G11 -
S1P5 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 81.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 12.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM5 | L | 226 | 5x72 | G.H5 | A | 343 | G.H5.10 |
Hydrophobic | TM5 | V | 219 | 5x65 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | V | 392 | - | G.H2 | H | 218 | G.H2.09 |
Polar | C-term | L | 356 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | L | 356 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | TM3 | M | 137 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Van-der-waals | TM3 | M | 137 | 3x54 | G.H5 | L | 353 | G.H5.20 |
Polar | TM6 | R | 242 | 6x26 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | TM6 | R | 242 | 6x26 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | TM6 | R | 242 | 6x26 | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | TM6 | R | 245 | 6x29 | G.h4s6 | I | 323 | G.h4s6.20 |
Van-der-waals | TM6 | R | 245 | 6x29 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | TM5 | P | 230 | 5x76 | G.H4 | L | 310 | G.H4.12 |
Van-der-waals | TM5 | P | 230 | 5x76 | G.H4 | L | 310 | G.H4.12 |
Hydrophobic | TM3 | M | 137 | 3x54 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | L | 356 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 356 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM5 | I | 215 | 5x61 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | T | 390 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | ICL2 | R | 140 | 34x50 | G.S3 | I | 199 | G.S3.01 |
Van-der-waals | ICL2 | R | 140 | 34x50 | G.S3 | I | 199 | G.S3.01 |
Hydrophobic | C-term | L | 352 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | L | 352 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | TM6 | L | 249 | 6x33 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM3 | M | 137 | 3x54 | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | TM3 | M | 137 | 3x54 | G.H5 | N | 352 | G.H5.19 |
Polar | TM3 | T | 136 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM3 | T | 136 | 3x53 | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | C-term | S | 381 | - | H.HA | L | 78 | H.HA.10 |
Polar | C-term | R | 389 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | R | 389 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | TM6 | L | 253 | 6x37 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | L | 249 | 6x33 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | TM5 | L | 226 | 5x72 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM5 | L | 226 | 5x72 | G.H5 | D | 346 | G.H5.13 |
Polar | TM3 | R | 133 | 3x50 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | TM3 | M | 137 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM3 | M | 137 | 3x54 | G.H5 | L | 349 | G.H5.16 |
Polar | C-term | G | 377 | - | H.hbhc | E | 119 | H.hbhc.01 |
Hydrophobic | C-term | G | 377 | - | H.hbhc | E | 119 | H.hbhc.01 |
Van-der-waals | C-term | G | 377 | - | H.hbhc | E | 119 | H.hbhc.01 |
Polar | C-term | L | 391 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | C-term | L | 391 | - | G.S2 | I | 189 | G.S2.01 |
Van-der-waals | C-term | L | 391 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | C-term | L | 391 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | L | 391 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | TM6 | R | 245 | 6x29 | G.H5 | K | 354 | G.H5.21 |
Van-der-waals | C-term | T | 390 | - | G.S2 | I | 189 | G.S2.01 |
Hydrophobic | TM2 | M | 71 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM2 | M | 71 | 2x39 | G.H5 | Y | 356 | G.H5.23 |
Polar | C-term | P | 353 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | P | 353 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | P | 353 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | TM2 | M | 71 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | M | 71 | 2x39 | G.H5 | E | 355 | G.H5.22 |
Polar | TM3 | T | 136 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | T | 136 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | T | 136 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | ICL2 | R | 140 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | R | 140 | 34x50 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | ICL2 | P | 142 | 34x52 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | P | 142 | 34x52 | G.hns1 | R | 37 | G.hns1.02 |
Polar | TM6 | L | 249 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | L | 249 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | L | 249 | 6x33 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM3 | M | 137 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL2 | G | 141 | 34x51 | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM6 | R | 245 | 6x29 | G.H5 | V | 359 | G.H5.26 |
Polar | TM3 | R | 133 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | R | 133 | 3x50 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | L | 356 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | ICL2 | V | 145 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | V | 145 | 34x55 | G.hns1 | R | 37 | G.hns1.02 |
Polar | C-term | S | 378 | - | H.hbhc | E | 119 | H.hbhc.01 |
Van-der-waals | C-term | S | 378 | - | H.hbhc | E | 119 | H.hbhc.01 |
Hydrophobic | TM2 | M | 71 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | TM2 | M | 71 | 2x39 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | C-term | L | 352 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | ICL2 | V | 145 | 34x55 | G.HN | R | 34 | G.HN.52 |
Polar | C-term | T | 386 | - | G.H1 | R | 60 | G.H1.09 |
Polar | C-term | T | 379 | - | H.hbhc | E | 119 | H.hbhc.01 |
Hydrophobic | C-term | T | 379 | - | H.hbhc | E | 119 | H.hbhc.01 |
Van-der-waals | C-term | T | 379 | - | H.hbhc | E | 119 | H.hbhc.01 |
Hydrophobic | TM5 | V | 219 | 5x65 | G.H5 | L | 349 | G.H5.16 |
Ionic | C-term | D | 357 | - | G.H2 | R | 214 | G.H2.05 |
Polar | C-term | D | 357 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | D | 357 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | D | 357 | - | G.H2 | R | 214 | G.H2.05 |
Ionic | ICL2 | R | 140 | 34x50 | G.s2s3 | E | 197 | G.s2s3.01 |
Polar | ICL2 | R | 140 | 34x50 | G.s2s3 | E | 197 | G.s2s3.01 |
Van-der-waals | ICL2 | R | 140 | 34x50 | G.s2s3 | E | 197 | G.s2s3.01 |
Polar | TM6 | T | 252 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | T | 252 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM6 | T | 252 | 6x36 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM5 | N | 222 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | TM5 | N | 222 | 5x68 | G.H5 | L | 349 | G.H5.16 |
Polar | TM3 | E | 132 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | E | 132 | 3x49 | G.H5 | Y | 356 | G.H5.23 |
Polar | TM6 | R | 245 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | R | 245 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | R | 245 | 6x29 | G.H5 | Q | 350 | G.H5.17 |
Polar | ICL2 | A | 143 | 34x53 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | A | 143 | 34x53 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | A | 143 | 34x53 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | R | 140 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | ICL2 | R | 140 | 34x50 | G.H5 | K | 345 | G.H5.12 |
Polar | H8 | N | 310 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | H8 | N | 310 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Van-der-waals | H8 | N | 310 | 8x47 | G.H5 | N | 357 | G.H5.24 |
Hydrophobic | ICL2 | G | 141 | 34x51 | G.S3 | I | 199 | G.S3.01 |
Hydrophobic | TM5 | P | 227 | 5x73 | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | TM5 | P | 227 | 5x73 | G.H5 | F | 339 | G.H5.06 |
Polar | ICL2 | P | 144 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | P | 144 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | P | 144 | 34x54 | G.hns1 | R | 37 | G.hns1.02 |
Ionic | TM6 | R | 242 | 6x26 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM6 | R | 242 | 6x26 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM6 | R | 242 | 6x26 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | TM6 | R | 242 | 6x26 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | C-term | A | 388 | - | G.S2 | E | 191 | G.S2.03 |
Van-der-waals | C-term | A | 388 | - | G.S2 | E | 191 | G.S2.03 |
Hydrophobic | TM6 | A | 248 | 6x32 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | C-term | A | 388 | - | G.S2 | Y | 192 | G.S2.04 |
Ionic | TM6 | R | 245 | 6x29 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM6 | R | 245 | 6x29 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | TM6 | R | 245 | 6x29 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM5 | L | 226 | 5x72 | G.S6 | Y | 325 | G.S6.02 |
Van-der-waals | TM5 | L | 226 | 5x72 | G.S6 | Y | 325 | G.S6.02 |
Hydrophobic | TM5 | L | 226 | 5x72 | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | TM5 | L | 226 | 5x72 | G.H5 | F | 339 | G.H5.06 |
Hydrophobic | ICL2 | P | 142 | 34x52 | G.S1 | L | 40 | G.S1.02 |
Van-der-waals | ICL2 | P | 142 | 34x52 | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | C-term | L | 356 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | L | 356 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | C-term | A | 388 | - | G.S2 | I | 190 | G.S2.02 |
Van-der-waals | C-term | A | 388 | - | G.S2 | I | 190 | G.S2.02 |
Hydrophobic | TM5 | Y | 212 | 5x58 | G.H5 | L | 358 | G.H5.25 |