GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 69.9
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.5
PAE mean: 20.0
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | L | 267 | 2x44 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | L | 267 | 2x44 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM3 | F | 343 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | F | 343 | 3x54 | G.H5 | I | 378 | G.H5.23 |
Polar | TM3 | A | 345 | 3x56 | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL3 | L | 436 | - | G.H5 | K | 367 | G.H5.12 |
Polar | C-term | D | 784 | - | G.H2 | Q | 234 | G.H2.03 |
Van-der-waals | C-term | D | 784 | - | G.H2 | Q | 234 | G.H2.03 |
Polar | ICL2 | L | 346 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | L | 346 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | P | 645 | - | G.h1ha | G | 82 | G.h1ha.01 |
Van-der-waals | C-term | P | 645 | - | G.h1ha | G | 82 | G.h1ha.01 |
Polar | C-term | M | 776 | - | H.HA | D | 110 | H.HA.24 |
Hydrophobic | C-term | M | 776 | - | H.HA | D | 110 | H.HA.24 |
Van-der-waals | C-term | M | 776 | - | H.HA | D | 110 | H.HA.24 |
Polar | ICL2 | T | 349 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | C-term | L | 775 | - | H.HA | A | 111 | H.HA.25 |
Van-der-waals | C-term | L | 775 | - | H.HA | A | 111 | H.HA.25 |
Polar | ICL2 | Y | 350 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | Y | 350 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | Y | 350 | - | G.hns1 | R | 55 | G.hns1.02 |
Polar | C-term | A | 643 | - | G.h1ha | R | 83 | G.h1ha.02 |
Hydrophobic | C-term | A | 643 | - | G.h1ha | R | 83 | G.h1ha.02 |
Van-der-waals | C-term | A | 643 | - | G.h1ha | R | 83 | G.h1ha.02 |
Polar | C-term | T | 773 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | T | 773 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | T | 773 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | ICL3 | L | 437 | - | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | ICL2 | T | 349 | - | G.H5 | I | 370 | G.H5.15 |
Hydrophobic | TM6 | I | 445 | 6x26 | G.H5 | L | 371 | G.H5.16 |
Polar | TM6 | S | 438 | 6x19 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | TM6 | S | 438 | 6x19 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM6 | S | 438 | 6x19 | G.H5 | D | 368 | G.H5.13 |
Hydrophobic | C-term | V | 600 | - | G.H3 | E | 278 | G.H3.10 |
Polar | TM6 | K | 444 | 6x25 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | K | 444 | 6x25 | G.H5 | Q | 381 | G.H5.26 |
Aromatic | C-term | R | 562 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Hydrophobic | C-term | R | 562 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Van-der-waals | C-term | R | 562 | - | G.h3s5 | F | 287 | G.h3s5.01 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | L | 375 | G.H5.20 |
Polar | TM2 | R | 261 | 2x38 | G.H5 | K | 376 | G.H5.21 |
Van-der-waals | TM2 | R | 261 | 2x38 | G.H5 | K | 376 | G.H5.21 |
Ionic | TM2 | R | 261 | 2x38 | G.H5 | D | 377 | G.H5.22 |
Polar | TM2 | R | 261 | 2x38 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | TM2 | R | 261 | 2x38 | G.H5 | D | 377 | G.H5.22 |
Van-der-waals | TM2 | R | 261 | 2x38 | G.H5 | D | 377 | G.H5.22 |
Hydrophobic | C-term | L | 775 | - | H.HA | D | 110 | H.HA.24 |
Polar | C-term | N | 774 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | N | 774 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | N | 774 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | C-term | L | 780 | - | H.HA | V | 107 | H.HA.21 |
Van-der-waals | C-term | L | 780 | - | H.HA | V | 107 | H.HA.21 |
Hydrophobic | H8 | A | 540 | 8x49 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | C-term | L | 775 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | L | 775 | - | H.HA | K | 114 | H.HA.28 |
Polar | ICL3 | G | 435 | - | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | ICL3 | G | 435 | - | G.H5 | H | 364 | G.H5.09 |
Van-der-waals | ICL3 | G | 435 | - | G.H5 | H | 364 | G.H5.09 |
Polar | ICL2 | Q | 351 | - | G.hns1 | R | 55 | G.hns1.02 |
Polar | ICL2 | T | 349 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | T | 349 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | T | 349 | - | G.hns1 | R | 55 | G.hns1.02 |
Ionic | C-term | D | 784 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Polar | C-term | D | 784 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Hydrophobic | C-term | D | 784 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Van-der-waals | C-term | D | 784 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Hydrophobic | C-term | R | 562 | - | G.H3 | K | 284 | G.H3.16 |
Ionic | C-term | D | 782 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Polar | C-term | D | 782 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Hydrophobic | C-term | D | 782 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Van-der-waals | C-term | D | 782 | - | G.hfs2 | K | 209 | G.hfs2.06 |
Hydrophobic | TM1 | F | 252 | 1x54 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM1 | F | 252 | 1x54 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | ICL3 | L | 436 | - | G.H5 | H | 364 | G.H5.09 |
Van-der-waals | ICL3 | L | 436 | - | G.H5 | H | 364 | G.H5.09 |
Polar | C-term | L | 654 | - | G.H5 | R | 360 | G.H5.05 |
Hydrophobic | C-term | L | 654 | - | G.H5 | R | 360 | G.H5.05 |
Van-der-waals | C-term | L | 654 | - | G.H5 | R | 360 | G.H5.05 |
Polar | TM6 | E | 447 | 6x28 | G.H5 | Q | 381 | G.H5.26 |
Hydrophobic | TM6 | E | 447 | 6x28 | G.H5 | Q | 381 | G.H5.26 |
Van-der-waals | TM6 | E | 447 | 6x28 | G.H5 | Q | 381 | G.H5.26 |
Polar | C-term | T | 644 | - | G.h1ha | R | 83 | G.h1ha.02 |
Hydrophobic | C-term | T | 644 | - | G.h1ha | R | 83 | G.h1ha.02 |
Van-der-waals | C-term | T | 644 | - | G.h1ha | R | 83 | G.h1ha.02 |
Hydrophobic | ICL2 | G | 347 | - | G.H5 | L | 371 | G.H5.16 |
Polar | C-term | W | 655 | - | G.H5 | E | 357 | G.H5.02 |
Hydrophobic | C-term | W | 655 | - | G.H5 | E | 357 | G.H5.02 |
Van-der-waals | C-term | W | 655 | - | G.H5 | E | 357 | G.H5.02 |
Hydrophobic | C-term | M | 776 | - | H.HA | K | 114 | H.HA.28 |
Van-der-waals | C-term | M | 776 | - | H.HA | K | 114 | H.HA.28 |
Hydrophobic | TM2 | A | 264 | 2x41 | G.H5 | L | 380 | G.H5.25 |
Van-der-waals | TM2 | A | 264 | 2x41 | G.H5 | L | 380 | G.H5.25 |
Polar | TM3 | W | 339 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | TM3 | W | 339 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | W | 339 | 3x50 | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | C-term | V | 657 | - | G.H5 | F | 361 | G.H5.06 |
Van-der-waals | C-term | V | 657 | - | G.H5 | F | 361 | G.H5.06 |
Hydrophobic | TM3 | S | 342 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | TM3 | S | 342 | 3x53 | G.H5 | I | 378 | G.H5.23 |
Polar | C-term | D | 784 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Hydrophobic | C-term | D | 784 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Van-der-waals | C-term | D | 784 | - | G.s3h2 | Q | 231 | G.s3h2.03 |
Hydrophobic | TM6 | T | 448 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | T | 448 | 6x29 | G.H5 | M | 379 | G.H5.24 |
Hydrophobic | ICL2 | T | 348 | - | G.H5 | I | 370 | G.H5.15 |
Van-der-waals | ICL2 | T | 348 | - | G.H5 | I | 370 | G.H5.15 |
Polar | ICL2 | T | 349 | - | G.S1 | L | 57 | G.S1.01 |
Polar | ICL2 | T | 348 | - | G.H5 | N | 374 | G.H5.19 |
Van-der-waals | ICL2 | T | 348 | - | G.H5 | N | 374 | G.H5.19 |
Hydrophobic | C-term | L | 780 | - | H.HA | K | 103 | H.HA.17 |
Van-der-waals | C-term | L | 780 | - | H.HA | K | 103 | H.HA.17 |
Polar | TM5 | H | 433 | 5x76 | G.H5 | K | 367 | G.H5.12 |
Aromatic | TM5 | H | 433 | 5x76 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | TM5 | H | 433 | 5x76 | G.H5 | K | 367 | G.H5.12 |
Van-der-waals | TM5 | H | 433 | 5x76 | G.H5 | K | 367 | G.H5.12 |
Hydrophobic | C-term | M | 776 | - | H.HB | M | 132 | H.HB.10 |
Van-der-waals | C-term | M | 776 | - | H.HB | M | 132 | H.HB.10 |
Aromatic | ICL2 | Y | 350 | - | G.hns1 | R | 56 | G.hns1.03 |
Hydrophobic | ICL2 | Y | 350 | - | G.hns1 | R | 56 | G.hns1.03 |
Ionic | C-term | E | 660 | - | G.S6 | H | 348 | G.S6.03 |
Polar | H8 | T | 538 | 8x47 | G.H5 | L | 380 | G.H5.25 |
Hydrophobic | TM6 | I | 445 | 6x26 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | TM6 | A | 441 | 6x22 | G.H5 | D | 368 | G.H5.13 |
Van-der-waals | TM6 | A | 441 | 6x22 | G.H5 | D | 368 | G.H5.13 |
Polar | ICL2 | S | 354 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | ICL2 | S | 354 | - | G.hns1 | R | 55 | G.hns1.02 |
Van-der-waals | ICL2 | S | 354 | - | G.hns1 | R | 55 | G.hns1.02 |
Hydrophobic | TM6 | K | 444 | 6x25 | G.H5 | M | 379 | G.H5.24 |
Van-der-waals | TM6 | K | 444 | 6x25 | G.H5 | M | 379 | G.H5.24 |
Polar | C-term | W | 655 | - | G.H5 | R | 360 | G.H5.05 |
Hydrophobic | C-term | W | 655 | - | G.H5 | R | 360 | G.H5.05 |
Van-der-waals | C-term | W | 655 | - | G.H5 | R | 360 | G.H5.05 |
Hydrophobic | ICL3 | L | 437 | - | G.H5 | L | 371 | G.H5.16 |
Ionic | C-term | D | 777 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Polar | C-term | D | 777 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Hydrophobic | C-term | D | 777 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Van-der-waals | C-term | D | 777 | - | G.s4h3 | R | 265 | G.s4h3.12 |
Ionic | C-term | E | 650 | - | G.s2s3 | K | 220 | G.s2s3.02 |
Polar | C-term | E | 650 | - | G.s2s3 | K | 220 | G.s2s3.02 |
Hydrophobic | C-term | E | 650 | - | G.s2s3 | K | 220 | G.s2s3.02 |
Van-der-waals | C-term | E | 650 | - | G.s2s3 | K | 220 | G.s2s3.02 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | T | 778 | - | H.HB | M | 132 | H.HB.10 |
Hydrophobic | TM6 | A | 441 | 6x22 | G.H5 | L | 371 | G.H5.16 |
Van-der-waals | TM6 | A | 441 | 6x22 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | C-term | V | 657 | - | G.H5 | H | 364 | G.H5.09 |
Van-der-waals | C-term | V | 657 | - | G.H5 | H | 364 | G.H5.09 |
Hydrophobic | ICL2 | G | 347 | - | G.H5 | I | 370 | G.H5.15 |
Polar | C-term | N | 653 | - | G.H5 | R | 360 | G.H5.05 |
Hydrophobic | C-term | N | 653 | - | G.H5 | R | 360 | G.H5.05 |
Van-der-waals | C-term | N | 653 | - | G.H5 | R | 360 | G.H5.05 |
Hydrophobic | ICL2 | T | 349 | - | G.h2s4 | T | 246 | G.h2s4.05 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | I | 378 | G.H5.23 |
Van-der-waals | ICL2 | L | 346 | - | G.H5 | I | 378 | G.H5.23 |
Hydrophobic | ICL3 | L | 436 | - | G.H5 | F | 363 | G.H5.08 |
Hydrophobic | C-term | V | 639 | - | G.HN | R | 6 | G.HN.06 |
Hydrophobic | TM5 | I | 429 | 5x72 | G.H5 | L | 371 | G.H5.16 |
Hydrophobic | TM6 | K | 444 | 6x25 | G.H5 | L | 375 | G.H5.20 |
Hydrophobic | C-term | P | 645 | - | G.h1ha | R | 83 | G.h1ha.02 |
Van-der-waals | C-term | P | 645 | - | G.h1ha | R | 83 | G.h1ha.02 |
Van-der-waals | C-term | F | 787 | - | G.H2 | Q | 236 | G.H2.05 |