G14 -
S1P3 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.3
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.6
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM7 | A | 301 | 7x56 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM7 | A | 301 | 7x56 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | ICL2 | P | 145 | 34x52 | G.S1 | L | 36 | G.S1.02 |
Hydrophobic | TM5 | L | 221 | 5x64 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM5 | L | 221 | 5x64 | G.H5 | L | 345 | G.H5.16 |
Hydrophobic | TM3 | M | 140 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | M | 140 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | ICL2 | R | 144 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | R | 144 | 34x51 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM5 | K | 228 | 5x71 | G.H5 | A | 338 | G.H5.09 |
Hydrophobic | TM3 | T | 139 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | T | 139 | 3x53 | G.H5 | F | 352 | G.H5.23 |
Polar | TM5 | S | 225 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | S | 225 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | S | 225 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | ICL3 | V | 229 | - | G.H5 | A | 338 | G.H5.09 |
Van-der-waals | ICL3 | V | 229 | - | G.H5 | A | 338 | G.H5.09 |
Polar | TM6 | T | 244 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | T | 244 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | T | 244 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | V | 245 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | V | 245 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | R | 136 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 136 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Polar | H8 | S | 302 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | H8 | S | 302 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | H8 | S | 302 | 8x47 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM3 | M | 140 | 3x54 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | M | 140 | 3x54 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM5 | V | 222 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM5 | S | 225 | 5x68 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM5 | S | 225 | 5x68 | G.H5 | L | 345 | G.H5.16 |
Polar | TM6 | N | 234 | 6x26 | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | ICL3 | V | 229 | - | G.H5 | A | 339 | G.H5.10 |
Ionic | TM6 | R | 237 | 6x29 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | TM6 | R | 237 | 6x29 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | TM6 | R | 237 | 6x29 | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | TM6 | R | 237 | 6x29 | G.h4s6 | E | 317 | G.h4s6.12 |
Hydrophobic | TM3 | E | 135 | 3x49 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM6 | L | 241 | 6x33 | G.H5 | V | 355 | G.H5.26 |
Van-der-waals | TM6 | L | 241 | 6x33 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | TM6 | L | 241 | 6x33 | G.H5 | R | 350 | G.H5.21 |
Hydrophobic | ICL3 | V | 229 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | V | 229 | - | G.S6 | Y | 321 | G.S6.02 |
Polar | ICL2 | R | 144 | 34x51 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | R | 144 | 34x51 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | R | 144 | 34x51 | G.hns1 | R | 33 | G.hns1.02 |
Polar | TM3 | R | 136 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 136 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM3 | R | 136 | 3x50 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL3 | V | 229 | - | G.H5 | F | 335 | G.H5.06 |
Van-der-waals | ICL3 | V | 229 | - | G.H5 | F | 335 | G.H5.06 |
Hydrophobic | TM6 | L | 241 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | L | 241 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Polar | TM2 | Y | 75 | 2x40 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM2 | Y | 75 | 2x40 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM2 | Y | 75 | 2x40 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | ICL3 | V | 229 | - | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | L | 241 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | N | 234 | 6x26 | G.h4s6 | V | 319 | G.h4s6.20 |
Van-der-waals | TM6 | N | 234 | 6x26 | G.h4s6 | V | 319 | G.h4s6.20 |
Ionic | H8 | K | 303 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | H8 | K | 303 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |
Van-der-waals | H8 | K | 303 | 8x48 | G.h4s6 | E | 317 | G.h4s6.12 |
Polar | TM6 | T | 244 | 6x36 | G.H5 | V | 355 | G.H5.26 |
Hydrophobic | ICL2 | R | 144 | 34x51 | G.hns1 | R | 34 | G.hns1.03 |
Van-der-waals | ICL2 | R | 144 | 34x51 | G.hns1 | R | 34 | G.hns1.03 |
Aromatic | ICL2 | Y | 146 | 34x53 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | Y | 146 | 34x53 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | ICL2 | Y | 146 | 34x53 | G.H5 | F | 352 | G.H5.23 |
Ionic | ICL2 | D | 147 | 34x54 | G.hns1 | R | 33 | G.hns1.02 |
Polar | ICL2 | D | 147 | 34x54 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | D | 147 | 34x54 | G.hns1 | R | 33 | G.hns1.02 |
Van-der-waals | ICL2 | D | 147 | 34x54 | G.hns1 | R | 33 | G.hns1.02 |
Polar | ICL2 | R | 144 | 34x51 | G.HN | K | 30 | G.HN.52 |
Van-der-waals | ICL2 | R | 144 | 34x51 | G.HN | K | 30 | G.HN.52 |
Polar | TM3 | R | 136 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Van-der-waals | TM3 | R | 136 | 3x50 | G.H5 | N | 353 | G.H5.24 |
Hydrophobic | TM6 | R | 237 | 6x29 | G.H5 | R | 350 | G.H5.21 |
Van-der-waals | TM6 | R | 237 | 6x29 | G.H5 | R | 350 | G.H5.21 |
Hydrophobic | ICL2 | P | 145 | 34x52 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM5 | Y | 215 | 5x58 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM2 | M | 74 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Van-der-waals | TM2 | M | 74 | 2x39 | G.H5 | F | 352 | G.H5.23 |
Hydrophobic | ICL2 | Y | 146 | 34x53 | G.H5 | E | 351 | G.H5.22 |
Van-der-waals | ICL2 | Y | 146 | 34x53 | G.H5 | E | 351 | G.H5.22 |
Hydrophobic | ICL2 | M | 143 | 34x50 | G.H5 | K | 341 | G.H5.12 |
Van-der-waals | ICL2 | M | 143 | 34x50 | G.H5 | K | 341 | G.H5.12 |
Polar | TM5 | S | 226 | 5x69 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM5 | S | 226 | 5x69 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | S | 226 | 5x69 | G.H5 | D | 342 | G.H5.13 |
Polar | ICL2 | Y | 146 | 34x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | T | 139 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | T | 139 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Polar | H8 | S | 302 | 8x47 | G.H5 | V | 355 | G.H5.26 |
Polar | TM6 | N | 231 | 6x23 | G.S6 | S | 322 | G.S6.03 |
Van-der-waals | TM6 | N | 231 | 6x23 | G.S6 | S | 322 | G.S6.03 |
Hydrophobic | TM3 | M | 140 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Van-der-waals | TM3 | M | 140 | 3x54 | G.H5 | L | 345 | G.H5.16 |
Polar | ICL2 | R | 144 | 34x51 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | ICL2 | R | 144 | 34x51 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM4 | K | 150 | 4x38 | G.hns1 | R | 33 | G.hns1.02 |
Hydrophobic | ICL2 | M | 143 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | M | 143 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | TM5 | I | 218 | 5x61 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM3 | M | 140 | 3x54 | G.H5 | L | 354 | G.H5.25 |