Gz -
SST1 receptor complex model
GPCR CLASS (FAMILY)
SPECIES
G PROTEIN FAMILY
DATE
3D VIEW
Tertiary structure confidence
(pLDDT score) avg.: 77.7
Confident (90-70)
Low (70-50)
Very low (<50)
Disordered
PTM Score: 0.7
iPTM Score: 0.7
PAE mean: 13.5
GPCR - G protein interface interactions
The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle
(Gα residues)
and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid,
hydrophobic - dashed,
ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.
GPCR-G protein backbone (bb) or sidechain (sc):
Structures
0 structures selected.
Sequence Color
Interaction frequency filter (%)
Gα,
GPCR
Interaction cut-off: strict (stick), loose (line)
Interaction type |
GPCR Segment |
AA |
Number |
Generic number |
Gα segment |
AA |
Number |
Generic number |
---|---|---|---|---|---|---|---|---|
Polar | ICL2 | P | 162 | 34x50 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | ICL2 | I | 163 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Van-der-waals | ICL2 | I | 163 | 34x51 | G.S3 | L | 195 | G.S3.01 |
Hydrophobic | TM6 | V | 273 | 6x37 | G.H5 | L | 354 | G.H5.25 |
Polar | C-term | S | 360 | - | G.h2s4 | V | 219 | G.h2s4.04 |
Van-der-waals | C-term | S | 360 | - | G.h2s4 | V | 219 | G.h2s4.04 |
Polar | C-term | C | 384 | - | G.HG | I | 286 | G.HG.17 |
Polar | TM3 | R | 155 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM3 | R | 155 | 3x50 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | C-term | F | 368 | - | G.H2 | I | 213 | G.H2.08 |
Van-der-waals | C-term | F | 368 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | T | 383 | - | G.hgh4 | P | 289 | G.hgh4.03 |
Hydrophobic | C-term | S | 386 | - | G.s4h3 | Q | 240 | G.s4h3.13 |
Van-der-waals | C-term | S | 386 | - | G.s4h3 | Q | 240 | G.s4h3.13 |
Van-der-waals | C-term | L | 358 | - | G.H5 | N | 347 | G.H5.18 |
Polar | C-term | S | 360 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | S | 360 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | C-term | G | 382 | - | G.hgh4 | E | 290 | G.hgh4.04 |
Aromatic | C-term | Y | 363 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | Y | 363 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | Y | 363 | - | G.H3 | W | 259 | G.H3.17 |
Ionic | TM6 | R | 262 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | TM6 | R | 262 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | TM6 | R | 262 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | R | 262 | 6x26 | G.h4s6 | E | 319 | G.h4s6.12 |
Polar | C-term | Y | 354 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | C-term | Y | 354 | - | G.hns1 | R | 31 | G.hns1.02 |
Van-der-waals | C-term | Y | 354 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | C-term | C | 384 | - | G.H3 | A | 245 | G.H3.03 |
Hydrophobic | ICL2 | P | 162 | 34x50 | G.H5 | T | 341 | G.H5.12 |
Polar | C-term | C | 384 | - | G.s4h3 | S | 242 | G.s4h3.15 |
Hydrophobic | C-term | C | 384 | - | G.s4h3 | S | 242 | G.s4h3.15 |
Van-der-waals | C-term | C | 384 | - | G.s4h3 | S | 242 | G.s4h3.15 |
Polar | H8 | N | 329 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Van-der-waals | H8 | N | 329 | 8x49 | G.H5 | K | 350 | G.H5.21 |
Polar | C-term | Y | 353 | - | G.H5 | Y | 351 | G.H5.22 |
Aromatic | C-term | Y | 353 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | Y | 353 | - | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | C-term | Y | 353 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM2 | T | 93 | 2x39 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | C-term | L | 358 | - | G.S1 | I | 34 | G.S1.02 |
Van-der-waals | C-term | L | 358 | - | G.S1 | I | 34 | G.S1.02 |
Hydrophobic | TM3 | A | 158 | 3x53 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | TM6 | M | 272 | 6x36 | G.H5 | G | 353 | G.H5.24 |
Van-der-waals | TM6 | M | 272 | 6x36 | G.H5 | G | 353 | G.H5.24 |
Aromatic | C-term | F | 368 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | C-term | F | 368 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Van-der-waals | C-term | F | 368 | - | G.h2s4 | F | 216 | G.h2s4.01 |
Hydrophobic | H8 | D | 328 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | H8 | D | 328 | 8x48 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | ICL2 | I | 163 | 34x51 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | C-term | N | 372 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | TM6 | M | 272 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | M | 272 | 6x36 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | K | 268 | 6x32 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | C-term | L | 358 | - | G.H5 | V | 343 | G.H5.14 |
Polar | C-term | Y | 353 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | TM6 | I | 269 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM6 | I | 269 | 6x33 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM3 | V | 159 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM3 | V | 159 | 3x54 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | E | 349 | - | G.h3s5 | N | 262 | G.h3s5.02 |
Polar | C-term | Y | 354 | - | G.HN | S | 27 | G.HN.51 |
Hydrophobic | C-term | F | 368 | - | G.H3 | N | 257 | G.H3.15 |
Van-der-waals | C-term | F | 368 | - | G.H3 | N | 257 | G.H3.15 |
Polar | C-term | A | 355 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | A | 355 | - | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | C-term | A | 355 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | S | 364 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | S | 364 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | F | 379 | - | G.h4s6 | R | 313 | G.h4s6.03 |
Hydrophobic | ICL3 | A | 257 | - | G.S6 | H | 323 | G.S6.04 |
Ionic | C-term | K | 359 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Polar | C-term | K | 359 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Hydrophobic | C-term | C | 384 | - | G.hgh4 | P | 289 | G.hgh4.03 |
Hydrophobic | ICL3 | A | 257 | - | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | ICL3 | A | 257 | - | G.S6 | Y | 321 | G.S6.02 |
Polar | TM6 | W | 259 | 6x23 | G.S6 | I | 320 | G.S6.01 |
Hydrophobic | TM6 | W | 259 | 6x23 | G.S6 | I | 320 | G.S6.01 |
Van-der-waals | TM6 | W | 259 | 6x23 | G.S6 | I | 320 | G.S6.01 |
Ionic | TM6 | R | 264 | 6x28 | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | TM6 | R | 264 | 6x28 | G.h4s6 | E | 316 | G.h4s6.09 |
Van-der-waals | TM6 | R | 264 | 6x28 | G.h4s6 | E | 316 | G.h4s6.09 |
Polar | C-term | L | 358 | - | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | C-term | L | 358 | - | G.h2s4 | T | 220 | G.h2s4.05 |
Van-der-waals | C-term | L | 358 | - | G.h2s4 | T | 220 | G.h2s4.05 |
Hydrophobic | TM3 | V | 159 | 3x54 | G.H5 | I | 352 | G.H5.23 |
Hydrophobic | H8 | S | 327 | 8x47 | G.H5 | G | 353 | G.H5.24 |
Polar | C-term | T | 356 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | T | 356 | - | G.H5 | Y | 351 | G.H5.22 |
Van-der-waals | C-term | T | 356 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM3 | V | 159 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Van-der-waals | TM3 | V | 159 | 3x54 | G.H5 | I | 345 | G.H5.16 |
Polar | C-term | D | 352 | - | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | TM6 | I | 269 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Van-der-waals | TM6 | I | 269 | 6x33 | G.H5 | L | 349 | G.H5.20 |
Polar | C-term | L | 373 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | C-term | L | 373 | - | G.H3 | S | 253 | G.H3.11 |
Van-der-waals | C-term | L | 373 | - | G.H3 | S | 253 | G.H3.11 |
Hydrophobic | TM3 | R | 155 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Van-der-waals | TM3 | R | 155 | 3x50 | G.H5 | L | 354 | G.H5.25 |
Hydrophobic | TM6 | W | 259 | 6x23 | G.h4s6 | E | 319 | G.h4s6.12 |
Van-der-waals | TM6 | W | 259 | 6x23 | G.h4s6 | E | 319 | G.h4s6.12 |
Hydrophobic | ICL3 | A | 257 | - | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | C-term | A | 362 | - | G.h2s4 | E | 217 | G.h2s4.02 |
Polar | TM6 | S | 265 | 6x29 | G.H5 | Q | 346 | G.H5.17 |
Ionic | ICL2 | K | 164 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | ICL2 | K | 164 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Hydrophobic | ICL2 | K | 164 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Van-der-waals | ICL2 | K | 164 | 34x52 | G.s2s3 | E | 194 | G.s2s3.02 |
Polar | C-term | T | 356 | - | G.hns1 | R | 31 | G.hns1.02 |
Polar | C-term | S | 360 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Hydrophobic | C-term | S | 360 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Van-der-waals | C-term | S | 360 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Ionic | TM6 | R | 262 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Polar | TM6 | R | 262 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | TM6 | R | 262 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM6 | R | 262 | 6x26 | G.H5 | D | 342 | G.H5.13 |
Polar | H8 | N | 329 | 8x49 | G.H5 | Y | 351 | G.H5.22 |
Hydrophobic | C-term | L | 373 | - | G.H3 | L | 250 | G.H3.08 |
Hydrophobic | TM6 | W | 259 | 6x23 | G.S6 | Y | 321 | G.S6.02 |
Hydrophobic | TM5 | V | 253 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Van-der-waals | TM5 | V | 253 | 5x68 | G.H5 | D | 342 | G.H5.13 |
Hydrophobic | C-term | F | 379 | - | G.H3 | D | 252 | G.H3.10 |
Van-der-waals | C-term | F | 379 | - | G.H3 | D | 252 | G.H3.10 |
Polar | TM3 | A | 158 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM3 | A | 158 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Van-der-waals | TM3 | A | 158 | 3x53 | G.H5 | N | 348 | G.H5.19 |
Hydrophobic | TM5 | K | 249 | 5x64 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | V | 365 | - | G.H2 | I | 213 | G.H2.08 |
Hydrophobic | C-term | A | 357 | - | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | P | 162 | 34x50 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | K | 359 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Van-der-waals | C-term | K | 359 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Hydrophobic | ICL2 | I | 163 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Van-der-waals | ICL2 | I | 163 | 34x51 | G.H5 | F | 337 | G.H5.08 |
Hydrophobic | TM6 | R | 262 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Van-der-waals | TM6 | R | 262 | 6x26 | G.H5 | Q | 346 | G.H5.17 |
Hydrophobic | ICL2 | R | 169 | 34x57 | G.H5 | I | 352 | G.H5.23 |
Van-der-waals | ICL2 | R | 169 | 34x57 | G.H5 | I | 352 | G.H5.23 |
Polar | TM4 | R | 170 | 4x38 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | TM4 | R | 170 | 4x38 | G.HN | Q | 28 | G.HN.52 |
Van-der-waals | TM4 | R | 170 | 4x38 | G.HN | Q | 28 | G.HN.52 |
Hydrophobic | TM5 | M | 250 | 5x65 | G.H5 | L | 349 | G.H5.20 |
Hydrophobic | TM6 | I | 269 | 6x33 | G.H5 | C | 355 | G.H5.26 |
Van-der-waals | TM6 | I | 269 | 6x33 | G.H5 | C | 355 | G.H5.26 |
Hydrophobic | C-term | V | 365 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | F | 379 | - | G.h4s6 | L | 311 | G.h4s6.01 |
Polar | C-term | L | 358 | - | G.h2s4 | V | 219 | G.h2s4.04 |
Van-der-waals | C-term | L | 358 | - | G.h2s4 | V | 219 | G.h2s4.04 |
Polar | C-term | C | 384 | - | G.hgh4 | C | 287 | G.hgh4.01 |
Hydrophobic | C-term | C | 384 | - | G.hgh4 | C | 287 | G.hgh4.01 |
Van-der-waals | C-term | C | 384 | - | G.hgh4 | C | 287 | G.hgh4.01 |
Hydrophobic | C-term | L | 373 | - | G.H3 | I | 254 | G.H3.12 |
Aromatic | C-term | F | 368 | - | G.H3 | W | 259 | G.H3.17 |
Hydrophobic | C-term | F | 368 | - | G.H3 | W | 259 | G.H3.17 |
Van-der-waals | C-term | F | 368 | - | G.H3 | W | 259 | G.H3.17 |
Polar | ICL2 | A | 166 | 34x54 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | ICL2 | A | 166 | 34x54 | G.hns1 | R | 31 | G.hns1.02 |
Hydrophobic | C-term | L | 358 | - | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | ICL2 | P | 162 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Van-der-waals | ICL2 | P | 162 | 34x50 | G.H5 | I | 344 | G.H5.15 |
Hydrophobic | C-term | I | 388 | - | G.s4h3 | Q | 240 | G.s4h3.13 |
Hydrophobic | TM5 | V | 253 | 5x68 | G.H5 | I | 345 | G.H5.16 |
Hydrophobic | C-term | L | 358 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Van-der-waals | C-term | L | 358 | - | G.h2s4 | G | 218 | G.h2s4.03 |
Hydrophobic | ICL3 | K | 256 | - | G.H5 | D | 338 | G.H5.09 |
Polar | TM6 | R | 262 | 6x26 | G.S6 | Y | 321 | G.S6.02 |
Van-der-waals | TM6 | R | 262 | 6x26 | G.S6 | Y | 321 | G.S6.02 |