GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 71.6
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.6
iPTM Score: 0.6
PAE mean: 16.1
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | C-term | P | 599 | - | G.H3 | L | 249 | G.H3.08 |
Polar | C-term | G | 630 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | G | 630 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | ICL2 | G | 347 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL2 | T | 349 | - | G.h2s4 | T | 219 | G.h2s4.05 |
Polar | C-term | R | 628 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Van-der-waals | C-term | R | 628 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Hydrophobic | TM6 | I | 445 | 6x26 | G.H5 | I | 344 | G.H5.16 |
Polar | TM3 | A | 345 | 3x56 | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | C-term | R | 629 | - | G.H3 | H | 244 | G.H3.03 |
Van-der-waals | C-term | R | 629 | - | G.H3 | H | 244 | G.H3.03 |
Hydrophobic | TM6 | T | 448 | 6x29 | G.H5 | L | 348 | G.H5.20 |
Polar | N-term | P | 10 | - | G.HN | K | 17 | G.HN.41 |
Hydrophobic | N-term | P | 10 | - | G.HN | K | 17 | G.HN.41 |
Van-der-waals | N-term | P | 10 | - | G.HN | K | 17 | G.HN.41 |
Ionic | N-term | R | 8 | - | G.HN | E | 18 | G.HN.42 |
Polar | N-term | R | 8 | - | G.HN | E | 18 | G.HN.42 |
Van-der-waals | N-term | R | 8 | - | G.HN | E | 18 | G.HN.42 |
Polar | C-term | G | 630 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Hydrophobic | C-term | G | 630 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Van-der-waals | C-term | G | 630 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Polar | ICL2 | T | 349 | - | G.S1 | T | 33 | G.S1.01 |
Hydrophobic | ICL2 | T | 348 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | T | 348 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | C-term | P | 599 | - | G.H3 | S | 252 | G.H3.11 |
Van-der-waals | C-term | P | 599 | - | G.H3 | S | 252 | G.H3.11 |
Polar | ICL2 | T | 348 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | T | 348 | - | G.H5 | N | 347 | G.H5.19 |
Polar | TM6 | T | 448 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | TM6 | T | 448 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM6 | T | 448 | 6x29 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | G | 602 | - | G.H2 | K | 209 | G.H2.05 |
Hydrophobic | C-term | F | 605 | - | G.H3 | Y | 258 | G.H3.17 |
Polar | TM3 | W | 339 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | W | 339 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | W | 339 | 3x50 | G.H5 | C | 351 | G.H5.23 |
Aromatic | C-term | F | 605 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | F | 605 | - | G.H3 | H | 256 | G.H3.15 |
Van-der-waals | C-term | F | 605 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | P | 599 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | TM3 | F | 343 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM3 | F | 343 | 3x54 | G.H5 | L | 353 | G.H5.25 |
Hydrophobic | C-term | K | 564 | - | G.H3 | N | 255 | G.H3.14 |
Hydrophobic | C-term | A | 627 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | A | 627 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Aromatic | TM6 | K | 444 | 6x25 | G.H5 | F | 354 | G.H5.26 |
Hydrophobic | TM6 | K | 444 | 6x25 | G.H5 | F | 354 | G.H5.26 |
Van-der-waals | TM6 | K | 444 | 6x25 | G.H5 | F | 354 | G.H5.26 |
Polar | ICL2 | Q | 351 | - | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | ICL2 | Q | 351 | - | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM6 | A | 441 | 6x22 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | A | 441 | 6x22 | G.H5 | D | 341 | G.H5.13 |
Polar | C-term | S | 566 | - | G.H3 | N | 251 | G.H3.10 |
Hydrophobic | ICL3 | L | 436 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Van-der-waals | ICL3 | L | 436 | - | G.s2s3 | K | 192 | G.s2s3.01 |
Polar | ICL2 | T | 349 | - | G.hns1 | D | 30 | G.hns1.01 |
Hydrophobic | C-term | R | 629 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Van-der-waals | C-term | R | 629 | - | G.s4h3 | V | 240 | G.s4h3.14 |
Hydrophobic | TM2 | A | 264 | 2x41 | G.H5 | G | 352 | G.H5.24 |
Hydrophobic | TM6 | A | 441 | 6x22 | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | TM6 | K | 444 | 6x25 | G.H5 | L | 348 | G.H5.20 |
Polar | TM2 | R | 261 | 2x38 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | TM2 | R | 261 | 2x38 | G.H5 | K | 349 | G.H5.21 |
Van-der-waals | TM2 | R | 261 | 2x38 | G.H5 | K | 349 | G.H5.21 |
Hydrophobic | TM3 | F | 343 | 3x54 | G.H5 | C | 351 | G.H5.23 |
Hydrophobic | TM3 | W | 339 | 3x50 | G.H5 | L | 353 | G.H5.25 |
Ionic | TM2 | R | 261 | 2x38 | G.H5 | D | 350 | G.H5.22 |
Polar | TM2 | R | 261 | 2x38 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | R | 261 | 2x38 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | R | 261 | 2x38 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM7 | W | 535 | 7x55 | G.H5 | L | 353 | G.H5.25 |
Van-der-waals | TM7 | W | 535 | 7x55 | G.H5 | L | 353 | G.H5.25 |
Polar | C-term | K | 564 | - | G.H3 | N | 251 | G.H3.10 |
Hydrophobic | C-term | K | 564 | - | G.H3 | N | 251 | G.H3.10 |
Van-der-waals | C-term | K | 564 | - | G.H3 | N | 251 | G.H3.10 |
Hydrophobic | N-term | L | 12 | - | G.HN | K | 17 | G.HN.41 |
Van-der-waals | N-term | L | 12 | - | G.HN | K | 17 | G.HN.41 |
Ionic | C-term | K | 565 | - | G.hgh4 | E | 289 | G.hgh4.04 |
Polar | C-term | K | 565 | - | G.hgh4 | E | 289 | G.hgh4.04 |
Polar | C-term | R | 628 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | C-term | R | 628 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | R | 628 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Polar | C-term | S | 566 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | S | 566 | - | G.H3 | H | 248 | G.H3.07 |
Van-der-waals | C-term | S | 566 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | L | 603 | - | G.H2 | I | 212 | G.H2.08 |
Van-der-waals | C-term | L | 603 | - | G.H2 | I | 212 | G.H2.08 |
Hydrophobic | C-term | A | 570 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | V | 600 | - | G.H2 | W | 211 | G.H2.07 |
Van-der-waals | C-term | V | 600 | - | G.H2 | W | 211 | G.H2.07 |
Hydrophobic | TM3 | S | 342 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Van-der-waals | TM3 | S | 342 | 3x53 | G.H5 | C | 351 | G.H5.23 |
Polar | C-term | R | 629 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | C-term | R | 629 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | R | 629 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | TM6 | I | 445 | 6x26 | G.H5 | L | 348 | G.H5.20 |
Polar | TM2 | P | 263 | 2x40 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | TM2 | P | 263 | 2x40 | G.H5 | D | 350 | G.H5.22 |
Van-der-waals | TM2 | P | 263 | 2x40 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | N-term | R | 8 | - | G.HN | K | 21 | G.HN.45 |
Polar | C-term | K | 567 | - | G.H3 | H | 248 | G.H3.07 |
Hydrophobic | C-term | K | 567 | - | G.H3 | H | 248 | G.H3.07 |
Polar | N-term | G | 9 | - | G.HN | K | 17 | G.HN.41 |
Van-der-waals | N-term | G | 9 | - | G.HN | K | 17 | G.HN.41 |
Hydrophobic | C-term | F | 605 | - | G.H3 | K | 257 | G.H3.16 |
Van-der-waals | C-term | F | 605 | - | G.H3 | K | 257 | G.H3.16 |
Hydrophobic | ICL2 | T | 348 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | T | 348 | - | G.H5 | I | 343 | G.H5.15 |
Polar | ICL2 | L | 346 | - | G.H5 | N | 347 | G.H5.19 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | N | 347 | G.H5.19 |
Van-der-waals | ICL2 | L | 346 | - | G.H5 | N | 347 | G.H5.19 |
Polar | ICL2 | L | 346 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | I | 344 | G.H5.16 |
Hydrophobic | ICL2 | T | 349 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | ICL3 | L | 436 | - | G.H5 | F | 336 | G.H5.08 |
Van-der-waals | ICL3 | L | 436 | - | G.H5 | F | 336 | G.H5.08 |
Polar | C-term | P | 599 | - | G.H2 | R | 208 | G.H2.04 |
Hydrophobic | C-term | P | 599 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | P | 599 | - | G.H2 | R | 208 | G.H2.04 |
Polar | C-term | R | 629 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Hydrophobic | C-term | R | 629 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Van-der-waals | C-term | R | 629 | - | G.s4h3 | D | 237 | G.s4h3.11 |
Hydrophobic | ICL3 | L | 437 | - | G.H5 | I | 344 | G.H5.16 |
Polar | ICL2 | Y | 350 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | Y | 350 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | Y | 350 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | H8 | L | 543 | 8x52 | G.h4s6 | E | 315 | G.h4s6.09 |
Van-der-waals | H8 | L | 543 | 8x52 | G.h4s6 | E | 315 | G.h4s6.09 |
Ionic | TM2 | R | 261 | 2x38 | G.H5 | E | 346 | G.H5.18 |
Polar | TM2 | R | 261 | 2x38 | G.H5 | E | 346 | G.H5.18 |
Hydrophobic | TM2 | R | 261 | 2x38 | G.H5 | E | 346 | G.H5.18 |
Van-der-waals | TM2 | R | 261 | 2x38 | G.H5 | E | 346 | G.H5.18 |
Hydrophobic | C-term | V | 600 | - | G.H2 | R | 208 | G.H2.04 |
Van-der-waals | C-term | V | 600 | - | G.H2 | R | 208 | G.H2.04 |
Ionic | C-term | R | 629 | - | G.H3 | E | 245 | G.H3.04 |
Ionic | TM6 | K | 440 | 6x21 | G.h4s6 | E | 318 | G.h4s6.12 |
Polar | TM6 | K | 440 | 6x21 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | TM6 | K | 440 | 6x21 | G.h4s6 | E | 318 | G.h4s6.12 |
Van-der-waals | TM6 | K | 440 | 6x21 | G.h4s6 | E | 318 | G.h4s6.12 |
Hydrophobic | C-term | A | 601 | - | G.H2 | K | 209 | G.H2.05 |
Van-der-waals | C-term | A | 601 | - | G.H2 | K | 209 | G.H2.05 |
Polar | TM2 | A | 264 | 2x41 | G.H5 | D | 350 | G.H5.22 |
Hydrophobic | ICL2 | Y | 350 | - | G.HN | A | 27 | G.HN.51 |
Hydrophobic | ICL2 | T | 348 | - | G.hns1 | R | 32 | G.hns1.03 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | L | 348 | G.H5.20 |
Hydrophobic | C-term | L | 603 | - | G.h2s4 | F | 215 | G.h2s4.01 |
Polar | TM6 | S | 438 | 6x19 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | TM6 | S | 438 | 6x19 | G.H5 | D | 341 | G.H5.13 |
Van-der-waals | TM6 | S | 438 | 6x19 | G.H5 | D | 341 | G.H5.13 |
Hydrophobic | C-term | L | 603 | - | G.H3 | H | 256 | G.H3.15 |
Hydrophobic | C-term | V | 600 | - | G.H3 | L | 249 | G.H3.08 |
Van-der-waals | C-term | V | 600 | - | G.H3 | L | 249 | G.H3.08 |
Hydrophobic | ICL2 | L | 346 | - | G.H5 | I | 343 | G.H5.15 |
Van-der-waals | ICL2 | L | 346 | - | G.H5 | I | 343 | G.H5.15 |
Hydrophobic | N-term | E | 11 | - | G.HN | K | 17 | G.HN.41 |
Van-der-waals | N-term | E | 11 | - | G.HN | K | 17 | G.HN.41 |
Polar | ICL2 | T | 349 | - | G.hns1 | A | 31 | G.hns1.02 |
Hydrophobic | ICL2 | T | 349 | - | G.hns1 | A | 31 | G.hns1.02 |
Van-der-waals | ICL2 | T | 349 | - | G.hns1 | A | 31 | G.hns1.02 |
Ionic | C-term | R | 576 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Polar | C-term | R | 576 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Hydrophobic | C-term | R | 576 | - | G.s4h3 | E | 239 | G.s4h3.13 |
Van-der-waals | C-term | R | 576 | - | G.s4h3 | E | 239 | G.s4h3.13 |