G13 -
S1P4 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 19.9
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | C-term | L | 375 | - | G.s4h3 | Q | 254 | G.s4h3.06 |
Hydrophobic | C-term | S | 383 | - | H.hdhe | L | 170 | H.hdhe.03 |
Hydrophobic | TM6 | L | 249 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | L | 249 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Polar | C-term | R | 372 | - | G.HG | D | 307 | G.HG.17 |
Van-der-waals | C-term | R | 372 | - | G.HG | D | 307 | G.HG.17 |
Hydrophobic | C-term | V | 381 | - | H.HB | M | 123 | H.HB.10 |
Hydrophobic | TM6 | K | 245 | 6x29 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | F | 361 | - | G.H3 | I | 275 | G.H3.12 |
Van-der-waals | C-term | F | 361 | - | G.H3 | I | 275 | G.H3.12 |
Hydrophobic | C-term | S | 377 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Van-der-waals | C-term | S | 377 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Hydrophobic | TM6 | K | 245 | 6x29 | G.H5 | K | 372 | G.H5.21 |
Van-der-waals | TM6 | K | 245 | 6x29 | G.H5 | K | 372 | G.H5.21 |
Polar | C-term | S | 380 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | S | 380 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | S | 380 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | TM6 | R | 248 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | R | 248 | 6x32 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | R | 370 | - | G.hgh4 | L | 310 | G.hgh4.03 |
Van-der-waals | C-term | R | 370 | - | G.hgh4 | L | 310 | G.hgh4.03 |
Polar | ICL2 | A | 152 | 34x52 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | ICL2 | A | 152 | 34x52 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | A | 152 | 34x52 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM2 | W | 80 | 2x38 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | W | 80 | 2x38 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | ICL2 | G | 155 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Polar | C-term | S | 377 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | C-term | S | 377 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | S | 377 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | L | 367 | - | G.h4s6 | K | 333 | G.h4s6.01 |
Hydrophobic | TM5 | S | 233 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Van-der-waals | TM5 | S | 233 | 5x68 | G.H5 | D | 364 | G.H5.13 |
Hydrophobic | C-term | S | 377 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | S | 377 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | C-term | F | 361 | - | G.H3 | T | 274 | G.H3.11 |
Hydrophobic | C-term | R | 358 | - | G.H2 | F | 234 | G.H2.08 |
Hydrophobic | C-term | R | 382 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | S | 383 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | S | 383 | - | H.HA | V | 98 | H.HA.21 |
Polar | H8 | E | 313 | 8x49 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | M | 147 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | M | 147 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Polar | C-term | S | 383 | - | H.hdhe | G | 171 | H.hdhe.04 |
Hydrophobic | ICL2 | P | 150 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | P | 150 | 34x50 | G.H5 | I | 366 | G.H5.15 |
Ionic | ICL2 | E | 153 | 34x53 | G.hns1 | R | 47 | G.hns1.03 |
Polar | TM6 | K | 245 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | K | 245 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | K | 245 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Polar | C-term | E | 373 | - | G.HG | D | 307 | G.HG.17 |
Polar | C-term | S | 379 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | S | 379 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | S | 379 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | F | 369 | - | G.H3 | L | 269 | G.H3.06 |
Van-der-waals | C-term | F | 369 | - | G.H3 | L | 269 | G.H3.06 |
Polar | C-term | S | 377 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | S | 377 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Aromatic | C-term | F | 369 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Hydrophobic | C-term | F | 369 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Van-der-waals | C-term | F | 369 | - | G.hgh4 | F | 309 | G.hgh4.02 |
Hydrophobic | C-term | S | 379 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | I | 378 | - | H.HA | L | 106 | H.HA.29 |
Van-der-waals | C-term | I | 378 | - | H.HA | L | 106 | H.HA.29 |
Hydrophobic | TM2 | Y | 82 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | Y | 82 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | I | 384 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | C-term | I | 384 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | TM2 | V | 81 | 2x39 | G.H5 | Q | 373 | G.H5.22 |
Polar | TM3 | R | 143 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 143 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 143 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | S | 383 | - | H.HA | K | 94 | H.HA.17 |
Van-der-waals | C-term | S | 383 | - | H.HA | K | 94 | H.HA.17 |
Hydrophobic | ICL2 | E | 153 | 34x53 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | E | 153 | 34x53 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM2 | L | 85 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | L | 85 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL2 | A | 152 | 34x52 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | A | 152 | 34x52 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | M | 371 | - | G.H3 | T | 266 | G.H3.03 |
Van-der-waals | C-term | M | 371 | - | G.H3 | T | 266 | G.H3.03 |
Hydrophobic | ICL2 | V | 151 | 34x51 | G.hns1 | R | 47 | G.hns1.03 |
Van-der-waals | ICL2 | V | 151 | 34x51 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | C-term | R | 382 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Van-der-waals | C-term | R | 382 | - | G.s4h3 | M | 257 | G.s4h3.09 |
Hydrophobic | C-term | I | 384 | - | G.hfs2 | R | 200 | G.hfs2.02 |
Van-der-waals | C-term | I | 384 | - | G.hfs2 | R | 200 | G.hfs2.02 |
Hydrophobic | C-term | I | 384 | - | G.hfs2 | P | 202 | G.hfs2.04 |
Van-der-waals | C-term | I | 384 | - | G.hfs2 | P | 202 | G.hfs2.04 |
Polar | C-term | S | 380 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | S | 380 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Van-der-waals | C-term | S | 380 | - | G.s4h3 | R | 260 | G.s4h3.12 |
Hydrophobic | C-term | S | 376 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Hydrophobic | ICL2 | V | 151 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | V | 151 | 34x51 | G.S3 | V | 216 | G.S3.01 |
Polar | C-term | I | 378 | - | H.HA | K | 105 | H.HA.28 |
Hydrophobic | C-term | I | 378 | - | H.HA | K | 105 | H.HA.28 |
Van-der-waals | C-term | I | 378 | - | H.HA | K | 105 | H.HA.28 |
Polar | C-term | I | 378 | - | H.HD | E | 167 | H.HD.12 |
Hydrophobic | C-term | I | 378 | - | H.HD | E | 167 | H.HD.12 |
Van-der-waals | C-term | I | 378 | - | H.HD | E | 167 | H.HD.12 |
Polar | C-term | S | 380 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | S | 380 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | F | 361 | - | G.H2 | W | 233 | G.H2.07 |
Hydrophobic | TM5 | V | 230 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM5 | V | 230 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | C-term | V | 381 | - | H.HA | V | 98 | H.HA.21 |
Van-der-waals | C-term | V | 381 | - | H.HA | V | 98 | H.HA.21 |
Hydrophobic | C-term | I | 384 | - | H.hdhe | G | 171 | H.hdhe.04 |
Polar | ICL2 | S | 154 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | S | 154 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | S | 154 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Polar | ICL2 | T | 157 | 34x57 | G.HN | T | 43 | G.HN.52 |
Hydrophobic | C-term | I | 384 | - | G.s1h1 | E | 58 | G.s1h1.04 |
Polar | C-term | T | 351 | - | G.H3 | R | 279 | G.H3.16 |
Van-der-waals | C-term | T | 351 | - | G.H3 | R | 279 | G.H3.16 |
Hydrophobic | C-term | L | 375 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Van-der-waals | C-term | L | 375 | - | G.hgh4 | Y | 308 | G.hgh4.01 |
Hydrophobic | ICL2 | A | 156 | 34x56 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | A | 156 | 34x56 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | C-term | F | 369 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Van-der-waals | C-term | F | 369 | - | G.hgh4 | E | 311 | G.hgh4.04 |
Hydrophobic | TM3 | M | 147 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | M | 147 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL2 | T | 157 | 34x57 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | T | 157 | 34x57 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | T | 157 | 34x57 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM2 | V | 81 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | V | 81 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | C-term | S | 379 | - | H.hdhe | F | 168 | H.hdhe.01 |
Van-der-waals | C-term | S | 379 | - | H.hdhe | F | 168 | H.hdhe.01 |
Polar | H8 | R | 312 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | R | 312 | 8x48 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM6 | L | 249 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | L | 249 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | H8 | V | 314 | 8x50 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM5 | L | 229 | 5x64 | G.H5 | L | 367 | G.H5.16 |
Polar | H8 | S | 311 | 8x47 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | C-term | R | 372 | - | G.hgh4 | L | 310 | G.hgh4.03 |
Polar | C-term | V | 381 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | V | 381 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | V | 381 | - | H.HA | D | 101 | H.HA.24 |
Aromatic | TM6 | R | 239 | 6x23 | G.S6 | Y | 343 | G.S6.02 |
Hydrophobic | TM5 | V | 230 | 5x65 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | TM2 | W | 80 | 2x38 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | C-term | L | 375 | - | G.s4h3 | N | 263 | G.s4h3.15 |
Van-der-waals | C-term | L | 375 | - | G.s4h3 | N | 263 | G.s4h3.15 |
Polar | C-term | S | 379 | - | H.HA | D | 101 | H.HA.24 |
Van-der-waals | C-term | S | 379 | - | H.HA | D | 101 | H.HA.24 |
Hydrophobic | C-term | S | 360 | - | G.H3 | T | 274 | G.H3.11 |
Polar | H8 | S | 311 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | S | 311 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | S | 311 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | ICL3 | K | 236 | - | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | C-term | V | 381 | - | H.HA | R | 97 | H.HA.20 |
Polar | C-term | S | 383 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | C-term | S | 383 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Van-der-waals | C-term | S | 383 | - | H.hdhe | Q | 169 | H.hdhe.02 |
Hydrophobic | TM3 | M | 147 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | M | 147 | 3x54 | G.H5 | L | 374 | G.H5.23 |
Polar | C-term | S | 360 | - | G.H3 | N | 278 | G.H3.15 |
Van-der-waals | C-term | S | 360 | - | G.H3 | N | 278 | G.H3.15 |
Polar | TM3 | T | 146 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | T | 146 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | T | 146 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | P | 150 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM3 | M | 147 | 3x54 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | C-term | F | 361 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Van-der-waals | C-term | F | 361 | - | G.h2s4 | F | 237 | G.h2s4.01 |
Hydrophobic | C-term | S | 377 | - | H.hdhe | F | 168 | H.hdhe.01 |
Hydrophobic | C-term | L | 375 | - | G.s4h3 | D | 253 | G.s4h3.05 |
Van-der-waals | C-term | L | 375 | - | G.s4h3 | D | 253 | G.s4h3.05 |
Hydrophobic | C-term | M | 371 | - | G.s4h3 | N | 263 | G.s4h3.15 |
Van-der-waals | C-term | M | 371 | - | G.s4h3 | N | 263 | G.s4h3.15 |
Polar | TM6 | R | 239 | 6x23 | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | TM6 | R | 239 | 6x23 | G.S6 | L | 342 | G.S6.01 |
Van-der-waals | TM6 | R | 239 | 6x23 | G.S6 | L | 342 | G.S6.01 |
Hydrophobic | C-term | L | 375 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Van-der-waals | C-term | L | 375 | - | G.s4h3 | V | 255 | G.s4h3.07 |
Hydrophobic | C-term | F | 369 | - | G.H3 | T | 266 | G.H3.03 |
Hydrophobic | TM6 | R | 239 | 6x23 | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | TM6 | R | 239 | 6x23 | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | TM7 | R | 310 | 7x56 | G.H5 | M | 375 | G.H5.24 |