G13 -
S1P5 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 74.1
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.5
iPTM Score: 0.4
PAE mean: 21.2
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | TM3 | R | 139 | 3x56 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | P | 142 | 34x52 | G.S1 | L | 48 | G.S1.01 |
Van-der-waals | ICL2 | P | 142 | 34x52 | G.S1 | L | 48 | G.S1.01 |
Hydrophobic | TM5 | V | 219 | 5x65 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | H8 | L | 313 | 8x50 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM5 | N | 222 | 5x68 | G.H5 | L | 367 | G.H5.16 |
Polar | ICL2 | P | 142 | 34x52 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | P | 142 | 34x52 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | P | 142 | 34x52 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM5 | R | 225 | 5x71 | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | TM2 | L | 75 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | L | 75 | 2x43 | G.H5 | L | 376 | G.H5.25 |
Polar | ICL2 | G | 141 | 34x51 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | R | 140 | 34x50 | G.H5 | K | 363 | G.H5.12 |
Polar | ICL2 | S | 146 | 34x56 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | ICL2 | S | 146 | 34x56 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | S | 146 | 34x56 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM2 | M | 71 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | M | 71 | 2x39 | G.H5 | L | 376 | G.H5.25 |
Polar | TM6 | R | 245 | 6x29 | G.h4s6 | K | 340 | G.h4s6.19 |
Hydrophobic | TM6 | R | 245 | 6x29 | G.h4s6 | K | 340 | G.h4s6.19 |
Van-der-waals | TM6 | R | 245 | 6x29 | G.h4s6 | K | 340 | G.h4s6.19 |
Hydrophobic | TM6 | L | 249 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | L | 249 | 6x33 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM6 | L | 249 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM6 | L | 249 | 6x33 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | G | 141 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Van-der-waals | ICL2 | G | 141 | 34x51 | G.H5 | I | 366 | G.H5.15 |
Polar | TM3 | T | 136 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | T | 136 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Van-der-waals | TM3 | T | 136 | 3x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | TM3 | E | 132 | 3x49 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM6 | S | 246 | 6x30 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | P | 142 | 34x52 | G.h2s4 | T | 241 | G.h2s4.05 |
Polar | TM6 | R | 245 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | R | 245 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Van-der-waals | TM6 | R | 245 | 6x29 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM6 | S | 246 | 6x30 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM6 | S | 246 | 6x30 | G.H5 | L | 367 | G.H5.16 |
Polar | H8 | R | 311 | 8x48 | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | TM5 | P | 227 | 5x73 | G.H5 | R | 360 | G.H5.09 |
Hydrophobic | TM2 | F | 72 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM2 | F | 72 | 2x40 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | TM3 | M | 137 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Van-der-waals | TM3 | M | 137 | 3x54 | G.H5 | L | 371 | G.H5.20 |
Hydrophobic | ICL2 | V | 145 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | V | 145 | 34x55 | G.hns1 | K | 46 | G.hns1.02 |
Hydrophobic | TM2 | M | 71 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM2 | M | 71 | 2x39 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | P | 144 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Van-der-waals | ICL2 | P | 144 | 34x54 | G.hns1 | K | 46 | G.hns1.02 |
Polar | TM5 | N | 222 | 5x68 | G.H5 | K | 363 | G.H5.12 |
Hydrophobic | TM5 | N | 222 | 5x68 | G.H5 | K | 363 | G.H5.12 |
Van-der-waals | TM5 | N | 222 | 5x68 | G.H5 | K | 363 | G.H5.12 |
Polar | H8 | N | 310 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | H8 | N | 310 | 8x47 | G.H5 | Q | 377 | G.H5.26 |
Polar | ICL2 | R | 140 | 34x50 | G.s2s3 | K | 214 | G.s2s3.01 |
Hydrophobic | ICL2 | A | 143 | 34x53 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | ICL2 | A | 143 | 34x53 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM6 | T | 252 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM6 | T | 252 | 6x36 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | TM2 | M | 71 | 2x39 | G.H5 | Q | 373 | G.H5.22 |
Van-der-waals | TM2 | M | 71 | 2x39 | G.H5 | Q | 373 | G.H5.22 |
Hydrophobic | TM3 | T | 136 | 3x53 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM5 | L | 226 | 5x72 | G.H5 | R | 360 | G.H5.09 |
Van-der-waals | TM5 | L | 226 | 5x72 | G.H5 | R | 360 | G.H5.09 |
Polar | TM6 | R | 245 | 6x29 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | TM6 | R | 245 | 6x29 | G.h4s6 | Q | 339 | G.h4s6.13 |
Van-der-waals | TM6 | R | 245 | 6x29 | G.h4s6 | Q | 339 | G.h4s6.13 |
Hydrophobic | ICL2 | P | 142 | 34x52 | G.H5 | I | 366 | G.H5.15 |
Hydrophobic | TM6 | L | 249 | 6x33 | G.H5 | H | 368 | G.H5.17 |
Hydrophobic | TM3 | M | 137 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Van-der-waals | TM3 | M | 137 | 3x54 | G.H5 | L | 367 | G.H5.16 |
Polar | TM6 | R | 245 | 6x29 | G.h4s6 | Q | 338 | G.h4s6.12 |
Van-der-waals | TM6 | R | 245 | 6x29 | G.h4s6 | Q | 338 | G.h4s6.12 |
Ionic | TM6 | R | 239 | 6x23 | G.H4 | E | 328 | G.H4.13 |
Polar | TM6 | R | 239 | 6x23 | G.H4 | E | 328 | G.H4.13 |
Polar | ICL2 | A | 143 | 34x53 | G.H5 | N | 370 | G.H5.19 |
Hydrophobic | ICL2 | P | 142 | 34x52 | G.S1 | V | 49 | G.S1.02 |
Polar | H8 | N | 310 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Hydrophobic | H8 | N | 310 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | H8 | N | 310 | 8x47 | G.H5 | L | 376 | G.H5.25 |
Polar | TM5 | T | 232 | 5x78 | G.H4 | R | 320 | G.H4.05 |
Van-der-waals | TM5 | T | 232 | 5x78 | G.H4 | R | 320 | G.H4.05 |
Hydrophobic | TM6 | R | 245 | 6x29 | G.h4s6 | P | 341 | G.h4s6.20 |
Van-der-waals | TM6 | R | 245 | 6x29 | G.h4s6 | P | 341 | G.h4s6.20 |
Hydrophobic | TM7 | Y | 306 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Van-der-waals | TM7 | Y | 306 | 7x53 | G.H5 | L | 376 | G.H5.25 |
Polar | TM3 | R | 133 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Van-der-waals | TM3 | R | 133 | 3x50 | G.H5 | L | 374 | G.H5.23 |
Hydrophobic | ICL2 | G | 141 | 34x51 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM5 | V | 219 | 5x65 | G.H5 | L | 367 | G.H5.16 |
Hydrophobic | ICL2 | R | 140 | 34x50 | G.H5 | F | 359 | G.H5.08 |
Hydrophobic | ICL2 | R | 140 | 34x50 | G.S3 | V | 216 | G.S3.01 |
Van-der-waals | ICL2 | R | 140 | 34x50 | G.S3 | V | 216 | G.S3.01 |
Polar | TM7 | T | 309 | 7x56 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | TM7 | T | 309 | 7x56 | G.H5 | Q | 377 | G.H5.26 |
Van-der-waals | TM7 | T | 309 | 7x56 | G.H5 | Q | 377 | G.H5.26 |
Hydrophobic | ICL2 | P | 142 | 34x52 | G.hns1 | R | 47 | G.hns1.03 |
Hydrophobic | TM3 | R | 133 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Van-der-waals | TM3 | R | 133 | 3x50 | G.H5 | M | 375 | G.H5.24 |
Hydrophobic | ICL2 | R | 140 | 34x50 | G.H5 | I | 366 | G.H5.15 |