Gi3 -
S1P2 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.6
PAE mean: 14.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | K | 138 | 34x51 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | V | 137 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | V | 137 | 34x50 | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | TM6 | Q | 227 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Van-der-waals | TM6 | Q | 227 | 6x29 | G.H5 | K | 345 | G.H5.17 |
Polar | TM7 | R | 291 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM7 | R | 291 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM7 | R | 291 | 7x56 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM3 | I | 134 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Van-der-waals | TM3 | I | 134 | 3x54 | G.H5 | L | 348 | G.H5.20 |
Polar | ICL2 | L | 139 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | L | 139 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | L | 139 | 34x52 | G.hns1 | A | 31 | G.hns1.02 |
Polar | TM3 | A | 133 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM3 | A | 133 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | TM3 | A | 133 | 3x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | TM5 | Y | 209 | 5x58 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM3 | A | 133 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 130 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | R | 130 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM2 | M | 68 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM2 | M | 68 | 2x39 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | ICL2 | L | 139 | 34x52 | G.H5 | I | 343 | G.H5.15 |
Polar | TM6 | L | 231 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | L | 231 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | L | 231 | 6x33 | G.H5 | L | 353 | G.H5.25 |
Ionic | ICL3 | H | 220 | - | G.H5 | D | 341 | G.H5.13 |
Polar | ICL3 | H | 220 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL3 | H | 220 | - | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | ICL3 | H | 220 | - | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | ICL2 | Y | 140 | 34x53 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM7 | R | 291 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Van-der-waals | TM7 | R | 291 | 7x56 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | A | 230 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | A | 230 | 6x32 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | C-term | M | 340 | - | G.H2 | H | 213 | G.H2.09 |
Van-der-waals | C-term | M | 340 | - | G.H2 | H | 213 | G.H2.09 |
Hydrophobic | ICL2 | L | 139 | 34x52 | G.S1 | E | 33 | G.S1.01 |
Van-der-waals | ICL2 | L | 139 | 34x52 | G.S1 | E | 33 | G.S1.01 |
Ionic | ICL2 | D | 143 | 34x56 | G.HN | R | 24 | G.HN.48 |
Polar | ICL2 | D | 143 | 34x56 | G.HN | R | 24 | G.HN.48 |
Hydrophobic | ICL2 | D | 143 | 34x56 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | ICL2 | D | 143 | 34x56 | G.HN | R | 24 | G.HN.48 |
Polar | TM6 | T | 234 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 234 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 234 | 6x36 | G.H5 | L | 353 | G.H5.25 |
Polar | TM3 | R | 130 | 3x50 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM5 | V | 216 | 5x65 | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | ICL2 | L | 139 | 34x52 | G.S1 | V | 34 | G.S1.02 |
Hydrophobic | ICL3 | M | 223 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | ICL3 | M | 223 | - | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | Q | 227 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | Q | 227 | 6x29 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | V | 137 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Van-der-waals | ICL2 | V | 137 | 34x50 | G.H5 | T | 340 | G.H5.12 |
Hydrophobic | ICL2 | G | 141 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | G | 141 | 34x54 | G.hns1 | A | 31 | G.hns1.02 |
Polar | ICL2 | Y | 140 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | Y | 140 | 34x53 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | V | 137 | 34x50 | G.S3 | L | 194 | G.S3.01 |
Hydrophobic | ICL2 | L | 139 | 34x52 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | ICL2 | D | 143 | 34x56 | G.HN | E | 28 | G.HN.52 |
Van-der-waals | ICL2 | D | 143 | 34x56 | G.HN | E | 28 | G.HN.52 |
Polar | TM6 | Q | 227 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Hydrophobic | TM6 | Q | 227 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Van-der-waals | TM6 | Q | 227 | 6x29 | G.H5 | Y | 354 | G.H5.26 |
Polar | TM5 | S | 219 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM5 | S | 219 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM5 | S | 219 | 5x68 | G.H5 | D | 341 | G.H5.13 |
Polar | ICL2 | S | 142 | 34x55 | G.HN | G | 27 | G.HN.51 |
Hydrophobic | ICL2 | S | 142 | 34x55 | G.HN | G | 27 | G.HN.51 |
Polar | TM6 | A | 224 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | A | 224 | 6x26 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | ICL2 | K | 138 | 34x51 | G.hns1 | K | 32 | G.hns1.03 |
Van-der-waals | ICL2 | K | 138 | 34x51 | G.hns1 | K | 32 | G.hns1.03 |
Hydrophobic | TM3 | I | 134 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | V | 352 | - | H.hbhc | E | 115 | H.hbhc.03 |
Van-der-waals | C-term | V | 352 | - | H.hbhc | E | 115 | H.hbhc.03 |
Hydrophobic | TM5 | S | 219 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Van-der-waals | TM5 | S | 219 | 5x68 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | L | 231 | 6x33 | G.H5 | L | 348 | G.H5.20 |
Ionic | C-term | E | 335 | - | G.H2 | K | 209 | G.H2.05 |
Polar | C-term | E | 335 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | E | 335 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | E | 335 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | TM5 | V | 215 | 5x64 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM2 | M | 68 | 2x39 | G.H5 | E | 350 | G.H5.22 |
Polar | TM3 | R | 130 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | R | 130 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | R | 130 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM4 | C | 146 | 4x40 | G.HN | R | 24 | G.HN.48 |
Van-der-waals | TM4 | C | 146 | 4x40 | G.HN | R | 24 | G.HN.48 |
Polar | ICL2 | K | 138 | 34x51 | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | K | 138 | 34x51 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | Y | 140 | 34x53 | G.H5 | E | 350 | G.H5.22 |
Van-der-waals | ICL2 | Y | 140 | 34x53 | G.H5 | E | 350 | G.H5.22 |
Hydrophobic | TM3 | I | 134 | 3x54 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM5 | V | 216 | 5x65 | G.H5 | I | 344 | G.H5.16 |