GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 72.5
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.7
PAE mean: 15.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | ICL2 | G | 347 | - | G.H5 | K | 345 | G.H5.12 |
Ionic | TM2 | R | 261 | 2x38 | G.H5 | E | 355 | G.H5.22 |
Polar | TM2 | R | 261 | 2x38 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM2 | R | 261 | 2x38 | G.H5 | E | 355 | G.H5.22 |
Van-der-waals | TM2 | R | 261 | 2x38 | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | TM6 | S | 438 | 6x19 | G.h4s6 | I | 323 | G.h4s6.20 |
Hydrophobic | C-term | V | 657 | - | G.h4s6 | I | 323 | G.h4s6.20 |
Ionic | C-term | R | 562 | - | G.h4s6 | D | 319 | G.h4s6.10 |
Ionic | TM6 | K | 440 | 6x21 | G.h4s6 | D | 321 | G.h4s6.12 |
Polar | TM6 | K | 440 | 6x21 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | TM6 | K | 440 | 6x21 | G.h4s6 | D | 321 | G.h4s6.12 |
Van-der-waals | TM6 | K | 440 | 6x21 | G.h4s6 | D | 321 | G.h4s6.12 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | A | 441 | 6x22 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | TM6 | A | 441 | 6x22 | G.H5 | Q | 350 | G.H5.17 |
Polar | ICL2 | T | 349 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | T | 349 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | T | 349 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | C-term | V | 600 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | ICL2 | T | 349 | - | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | TM5 | I | 429 | 5x72 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL3 | L | 436 | - | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | ICL2 | T | 348 | - | G.H5 | I | 348 | G.H5.15 |
Van-der-waals | ICL2 | T | 348 | - | G.H5 | I | 348 | G.H5.15 |
Polar | ICL2 | Q | 351 | - | G.H5 | E | 355 | G.H5.22 |
Hydrophobic | ICL2 | T | 349 | - | G.S1 | L | 40 | G.S1.02 |
Hydrophobic | TM6 | I | 445 | 6x26 | G.H5 | L | 353 | G.H5.20 |
Hydrophobic | C-term | V | 600 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | V | 600 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | ICL3 | L | 437 | - | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | ICL3 | L | 437 | - | G.H5 | D | 346 | G.H5.13 |
Polar | TM6 | S | 438 | 6x19 | G.H5 | D | 346 | G.H5.13 |
Van-der-waals | TM6 | S | 438 | 6x19 | G.H5 | D | 346 | G.H5.13 |
Hydrophobic | C-term | W | 655 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | C-term | W | 655 | - | G.h4s6 | S | 320 | G.h4s6.11 |
Hydrophobic | C-term | L | 603 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | TM6 | I | 445 | 6x26 | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | E | 658 | - | G.H4 | L | 310 | G.H4.12 |
Van-der-waals | C-term | E | 658 | - | G.H4 | L | 310 | G.H4.12 |
Polar | C-term | P | 599 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | P | 599 | - | G.H2 | R | 213 | G.H2.04 |
Hydrophobic | C-term | V | 600 | - | G.H3 | T | 257 | G.H3.11 |
Van-der-waals | C-term | V | 600 | - | G.H3 | T | 257 | G.H3.11 |
Hydrophobic | C-term | I | 569 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | C-term | L | 603 | - | G.H2 | R | 213 | G.H2.04 |
Van-der-waals | C-term | L | 603 | - | G.H2 | R | 213 | G.H2.04 |
Polar | ICL2 | T | 348 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | T | 348 | - | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | TM6 | A | 441 | 6x22 | G.H5 | L | 349 | G.H5.16 |
Polar | C-term | G | 602 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | G | 602 | - | G.H2 | R | 214 | G.H2.05 |
Van-der-waals | C-term | G | 602 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | F | 605 | - | G.H2 | I | 217 | G.H2.08 |
Van-der-waals | C-term | F | 605 | - | G.H2 | I | 217 | G.H2.08 |
Polar | TM6 | S | 438 | 6x19 | G.H5 | Q | 350 | G.H5.17 |
Van-der-waals | TM6 | S | 438 | 6x19 | G.H5 | Q | 350 | G.H5.17 |
Hydrophobic | TM6 | K | 444 | 6x25 | G.H5 | V | 359 | G.H5.26 |
Van-der-waals | TM6 | K | 444 | 6x25 | G.H5 | V | 359 | G.H5.26 |
Hydrophobic | ICL2 | G | 347 | - | G.H5 | I | 348 | G.H5.15 |
Hydrophobic | C-term | L | 656 | - | G.H4 | L | 310 | G.H4.12 |
Polar | ICL2 | L | 346 | - | G.H5 | N | 352 | G.H5.19 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | ICL2 | L | 346 | - | G.H5 | N | 352 | G.H5.19 |
Van-der-waals | C-term | K | 565 | - | G.h2s4 | F | 220 | G.h2s4.01 |
Hydrophobic | C-term | G | 602 | - | G.H2 | R | 213 | G.H2.04 |
Polar | C-term | N | 653 | - | G.H4 | D | 315 | G.H4.17 |
Van-der-waals | C-term | N | 653 | - | G.H4 | D | 315 | G.H4.17 |
Hydrophobic | C-term | I | 661 | - | G.S6 | H | 327 | G.S6.04 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | C-term | I | 637 | - | G.H2 | R | 214 | G.H2.05 |
Hydrophobic | C-term | M | 591 | - | G.H3 | P | 262 | G.H3.16 |
Polar | C-term | K | 565 | - | G.H2 | I | 217 | G.H2.08 |
Polar | C-term | L | 603 | - | G.H3 | Y | 261 | G.H3.15 |
Hydrophobic | C-term | L | 603 | - | G.H3 | Y | 261 | G.H3.15 |
Van-der-waals | C-term | L | 603 | - | G.H3 | Y | 261 | G.H3.15 |
Polar | TM5 | H | 433 | 5x76 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | TM5 | H | 433 | 5x76 | G.H5 | K | 345 | G.H5.12 |
Van-der-waals | TM5 | H | 433 | 5x76 | G.H5 | K | 345 | G.H5.12 |
Hydrophobic | C-term | A | 659 | - | G.H5 | F | 339 | G.H5.06 |
Van-der-waals | C-term | A | 659 | - | G.H5 | F | 339 | G.H5.06 |
Polar | TM6 | K | 440 | 6x21 | G.h4s6 | S | 320 | G.h4s6.11 |
Van-der-waals | TM6 | K | 440 | 6x21 | G.h4s6 | S | 320 | G.h4s6.11 |
Polar | ICL2 | Q | 351 | - | G.hns1 | R | 37 | G.hns1.02 |
Hydrophobic | ICL2 | Q | 351 | - | G.hns1 | R | 37 | G.hns1.02 |
Van-der-waals | ICL2 | Q | 351 | - | G.hns1 | R | 37 | G.hns1.02 |
Polar | C-term | R | 562 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Hydrophobic | C-term | R | 562 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Van-der-waals | C-term | R | 562 | - | G.h3s5 | Q | 265 | G.h3s5.01 |
Hydrophobic | C-term | L | 603 | - | G.H2 | I | 217 | G.H2.08 |
Hydrophobic | ICL3 | L | 436 | - | G.H5 | F | 339 | G.H5.06 |
Polar | C-term | R | 562 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Van-der-waals | C-term | R | 562 | - | G.h3s5 | N | 266 | G.h3s5.02 |
Hydrophobic | C-term | P | 599 | - | G.H3 | E | 250 | G.H3.04 |
Van-der-waals | C-term | P | 599 | - | G.H3 | E | 250 | G.H3.04 |
Polar | TM3 | S | 342 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Hydrophobic | TM3 | S | 342 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Van-der-waals | TM3 | S | 342 | 3x53 | G.H5 | Y | 356 | G.H5.23 |
Aromatic | C-term | K | 565 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | C-term | K | 565 | - | G.H3 | W | 263 | G.H3.17 |
Van-der-waals | C-term | K | 565 | - | G.H3 | W | 263 | G.H3.17 |
Hydrophobic | ICL2 | G | 347 | - | G.H5 | L | 349 | G.H5.16 |
Polar | TM6 | T | 448 | 6x29 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | TM6 | T | 448 | 6x29 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | ICL3 | G | 435 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | ICL3 | L | 437 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL3 | L | 437 | - | G.H5 | L | 349 | G.H5.16 |
Polar | C-term | D | 786 | - | G.HN | N | 22 | G.HN.40 |
Van-der-waals | C-term | D | 786 | - | G.HN | N | 22 | G.HN.40 |
Hydrophobic | C-term | L | 656 | - | G.H4 | V | 314 | G.H4.16 |
Hydrophobic | C-term | L | 603 | - | G.H2 | W | 216 | G.H2.07 |
Polar | C-term | P | 645 | - | G.H3 | R | 256 | G.H3.10 |
Hydrophobic | C-term | P | 599 | - | G.H3 | L | 254 | G.H3.08 |
Van-der-waals | C-term | P | 599 | - | G.H3 | L | 254 | G.H3.08 |
Hydrophobic | ICL3 | L | 436 | - | G.H5 | A | 342 | G.H5.09 |
Hydrophobic | TM3 | F | 343 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Van-der-waals | TM3 | F | 343 | 3x54 | G.H5 | L | 358 | G.H5.25 |
Hydrophobic | C-term | P | 599 | - | G.H3 | A | 253 | G.H3.07 |
Van-der-waals | C-term | P | 599 | - | G.H3 | A | 253 | G.H3.07 |
Polar | ICL2 | L | 346 | - | G.H5 | L | 349 | G.H5.16 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | L | 349 | G.H5.16 |
Van-der-waals | ICL2 | L | 346 | - | G.H5 | L | 349 | G.H5.16 |