Ggust -
S1P1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 82.2
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 13.3
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | H | 152 | 34x53 | G.hns1 | D | 30 | G.hns1.01 |
Van-der-waals | ICL2 | H | 152 | 34x53 | G.hns1 | D | 30 | G.hns1.01 |
Polar | H8 | K | 316 | 8x48 | G.H5 | F | 354 | G.H5.26 |
Polar | ICL3 | R | 238 | - | G.H5 | Q | 330 | G.H5.02 |
Hydrophobic | ICL3 | R | 238 | - | G.H5 | Q | 330 | G.H5.02 |
Van-der-waals | ICL3 | R | 238 | - | G.H5 | Q | 330 | G.H5.02 |
Hydrophobic | TM5 | R | 231 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | R | 231 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | C-term | F | 350 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Hydrophobic | TM6 | K | 250 | 6x29 | G.H5 | F | 354 | G.H5.26 |
Polar | ICL2 | H | 152 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | H | 152 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | H | 152 | 34x53 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | TM2 | M | 80 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | M | 80 | 2x39 | G.H5 | D | 350 | G.H5.22 |
Polar | TM6 | R | 246 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | TM6 | R | 246 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Van-der-waals | TM6 | R | 246 | 6x25 | G.h4s6 | K | 314 | G.h4s6.08 |
Hydrophobic | C-term | F | 350 | - | G.H3 | L | 249 | G.H3.08 |
Van-der-waals | C-term | F | 350 | - | G.H3 | L | 249 | G.H3.08 |
Polar | TM7 | T | 314 | 7x56 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM7 | T | 314 | 7x56 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM3 | T | 145 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | T | 145 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | V | 228 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Polar | TM6 | R | 246 | 6x25 | G.h4s6 | K | 317 | G.h4s6.11 |
Polar | ICL3 | K | 243 | - | G.S6 | I | 319 | G.S6.01 |
Van-der-waals | ICL3 | K | 243 | - | G.S6 | I | 319 | G.S6.01 |
Hydrophobic | H8 | N | 315 | 8x47 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | K | 150 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | C-term | R | 352 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Van-der-waals | C-term | R | 352 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Hydrophobic | ICL2 | K | 150 | 34x51 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | K | 150 | 34x51 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL3 | R | 238 | - | G.H5 | K | 333 | G.H5.05 |
Van-der-waals | ICL3 | R | 238 | - | G.H5 | K | 333 | G.H5.05 |
Polar | ICL2 | K | 150 | 34x51 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | K | 150 | 34x51 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | L | 235 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | L | 235 | 5x72 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | V | 228 | 5x65 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM4 | N | 156 | 4x38 | G.HN | Q | 24 | G.HN.48 |
Hydrophobic | ICL2 | M | 149 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | M | 149 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Ionic | ICL2 | K | 150 | 34x51 | G.HN | E | 28 | G.HN.52 |
Polar | ICL2 | K | 150 | 34x51 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | K | 150 | 34x51 | G.HN | E | 28 | G.HN.52 |
Ionic | TM6 | K | 250 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 250 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | K | 250 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 250 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM2 | M | 80 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | M | 80 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | M | 348 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | M | 348 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | TM3 | R | 142 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 142 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL2 | M | 149 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | C-term | F | 350 | - | G.H3 | I | 253 | G.H3.12 |
Van-der-waals | C-term | F | 350 | - | G.H3 | I | 253 | G.H3.12 |
Polar | TM3 | R | 142 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 142 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 142 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Ionic | TM6 | K | 250 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Polar | TM6 | K | 250 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | K | 250 | 6x29 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM3 | M | 146 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | M | 146 | 3x54 | G.H5 | N | 347 | G.H5.19 |
Ionic | TM2 | R | 78 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Polar | TM2 | R | 78 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | R | 78 | 2x37 | G.H5 | D | 350 | G.H5.22 |
Ionic | H8 | E | 317 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Polar | H8 | E | 317 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | H8 | E | 317 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | H8 | E | 317 | 8x49 | G.H5 | K | 349 | G.H5.21 |
Polar | ICL2 | L | 151 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | L | 151 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | L | 151 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Ionic | TM3 | K | 148 | 3x56 | G.HN | E | 28 | G.HN.52 |
Hydrophobic | C-term | M | 348 | - | G.H2 | K | 209 | G.H2.05 |
Polar | ICL2 | N | 153 | 34x54 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | N | 153 | 34x54 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL2 | N | 153 | 34x54 | G.H5 | D | 350 | G.H5.22 |
Polar | TM3 | R | 142 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | ICL2 | L | 151 | 34x52 | G.S1 | V | 34 | G.S1.02 |
Van-der-waals | ICL2 | L | 151 | 34x52 | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | ICL2 | L | 151 | 34x52 | G.h2s4 | T | 219 | G.h2s4.05 |
Van-der-waals | ICL2 | L | 151 | 34x52 | G.h2s4 | T | 219 | G.h2s4.05 |
Hydrophobic | TM3 | M | 146 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Aromatic | C-term | F | 350 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | C-term | F | 350 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | F | 350 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | TM3 | T | 145 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | T | 145 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM6 | K | 250 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Hydrophobic | TM5 | L | 235 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | TM5 | L | 235 | 5x72 | G.H5 | D | 337 | G.H5.09 |
Van-der-waals | ICL3 | K | 243 | - | G.H4 | L | 308 | G.H4.16 |
Hydrophobic | ICL2 | L | 151 | 34x52 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 151 | 34x52 | G.H5 | I | 343 | G.H5.15 |
Polar | C-term | F | 350 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | F | 350 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | F | 350 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | TM3 | M | 146 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Ionic | C-term | R | 352 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Hydrophobic | TM6 | L | 254 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Polar | TM7 | T | 314 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM5 | L | 235 | 5x72 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | TM3 | M | 146 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | M | 146 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | TM6 | L | 254 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 254 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | ICL3 | K | 239 | - | G.S6 | Y | 320 | G.S6.02 |
Van-der-waals | ICL3 | K | 239 | - | G.S6 | Y | 320 | G.S6.02 |
Hydrophobic | ICL3 | K | 239 | - | G.S6 | H | 322 | G.S6.04 |
Ionic | ICL3 | K | 239 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | K | 239 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | T | 257 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 257 | 6x36 | G.H5 | L | 353 | G.H5.25 |