G13 - S1P1 receptor complex model

GPCR CLASS (FAMILY)

A (Rhodopsin)

SPECIES

Homo sapiens

G PROTEIN FAMILY

G12/13

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 84.2

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.8
iPTM Score: 0.7
PAE mean: 14.8


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, Gβ, Gγ, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Polar C-term S 353 - G.H2 K 231 G.H2.05
Hydrophobic C-term S 353 - G.H2 K 231 G.H2.05
Van-der-waals C-term S 353 - G.H2 K 231 G.H2.05
Ionic ICL3 K 239 - G.H5 D 361 G.H5.10
Polar ICL3 K 239 - G.H5 D 361 G.H5.10
Hydrophobic ICL3 K 239 - G.H5 D 361 G.H5.10
Van-der-waals ICL3 K 239 - G.H5 D 361 G.H5.10
Ionic C-term E 349 - G.H3 R 279 G.H3.16
Polar C-term E 349 - G.H3 R 279 G.H3.16
Hydrophobic C-term E 349 - G.H3 R 279 G.H3.16
Van-der-waals C-term E 349 - G.H3 R 279 G.H3.16
Van-der-waals TM3 R 142 3x50 G.H5 L 376 G.H5.25
Hydrophobic ICL3 K 239 - G.H5 R 360 G.H5.09
Hydrophobic ICL3 K 239 - G.S6 Y 343 G.S6.02
Van-der-waals ICL3 K 239 - G.S6 Y 343 G.S6.02
Hydrophobic ICL2 L 151 34x52 G.S1 L 48 G.S1.01
Van-der-waals ICL2 L 151 34x52 G.S1 L 48 G.S1.01
Hydrophobic TM1 W 71 1x58 G.HN M 1 G.HN.01
Van-der-waals TM1 W 71 1x58 G.HN M 1 G.HN.01
Hydrophobic ICL2 K 150 34x51 G.H5 I 366 G.H5.15
Hydrophobic ICL2 L 151 34x52 G.h2s4 T 241 G.h2s4.05
Van-der-waals ICL2 L 151 34x52 G.h2s4 T 241 G.h2s4.05
Hydrophobic TM5 L 235 5x72 G.H5 D 364 G.H5.13
Ionic ICL3 K 239 - G.H5 D 364 G.H5.13
Polar ICL3 K 239 - G.H5 D 364 G.H5.13
Van-der-waals ICL3 K 239 - G.H5 D 364 G.H5.13
Hydrophobic ICL2 L 151 34x52 G.H5 I 366 G.H5.15
Van-der-waals ICL2 L 151 34x52 G.H5 I 366 G.H5.15
Polar ICL2 K 150 34x51 G.H5 N 370 G.H5.19
Van-der-waals ICL2 K 150 34x51 G.H5 N 370 G.H5.19
Hydrophobic TM5 S 232 5x69 G.H5 L 367 G.H5.16
Hydrophobic TM7 Y 311 7x53 G.H5 L 376 G.H5.25
Ionic C-term H 360 - G.s4h3 D 259 G.s4h3.11
Polar C-term H 360 - G.s4h3 D 259 G.s4h3.11
Hydrophobic C-term H 360 - G.s4h3 D 259 G.s4h3.11
Van-der-waals C-term H 360 - G.s4h3 D 259 G.s4h3.11
Hydrophobic TM3 M 146 3x54 G.H5 L 367 G.H5.16
Van-der-waals TM3 M 146 3x54 G.H5 L 367 G.H5.16
Polar TM3 R 142 3x50 G.H5 L 374 G.H5.23
Hydrophobic TM3 R 142 3x50 G.H5 L 374 G.H5.23
Van-der-waals TM3 R 142 3x50 G.H5 L 374 G.H5.23
Polar ICL2 G 154 34x55 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 G 154 34x55 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 G 154 34x55 G.hns1 K 46 G.hns1.02
Polar ICL3 R 238 - G.H5 R 360 G.H5.09
Van-der-waals ICL3 R 238 - G.H5 R 360 G.H5.09
Hydrophobic TM5 L 235 5x72 G.H5 L 367 G.H5.16
Hydrophobic TM3 M 146 3x54 G.H5 N 370 G.H5.19
Hydrophobic TM6 A 253 6x32 G.H5 M 375 G.H5.24
Van-der-waals TM6 A 253 6x32 G.H5 M 375 G.H5.24
Polar ICL3 K 243 - G.S6 H 344 G.S6.03
Aromatic ICL3 K 243 - G.S6 H 344 G.S6.03
Hydrophobic ICL3 K 243 - G.S6 H 344 G.S6.03
Van-der-waals ICL3 K 243 - G.S6 H 344 G.S6.03
Hydrophobic TM2 I 84 2x43 G.H5 L 376 G.H5.25
Van-der-waals TM2 I 84 2x43 G.H5 L 376 G.H5.25
Hydrophobic ICL2 M 149 34x50 G.H5 K 363 G.H5.12
Van-der-waals ICL2 M 149 34x50 G.H5 K 363 G.H5.12
Polar ICL2 N 153 34x54 G.H5 Q 373 G.H5.22
Hydrophobic ICL2 N 153 34x54 G.H5 Q 373 G.H5.22
Van-der-waals ICL2 N 153 34x54 G.H5 Q 373 G.H5.22
Hydrophobic ICL2 L 151 34x52 G.S1 V 49 G.S1.02
Hydrophobic TM5 R 231 5x68 G.H5 L 367 G.H5.16
Hydrophobic TM6 L 254 6x33 G.H5 M 375 G.H5.24
Van-der-waals TM6 L 254 6x33 G.H5 M 375 G.H5.24
Hydrophobic ICL2 M 149 34x50 G.H5 N 370 G.H5.19
Hydrophobic TM6 L 254 6x33 G.H5 L 371 G.H5.20
Aromatic C-term F 350 - G.H3 R 279 G.H3.16
Polar C-term S 351 - G.H2 K 231 G.H2.05
Hydrophobic TM5 L 235 5x72 G.H5 R 360 G.H5.09
Van-der-waals TM5 L 235 5x72 G.H5 R 360 G.H5.09
Polar H8 N 315 8x47 G.H5 L 376 G.H5.25
Hydrophobic H8 N 315 8x47 G.H5 L 376 G.H5.25
Van-der-waals H8 N 315 8x47 G.H5 L 376 G.H5.25
Hydrophobic ICL2 M 149 34x50 G.H5 I 366 G.H5.15
Hydrophobic TM2 M 80 2x39 G.H5 L 376 G.H5.25
Hydrophobic TM6 L 254 6x33 G.H5 L 374 G.H5.23
Van-der-waals TM6 L 254 6x33 G.H5 L 374 G.H5.23
Polar C-term G 347 - G.H3 R 279 G.H3.16
Hydrophobic C-term G 347 - G.H3 R 279 G.H3.16
Van-der-waals C-term G 347 - G.H3 R 279 G.H3.16
Hydrophobic TM3 M 146 3x54 G.H5 L 374 G.H5.23
Van-der-waals TM3 M 146 3x54 G.H5 L 374 G.H5.23
Polar H8 K 316 8x48 G.H5 L 376 G.H5.25
Hydrophobic TM5 I 224 5x61 G.H5 L 374 G.H5.23
Hydrophobic TM5 L 235 5x72 G.H5 K 363 G.H5.12
Hydrophobic TM2 Y 81 2x40 G.H5 L 376 G.H5.25
Hydrophobic TM5 V 228 5x65 G.H5 L 371 G.H5.20
Van-der-waals TM5 V 228 5x65 G.H5 L 371 G.H5.20
Hydrophobic ICL2 M 149 34x50 G.H5 L 367 G.H5.16
Polar TM6 K 250 6x29 G.H5 H 368 G.H5.17
Aromatic TM6 K 250 6x29 G.H5 H 368 G.H5.17
Hydrophobic TM6 K 250 6x29 G.H5 H 368 G.H5.17
Van-der-waals TM6 K 250 6x29 G.H5 H 368 G.H5.17
Polar ICL2 H 152 34x53 G.hns1 V 45 G.hns1.01
Hydrophobic C-term M 348 - G.H3 R 279 G.H3.16
Van-der-waals C-term M 348 - G.H3 R 279 G.H3.16
Polar ICL2 H 152 34x53 G.hns1 K 46 G.hns1.02
Hydrophobic ICL2 H 152 34x53 G.hns1 K 46 G.hns1.02
Van-der-waals ICL2 H 152 34x53 G.hns1 K 46 G.hns1.02