Gi2 - SMO complex model

GPCR CLASS (FAMILY)

F (Frizzled)

SPECIES

Homo sapiens

G PROTEIN FAMILY

Gi/o

DATE

2023-09-15

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.


Tertiary structure confidence

(pLDDT score) avg.: 72.1

Very high (>90)
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered

PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 16.2


GPCR - G protein interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (Gα residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction cut-off:

Residue numbering:

GPCR-G protein backbone (bb) or sidechain (sc):





Structures

Sequence Color

Gα, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Gα
segment
AA
Number		 Generic
number
Hydrophobic TM2 R 261 2x38 G.H5 K 350 G.H5.21
Van-der-waals TM2 R 261 2x38 G.H5 K 350 G.H5.21
Hydrophobic C-term L 603 - G.H2 R 209 G.H2.04
Van-der-waals C-term L 603 - G.H2 R 209 G.H2.04
Hydrophobic C-term V 600 - G.H3 L 250 G.H3.08
Van-der-waals C-term V 600 - G.H3 L 250 G.H3.08
Polar C-term G 598 - G.H3 S 253 G.H3.11
Hydrophobic C-term G 598 - G.H3 S 253 G.H3.11
Van-der-waals C-term G 598 - G.H3 S 253 G.H3.11
Hydrophobic ICL2 T 348 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 T 348 - G.hns1 A 31 G.hns1.02
Polar ICL3 G 435 - G.H5 Q 334 G.H5.05
Hydrophobic C-term A 601 - G.H2 R 206 G.H2.01
Hydrophobic ICL3 L 437 - G.H5 I 345 G.H5.16
Hydrophobic C-term L 704 - H.HA Q 68 H.HA.06
Polar ICL2 L 346 - G.H5 I 345 G.H5.16
Hydrophobic ICL2 L 346 - G.H5 I 345 G.H5.16
Polar C-term C 712 - H.HB C 112 H.HB.14
Hydrophobic C-term C 712 - H.HB C 112 H.HB.14
Polar TM3 A 345 3x56 G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 346 - G.H5 L 349 G.H5.20
Polar TM6 T 448 6x29 G.H5 L 354 G.H5.25
Hydrophobic TM6 T 448 6x29 G.H5 L 354 G.H5.25
Van-der-waals TM6 T 448 6x29 G.H5 L 354 G.H5.25
Polar ICL2 T 349 - G.hns1 A 30 G.hns1.01
Hydrophobic TM2 A 264 2x41 G.H5 G 353 G.H5.24
Hydrophobic C-term G 602 - G.H2 R 209 G.H2.04
Polar ICL2 Q 351 - G.H5 D 351 G.H5.22
Van-der-waals ICL2 Q 351 - G.H5 D 351 G.H5.22
Hydrophobic C-term F 605 - G.H2 I 213 G.H2.08
Van-der-waals C-term F 605 - G.H2 I 213 G.H2.08
Hydrophobic C-term V 600 - G.H3 I 254 G.H3.12
Hydrophobic ICL3 L 436 - G.s2s3 K 193 G.s2s3.01
Ionic TM2 R 261 2x38 G.h3s5 D 262 G.h3s5.02
Polar TM2 R 261 2x38 G.h3s5 D 262 G.h3s5.02
Van-der-waals TM2 R 261 2x38 G.h3s5 D 262 G.h3s5.02
Hydrophobic TM7 W 535 7x55 G.H5 L 354 G.H5.25
Van-der-waals TM7 W 535 7x55 G.H5 L 354 G.H5.25
Polar ICL2 T 348 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 T 348 - G.H5 N 348 G.H5.19
Polar ICL2 T 349 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 T 349 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 T 349 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 T 348 - G.H5 I 344 G.H5.15
Van-der-waals ICL2 T 348 - G.H5 I 344 G.H5.15
Polar ICL2 Y 350 - G.hns1 A 31 G.hns1.02
Hydrophobic ICL2 Y 350 - G.hns1 A 31 G.hns1.02
Van-der-waals ICL2 Y 350 - G.hns1 A 31 G.hns1.02
Hydrophobic TM3 F 343 3x54 G.H5 C 352 G.H5.23
Hydrophobic C-term V 600 - G.H2 R 209 G.H2.04
Hydrophobic C-term V 600 - G.H3 S 253 G.H3.11
Van-der-waals C-term V 600 - G.H3 S 253 G.H3.11
Hydrophobic C-term F 605 - G.H2 K 210 G.H2.05
Van-der-waals C-term F 605 - G.H2 K 210 G.H2.05
Hydrophobic C-term F 605 - G.H2 W 212 G.H2.07
Hydrophobic TM6 T 448 6x29 G.H5 L 349 G.H5.20
Hydrophobic TM6 A 441 6x22 G.H5 I 345 G.H5.16
Hydrophobic ICL2 Y 350 - G.HN G 27 G.HN.51
Hydrophobic TM3 F 343 3x54 G.H5 L 354 G.H5.25
Van-der-waals TM3 F 343 3x54 G.H5 L 354 G.H5.25
Ionic C-term R 709 - H.hbhc E 116 H.hbhc.04
Polar C-term R 709 - H.hbhc E 116 H.hbhc.04
Hydrophobic C-term R 709 - H.hbhc E 116 H.hbhc.04
Van-der-waals C-term R 709 - H.hbhc E 116 H.hbhc.04
Hydrophobic C-term A 601 - G.H3 E 246 G.H3.04
Polar C-term L 603 - G.H2 R 206 G.H2.01
Hydrophobic TM6 K 444 6x25 G.H5 L 349 G.H5.20
Polar ICL2 Y 350 - G.HN E 28 G.HN.52
Hydrophobic ICL2 Y 350 - G.HN E 28 G.HN.52
Hydrophobic ICL2 T 349 - G.h2s4 T 220 G.h2s4.05
Hydrophobic TM3 W 339 3x50 G.H5 L 354 G.H5.25
Hydrophobic ICL2 T 349 - G.H5 I 344 G.H5.15
Hydrophobic C-term H 596 - G.h4s6 K 313 G.h4s6.03
Ionic C-term H 596 - G.H3 D 252 G.H3.10
Hydrophobic C-term L 603 - G.H2 K 210 G.H2.05
Van-der-waals C-term L 603 - G.H2 K 210 G.H2.05
Hydrophobic ICL3 L 436 - G.H5 F 337 G.H5.08
Van-der-waals ICL3 L 436 - G.H5 F 337 G.H5.08
Polar C-term V 600 - G.H3 K 249 G.H3.07
Hydrophobic C-term L 603 - G.H2 W 212 G.H2.07
Van-der-waals C-term L 603 - G.H2 W 212 G.H2.07
Polar TM6 S 438 6x19 G.H5 D 342 G.H5.13
Hydrophobic TM6 S 438 6x19 G.H5 D 342 G.H5.13
Van-der-waals TM6 S 438 6x19 G.H5 D 342 G.H5.13
Hydrophobic C-term R 562 - G.H3 K 258 G.H3.16
Aromatic TM6 K 444 6x25 G.H5 F 355 G.H5.26
Hydrophobic TM6 K 444 6x25 G.H5 F 355 G.H5.26
Van-der-waals TM6 K 444 6x25 G.H5 F 355 G.H5.26
Ionic TM2 R 261 2x38 G.H5 D 351 G.H5.22
Polar TM2 R 261 2x38 G.H5 D 351 G.H5.22
Hydrophobic TM2 R 261 2x38 G.H5 D 351 G.H5.22
Van-der-waals TM2 R 261 2x38 G.H5 D 351 G.H5.22
Hydrophobic TM2 P 263 2x40 G.H5 C 352 G.H5.23
Polar TM3 W 339 3x50 G.H5 C 352 G.H5.23
Hydrophobic TM3 W 339 3x50 G.H5 C 352 G.H5.23
Van-der-waals TM3 W 339 3x50 G.H5 C 352 G.H5.23
Hydrophobic C-term V 600 - G.H2 W 212 G.H2.07
Hydrophobic C-term G 602 - G.H2 R 206 G.H2.01
Van-der-waals C-term G 602 - G.H2 R 206 G.H2.01
Polar C-term P 599 - G.H3 K 249 G.H3.07
Hydrophobic C-term P 599 - G.H3 K 249 G.H3.07
Van-der-waals C-term P 599 - G.H3 K 249 G.H3.07
Hydrophobic TM6 I 445 6x26 G.H5 I 345 G.H5.16
Hydrophobic C-term F 605 - G.h2s4 F 216 G.h2s4.01
Hydrophobic TM2 P 263 2x40 G.H5 D 351 G.H5.22
Van-der-waals TM2 P 263 2x40 G.H5 D 351 G.H5.22
Polar TM2 R 261 2x38 G.H5 N 347 G.H5.18
Van-der-waals TM2 R 261 2x38 G.H5 N 347 G.H5.18
Hydrophobic TM6 A 441 6x22 G.H5 D 342 G.H5.13
Van-der-waals TM6 A 441 6x22 G.H5 D 342 G.H5.13
Polar ICL2 L 346 - G.H5 N 348 G.H5.19
Hydrophobic ICL2 L 346 - G.H5 N 348 G.H5.19
Van-der-waals ICL2 L 346 - G.H5 N 348 G.H5.19
Van-der-waals C-term A 601 - G.H2 R 209 G.H2.04
Ionic C-term D 606 - G.H2 K 210 G.H2.05
Polar C-term D 606 - G.H2 K 210 G.H2.05
Van-der-waals C-term D 606 - G.H2 K 210 G.H2.05
Hydrophobic TM3 S 342 3x53 G.H5 C 352 G.H5.23
Van-der-waals TM3 S 342 3x53 G.H5 C 352 G.H5.23
Ionic TM6 K 440 6x21 G.h4s6 E 319 G.h4s6.12
Polar TM6 K 440 6x21 G.h4s6 E 319 G.h4s6.12
Hydrophobic TM6 K 440 6x21 G.h4s6 E 319 G.h4s6.12
Van-der-waals TM6 K 440 6x21 G.h4s6 E 319 G.h4s6.12
Hydrophobic ICL2 G 347 - G.H5 I 344 G.H5.15
Polar C-term A 604 - G.H2 K 210 G.H2.05
Hydrophobic C-term A 604 - G.H2 K 210 G.H2.05
Van-der-waals C-term A 604 - G.H2 K 210 G.H2.05
Polar ICL2 T 349 - G.S1 E 33 G.S1.01
Polar C-term P 599 - G.H3 L 250 G.H3.08
Hydrophobic C-term P 599 - G.H3 L 250 G.H3.08
Van-der-waals C-term P 599 - G.H3 L 250 G.H3.08
Hydrophobic TM6 I 445 6x26 G.H5 L 349 G.H5.20