GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | S | 190 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | S | 190 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | ICL2 | S | 190 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Hydrophobic | ICL2 | L | 188 | - | G.H5 | I | 344 | G.H5.16 |
Polar | C-term | P | 449 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | ICL2 | K | 189 | - | G.s2s3 | D | 193 | G.s2s3.02 |
Van-der-waals | C-term | P | 450 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | ICL2 | L | 188 | - | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | L | 188 | - | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | C-term | Y | 455 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Van-der-waals | C-term | Y | 455 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Hydrophobic | C-term | P | 450 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Van-der-waals | C-term | P | 450 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | TM3 | V | 184 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM3 | R | 180 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | Y | 448 | - | G.H3 | S | 252 | G.H3.11 |
Ionic | TM6 | R | 320 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | R | 320 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | R | 320 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | R | 320 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Ionic | ICL2 | R | 204 | - | G.HN | E | 18 | G.HN.42 |
Polar | ICL2 | R | 204 | - | G.HN | E | 18 | G.HN.42 |
Hydrophobic | ICL2 | R | 204 | - | G.HN | E | 18 | G.HN.42 |
Van-der-waals | ICL2 | R | 204 | - | G.HN | E | 18 | G.HN.42 |
Hydrophobic | C-term | L | 445 | - | G.H3 | N | 255 | G.H3.14 |
Polar | TM6 | R | 320 | 6x29 | G.S6 | Y | 320 | G.S6.02 |
Aromatic | C-term | Y | 460 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | C-term | Y | 460 | - | G.H3 | H | 244 | G.H3.03 |
Polar | C-term | Y | 447 | - | G.h4s6 | R | 313 | G.h4s6.04 |
Hydrophobic | C-term | V | 453 | - | G.H3 | L | 249 | G.H3.08 |
Hydrophobic | TM6 | V | 328 | 6x37 | G.H5 | L | 353 | G.H5.25 |
Ionic | H8 | R | 394 | 8x48 | G.h4s6 | D | 315 | G.h4s6.09 |
Van-der-waals | ICL2 | H | 191 | - | G.hns1 | K | 32 | G.hns1.03 |
Polar | H8 | R | 393 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | H8 | R | 393 | 8x47 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM6 | A | 316 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | A | 316 | 6x25 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | L | 188 | - | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | L | 206 | - | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | TM5 | I | 294 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Ionic | TM6 | R | 320 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | R | 320 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | R | 320 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | R | 320 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM5 | R | 297 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | K | 189 | - | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 189 | - | G.hns1 | K | 32 | G.hns1.03 |
Polar | C-term | Y | 447 | - | G.H3 | K | 257 | G.H3.16 |
Aromatic | C-term | Y | 447 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | C-term | Y | 447 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | Y | 447 | - | G.H3 | K | 257 | G.H3.16 |
Polar | C-term | Y | 455 | - | G.H3 | E | 245 | G.H3.04 |
Van-der-waals | C-term | Y | 455 | - | G.H3 | E | 245 | G.H3.04 |
Hydrophobic | C-term | L | 445 | - | G.h4s6 | M | 312 | G.h4s6.03 |
Van-der-waals | C-term | L | 445 | - | G.h4s6 | M | 312 | G.h4s6.03 |
Hydrophobic | C-term | L | 463 | - | G.H3 | L | 247 | G.H3.06 |
Van-der-waals | C-term | L | 463 | - | G.H3 | L | 247 | G.H3.06 |
Hydrophobic | C-term | L | 463 | - | G.H3 | N | 251 | G.H3.10 |
Aromatic | C-term | Y | 447 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | Y | 447 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | Y | 447 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | TM6 | S | 327 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | S | 183 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | S | 183 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | G | 451 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | ICL2 | A | 187 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | G | 451 | - | G.H3 | L | 249 | G.H3.08 |
Van-der-waals | C-term | G | 451 | - | G.H3 | L | 249 | G.H3.08 |
Hydrophobic | ICL3 | G | 311 | - | G.H4 | K | 304 | G.H4.12 |
Van-der-waals | ICL3 | G | 311 | - | G.H4 | K | 304 | G.H4.12 |
Hydrophobic | ICL2 | S | 205 | - | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | ICL2 | S | 205 | - | G.HN | Q | 24 | G.HN.48 |
Polar | ICL2 | C | 201 | - | G.HN | K | 21 | G.HN.45 |
Van-der-waals | ICL2 | C | 201 | - | G.HN | K | 21 | G.HN.45 |
Hydrophobic | C-term | P | 464 | - | G.h4s6 | M | 312 | G.h4s6.03 |
Van-der-waals | C-term | P | 464 | - | G.h4s6 | M | 312 | G.h4s6.03 |
Hydrophobic | H8 | R | 393 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Polar | C-term | Y | 460 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | Y | 460 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Polar | C-term | Y | 460 | - | G.s4h3 | N | 241 | G.s4h3.15 |
Hydrophobic | TM5 | L | 290 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM5 | L | 290 | 5x61 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | Y | 447 | - | G.H3 | N | 255 | G.H3.14 |
Van-der-waals | C-term | Y | 447 | - | G.H3 | N | 255 | G.H3.14 |
Hydrophobic | ICL3 | P | 313 | - | G.S6 | Y | 320 | G.S6.02 |
Polar | TM3 | S | 183 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | S | 183 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | S | 183 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | V | 184 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM2 | I | 117 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | I | 117 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Polar | ICL2 | R | 204 | - | G.HN | E | 25 | G.HN.49 |
Hydrophobic | ICL2 | R | 204 | - | G.HN | E | 25 | G.HN.49 |
Van-der-waals | ICL2 | R | 204 | - | G.HN | E | 25 | G.HN.49 |
Hydrophobic | C-term | L | 463 | - | G.h4s6 | L | 310 | G.h4s6.01 |
Polar | ICL2 | G | 207 | - | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | ICL2 | G | 207 | - | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | ICL2 | G | 207 | - | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | C-term | V | 453 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | ICL2 | R | 204 | - | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | ICL2 | R | 204 | - | G.HN | Q | 24 | G.HN.48 |
Polar | C-term | Y | 448 | - | G.H3 | H | 256 | G.H3.15 |
Polar | ICL2 | D | 208 | - | G.HN | Q | 24 | G.HN.48 |
Van-der-waals | ICL2 | D | 208 | - | G.HN | Q | 24 | G.HN.48 |
Polar | ICL2 | G | 207 | - | G.HN | D | 28 | G.HN.52 |
Hydrophobic | TM5 | F | 293 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | R | 320 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | R | 320 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | C-term | P | 450 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | C-term | L | 463 | - | G.H3 | H | 248 | G.H3.07 |
Polar | ICL2 | R | 204 | - | G.HN | K | 17 | G.HN.41 |
Hydrophobic | ICL2 | R | 204 | - | G.HN | K | 17 | G.HN.41 |
Van-der-waals | ICL2 | R | 204 | - | G.HN | K | 17 | G.HN.41 |
Hydrophobic | ICL2 | L | 188 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | V | 453 | - | G.H3 | E | 245 | G.H3.04 |
Van-der-waals | C-term | V | 453 | - | G.H3 | E | 245 | G.H3.04 |
Polar | TM5 | R | 297 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM5 | R | 297 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | TM5 | R | 297 | 5x68 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | V | 184 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | G | 203 | - | G.HN | E | 25 | G.HN.49 |
Van-der-waals | ICL2 | G | 203 | - | G.HN | E | 25 | G.HN.49 |
Polar | TM3 | R | 180 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | R | 320 | 6x29 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | A | 187 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | A | 187 | - | G.H5 | N | 347 | G.H5.19 |
Polar | C-term | Y | 455 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | C-term | Y | 455 | - | G.H2 | R | 205 | G.H2.01 |
Van-der-waals | C-term | Y | 455 | - | G.H2 | R | 205 | G.H2.01 |
Hydrophobic | C-term | V | 453 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | V | 453 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | ICL2 | R | 204 | - | G.HN | K | 21 | G.HN.45 |
Van-der-waals | ICL2 | R | 204 | - | G.HN | K | 21 | G.HN.45 |
Hydrophobic | TM6 | V | 324 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM6 | V | 324 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | P | 450 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | P | 450 | - | G.H3 | H | 256 | G.H3.15 |
Polar | TM3 | R | 180 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 180 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 180 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM6 | V | 324 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Aromatic | TM6 | K | 323 | 6x32 | G.H5 | F | 354 | G.H5.26 |
Polar | TM5 | G | 304 | 5x75 | G.H5 | K | 333 | G.H5.05 |
Hydrophobic | TM5 | G | 304 | 5x75 | G.H5 | K | 333 | G.H5.05 |
Van-der-waals | TM5 | G | 304 | 5x75 | G.H5 | K | 333 | G.H5.05 |
Polar | C-term | G | 451 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | G | 451 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | G | 451 | - | G.H2 | R | 208 | G.H2.04 |
Polar | C-term | G | 451 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | G | 451 | - | G.H3 | S | 252 | G.H3.11 |
Hydrophobic | TM5 | Y | 287 | 5x58 | G.H5 | L | 353 | G.H5.25 |