 6x29 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | C-term | F | 391 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | F | 391 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | ICL2 | W | 155 | 34x55 | G.hns1 | R | 31 | G.hns1.02 |
Polar | C-term | I | 396 | - | G.H3 | R | 249 | G.H3.07 |
Hydrophobic | C-term | I | 396 | - | G.H3 | R | 249 | G.H3.07 |
Aromatic | ICL2 | W | 155 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | W | 155 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Van-der-waals | ICL2 | W | 155 | 34x55 | G.hns1 | R | 32 | G.hns1.03 |
Polar | TM2 | T | 80 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | TM2 | T | 80 | 2x39 | G.H5 | Y | 351 | G.H5.22 |
Polar | ICL2 | K | 154 | 34x54 | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | TM5 | V | 247 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | V | 247 | 5x71 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | C-term | L | 400 | - | G.s4h3 | S | 242 | G.s4h3.15 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | G | 353 | G.H5.24 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | C-term | I | 396 | - | G.H3 | D | 252 | G.H3.10 |
Van-der-waals | C-term | I | 396 | - | G.H3 | D | 252 | G.H3.10 |
Hydrophobic | ICL2 | F | 151 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | F | 151 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Polar | ICL2 | P | 150 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | P | 150 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | P | 150 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | C-term | C | 401 | - | G.hgh4 | P | 289 | G.hgh4.03 |
Van-der-waals | C-term | C | 401 | - | G.hgh4 | P | 289 | G.hgh4.03 |
Hydrophobic | TM5 | T | 255 | 5x79 | G.S6 | F | 324 | G.S6.05 |
Van-der-waals | TM5 | T | 255 | 5x79 | G.S6 | F | 324 | G.S6.05 |
Hydrophobic | C-term | L | 400 | - | G.H3 | L | 248 | G.H3.06 |
Polar | TM6 | K | 263 | 6x25 | G.h4s6 | K | 315 | G.h4s6.08 |
Hydrophobic | TM6 | K | 263 | 6x25 | G.h4s6 | K | 315 | G.h4s6.08 |
Van-der-waals | TM6 | K | 263 | 6x25 | G.h4s6 | K | 315 | G.h4s6.08 |
Polar | TM5 | G | 248 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | TM5 | G | 248 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Van-der-waals | TM5 | G | 248 | 5x72 | G.H5 | D | 338 | G.H5.09 |
Hydrophobic | ICL2 | M | 153 | 34x53 | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | ICL2 | M | 153 | 34x53 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM6 | M | 274 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | M | 274 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | ICL3 | E | 260 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | ICL3 | E | 260 | - | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM3 | E | 142 | 3x49 | G.H5 | I | 352 | G.H5.23 |
Polar | TM5 | T | 255 | 5x79 | G.S6 | S | 322 | G.S6.03 |
Ionic | TM5 | R | 246 | 5x70 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | R | 246 | 5x70 | G.H5 | D | 342 | G.H5.13 |
Polar | TM6 | A | 271 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | A | 271 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | A | 271 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | L | 147 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Polar | TM2 | V | 79 | 2x38 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | V | 79 | 2x38 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM5 | G | 248 | 5x72 | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | TM5 | L | 241 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Polar | ICL3 | H | 257 | - | G.H4 | R | 306 | G.H4.13 |
Hydrophobic | ICL3 | H | 257 | - | G.H4 | R | 306 | G.H4.13 |
Van-der-waals | ICL3 | H | 257 | - | G.H4 | R | 306 | G.H4.13 |
Hydrophobic | TM2 | T | 80 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM2 | T | 80 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | C-term | F | 391 | - | G.H3 | I | 254 | G.H3.12 |
Van-der-waals | C-term | F | 391 | - | G.H3 | I | 254 | G.H3.12 |
Hydrophobic | C-term | F | 391 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | TM3 | G | 146 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | G | 146 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Polar | TM6 | K | 267 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | TM6 | K | 267 | 6x29 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | C-term | F | 391 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | F | 391 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | TM6 | M | 275 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | M | 275 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | TM3 | G | 146 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | G | 146 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Ionic | ICL2 | K | 152 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | ICL2 | K | 152 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 152 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 152 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | P | 150 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | ICL2 | F | 151 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Van-der-waals | ICL2 | F | 151 | 34x51 | G.H5 | T | 341 | G.H5.12 |
Hydrophobic | TM4 | R | 160 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | R | 160 | 4x40 | G.HN | R | 24 | G.HN.48 |
Aromatic | C-term | F | 391 | - | G.H2 | W | 212 | G.H2.07 |
Hydrophobic | C-term | F | 391 | - | G.H2 | W | 212 | G.H2.07 |
Van-der-waals | C-term | F | 391 | - | G.H2 | W | 212 | G.H2.07 |